Volume 31 Issue 3
Jun.  2007
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Progress of interleukin-24 study

  • Interleukin-24 (11-24) is a member of interleukin-10 family. Besides its character as a cytokine, IL-24 could induce apoptosis of different kinds of tumor cells without any harmful effects to normal cells. IL-24 could both promote bystander anti-tumor effect,inhibit tumor growth and angiogenesis in animal models. It also has effects of radiosensitization and immunoregulation.
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  • [1] Jiang H,Lin JJ,Su ZZ,et al.Subtraction hybridization identifies a novel melanoma differentiation associated gene,mda-7,modulated during human melanoma differentiation,growth and progression.Oncogene,1995,11(12):2477-2486.
    [2] Caudell EG,Mumm JB,Poindexter N,et al.The protein product of the tumor suppressor gene,melanoma differentiation-associated gene 7,exhibits immunostimulatory activity and is designated IL-24.J Immunol,2002,168(12):6041-6046.
    [3] Huang EY,Madireddi MT,Gopalkrishnan RV,et al.Genomic structure,chromosomal localization and expression profile of a novelmelanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.Oncogene,2001,20 (48):7051-7063.
    [4] Fisher PB,Gopalkrishnan RV,Chada S,et al.Mda-7/IL-24,a novel cancer selective apoptosis inducing cytokine gene:from the laboratory into the clinic.Cancer Biol Ther,2003,2(4):23-37.
    [5] Lebedeva IV,Su ZZ,Sarkar D,et al.Melanoma differentiation associated gene-7,mda-7/Interleukin-24,induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.Cancer Res,2003,63(23):81388144.
    [6] Pataer A,Vorburger SA,Barber GN,et al.Adenoviral transfer of the melanoma difTerentiation-associated gene-7 induces apoptasis of lung cancer cells via up-regulation the double-stranded RNA-dependent protein kinase (PKR).Cancer Res,2002,62(8):2239-2243.
    [7] Sarkar D,Su ZZ,Lebedeva IV,et al.Mda-7/IL-24 mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38MAPK.Proc Natl Acad Sci USA,2002,99 (15):10054-10059.
    [8] Sauane M,Lebedeva IV,Su ZZ,et al.Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.Cancer Res,2004,64(9):2988-2993.
    [9] Su Z,Lebedeva IV,Gopalkrishnan RV,et al.A combinatorialapp roach for selectively inducing programmed cell death in human pancreatic cancer cells.Proc Natl Acad Sci USA,2001,98 (18):10332-10337.
    [10] Ramesh R,Mhashilkar AM,Tanaka F,et al.Melanoma differentiation-associated gene 7/Interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.Cancer Res,2003,63(16):5105-5113.
    [11] Mhashilkar AM,Stewart AL,Sieger K,et al.MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.Mol Ther,2003,8:207-219.
    [12] Ramesh R,Ito I,Gopaian B,et al.Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells.Mol Ther,2004,9(4):510-518.
    [13] Su Z,Emdad L,Sauane M,et al.Unique aspects of mda-7/IL-24 antitumor bystander activity:establishing a role for secretion of MDA-7/IL-24 protein by normal cells.Oncogene,2005,24(51):7552-7566.
    [14] Mhashilkar AM,Schrock HD,Hindi M,et al.Melanoma differentiation associated gene-7 (mda-7):a novel anti-tumor genefor cancer gene therapy.Mol Med,2001,7(4):271-282.
    [15] Nishikawa T,Ramesh R,Munshi A,et al.Adenovirus-mediated mda-7(IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation.Mol Ther,2004,9(6):818-828.
    [16] Yacoub A,Mitchell C,Lebedeva IV,et al.Mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.Cancer Biol Ther,2003,2(4):347-353.
    [17] Dent P,Yacoub A,Grant S,et al.MDA-7/IL-24 regulates proliferation,invasion and tumor cell radiosensitivity:a new cancer therapy?.J Cell Biochem,2005,95(4):712-719.
    [18] Nishikawa T,Munshi A,Story MD,et al.Adenoviral-mediated mda-7 expression suppresses DNA repair capacity and radiosensitizes non-small-cell lung cancer cells.Oncogene,23(42):7125-7131.
    [19] Emdad L,Sarkar D,Lebedeva IV,et al.Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.J Cell Physiol,2006,208(2):298-306.
    [20] Su ZZ,Lebedeva IV,Sarkar D,et al.Ionizing radiation enhances therapeutic activity of mda-7/IL-24:overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing th eantiapoptotic proteins bcl-xL or bcl-2.Oncogene,2006,25 (16):2339-2348.
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Progress of interleukin-24 study

    Corresponding author: JIN Shun-zi, shunzij@yahoo.com.cn
  • Key Laboratory of Radiob iology, Ministry of Health, School of Public Health, Jilin University, Changchun 130021, China

Abstract: Interleukin-24 (11-24) is a member of interleukin-10 family. Besides its character as a cytokine, IL-24 could induce apoptosis of different kinds of tumor cells without any harmful effects to normal cells. IL-24 could both promote bystander anti-tumor effect,inhibit tumor growth and angiogenesis in animal models. It also has effects of radiosensitization and immunoregulation.

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