Volume 26 Issue 4
Aug.  2002
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Citation:

The application of 99Tcm-MIBI imaging to detect multidrug resistance

  • Received Date: 2002-04-24
  • Multidrug resistance is the main cause of chemotherapy failure,To detect multidrug resistance is helpful to develop chemotherapy regimens and more effective treatment of patients with tumors. 99Tcm-sestamibi is a transport sub-strate of mdr1-encoded P-glycoprotein and MRP.The lower 99Tcm-sestamibi accumulation indicates the higher expression of P-glycoprotein in tumor cells.It is also related to the expression of MRP.As a result,response to chemotherapy can be estimated before starting treatment by means of 99Tcm-sestamibi imaging and more effective protocol can be chosen.
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  • [1] Shung-Shung S, Tih-Fang H, Shih-chuan T, et al. Expression of mediated P-glycoprotein multidrug resistance related to Tc-99m MIBI scintimammography results[J]. Cancer Lett, 2000, 153(1-2):95-100.
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    [5] Andrews DW, Dss R, Kim S, et al. Technetium-MIBI as a glioma imaging agent for the assessment of multidrug resistance[J]. Neurosurgery, 1997, 40(6):1323-1332.
    [6] Kapucu LÖ, Akyüz C, Varal G, et al. Evaluation of therapy response in children with untreated malignant lymphomas using technetium-99m-sestamibi[J]. J Nucl Med, 1997, 38(2):243-247.
    [7] Gruber A, Areström I, Xu D, et al. Multidrug resistance phenotype in leukaemia cells from patients with acute myelocytie leukaemia can be detected with 99Tcm-MIBI[J]. Br J Cancer, 1998, 77(11):1732-1736.
    [8] Kostakoglu L, Guc D, Canpinar H, et al. P-glycoprotein expression by technetium-99m-MIBI scintigraphy in hematologic malignancy[J]. J Nucl Med, 1998, 39(7):1191-1197.
    [9] Leitha T, Glaser C, Lang S. Is early sestamibi imaging in head and neck cancer affected by MDR status, P53 expression, or cell proliferation?[J]. Nucl Med Biol, 1998, 25(6):539-541.
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    [13] Hendrikse NH, Franssen EJF, Van-der-Graaf WTA, et al.99Tcm-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein[J]. Br J Cancer, 1998, 77(3):353-358.
    [14] Moretti JL, Duran-Cordobes M, Starzec A, et al. Involvement of glutathione in loss of technetium-99m-MIBI accumulation related to membrane MDR protein expression in tumor cells[J]. J Nucl Med, 1998, 39(7):1214-1218.
    [15] Chia-Hung K, Shih-Chuan T, Tse-Jia L, et al. P-glycoprotein and multidrug resistance-related protein expressions in relation to technetium-99m methoxyisobutylisonitrile scintimammography findings[J]. Cancer Res, 2001, 61(4):1412-1414.
    [16] Chia-Hung K, Shih-Chuan T, Thi-Joung W, et al. Technetium-99m-sestamethoxyisobutylisonitrile scan as a predictor of chemotherapy response in malignant lymphomas compared with P-glycoprotein expression multidrug resistance-related protein expression and other prognosis factors[J]. Br J Haematol, 2001, 113(2):369-374.
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The application of 99Tcm-MIBI imaging to detect multidrug resistance

  • Medical College of Southeast University, Jiangsu Nanjing 210009, China

Abstract: Multidrug resistance is the main cause of chemotherapy failure,To detect multidrug resistance is helpful to develop chemotherapy regimens and more effective treatment of patients with tumors. 99Tcm-sestamibi is a transport sub-strate of mdr1-encoded P-glycoprotein and MRP.The lower 99Tcm-sestamibi accumulation indicates the higher expression of P-glycoprotein in tumor cells.It is also related to the expression of MRP.As a result,response to chemotherapy can be estimated before starting treatment by means of 99Tcm-sestamibi imaging and more effective protocol can be chosen.

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