Volume 25 Issue 1
Feb.  2001
Article Contents

Citation:

Nuclear medicine methods in the field of studying the mechanisms of delayed phase of myocardial preconditioning

  • Received Date: 2000-09-04
  • Ischemic preconditioning is the intrinsic and most potently myocardial protection we know now. To illu-minate its mechanism is the foundation of rational theraputic application. Nowadays there are some theories about delayed phase of preconditioning such as nitric oxide hypothesis, free radical mechanisms, protective protein syn-thesis and opening of AT P-sensitive potassium channels. By incorporation 3H-leucine, using liquid scintillation counter, we now know there was protective protein synthesis during preconditioning. SPECT could study the char-acteristics of preconditioned myocardium in vivo, and PET might further show the metabolism, energy consumption and its relationship to myocardium dysfunction.
  • 加载中
  • [1] Meldrum DR.Mechanisms of cardialc precondition-ing:ten years after the discovery of ischemic precondi-tioning[J].J Surg Res,1997,73(1):1-13.
    [2] Nagao K,Satou K,Arima K,et al.Relationship be-tween preinfarction angina and time interval to reper-fusion with thrombolytic therapy in acute myocardial infartion[J].Jpn Circ J,1997,61(10):843-849.
    [3] Tomoda H,Aoki N.Comparision of protective effects of preinfarction angina pectoris in aucte myocardial in-farction treated by thrombolysis versus by primary coronary angioplasty with stenting[J].Am J Cardiol,1999,84(6):621-625.
    [4] Ishihara M,Sato H,Tateishi H,et al.Implications of prodromal angina pectoris in anterior wall acute my-ocardial infarction:acute angiographic findings and long-term prognosis[J].J Am Coll Cardiol,1997,30(4).970-975.
    [5] Dana A,Baxter GF,Walker JM,et al.Prolonging the delayed phase of myocardial protection:repetitive adenosine A1 recepter activation maintains rabbit my-ocardium in a preconditioned state[J].J Am Coll Car-diol,1998,31(5):1142-1149.
    [6] Meldrum DR,Cleveland JC Jr,Rowland RT,et al.Early and delayed preconditioning:differential mecha-nisms and additive protection[J].Am J Physiol,1997,273(2 Pt 2):H725-H733.
    [7] Bolli R,Bhatti ZA,Tang XL,et al.Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of ni-tric oxide[J].Circ Res,1997,81(1):42-52.
    [8] Ping P,Takano H,Zhang J,et al.Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits:a signaling mechanism for both nitric oxide-induced and ischemia-induced precon-ditioning[J].Circ Res,1999,84(5):587-604.
    [9] Xuan YT,Tang XL,Banerjee S,et al.Nuclear factor-kappa B plays an essential role in the late phase of ischemic preconditioning in conscious rabbits[J].Circ Res,1999,84(9):1095-1109.
    [10] Jones W K,Flaherty M P,Tang XL,et al.Ischemic preconditioning increases iNO S transcript levels in conscious rabbits via a nitric oxide-dependent mecha-nism[J].J Mol Cell Cardiol,1999,31(8):1469-1481.
    [11] Imagawa J,Yellon DM,Baxter GF.Pharmacological evidence that inducible nitric oxide synthase is a media-tor of delayed preconditioning[J].Br J Pharmacol,1999,126(3):701-708.
    [12] Rizvi A,Tang XL,Qiu Y,et al.Increased protein synthesis is necessary for the development of late pre-conditioning against myocardial stunning[J].Am J Physiol,1999,277(3 Pt 2):H874-H884.
    [13] Su CY,Chong KY,Owen OE,et al.Constitutive and inducible hsp 70s are involved in oxidaive resistance e-voked by heat shock or ethanol[J].J Mol Cell Cardi-ol,1998,30(3):587-598.
    [14] Yamashita N,Hoshida S,Taniguchi N,et al.A "sec-ond window of protection" occurs 24h after ischemic preconditioning in the rat heart[J].J Mol Cell Cardi-ol,1998,30(6):1181-1189.
    [15] Dana A,Jonassen AK,Yamashita N,et al.Adeno-sine A(1) receptor activation indues delayed precondi-tioning in rats mediated by manganese superoxide dis-mutase[J].Circulation,2000,101(24):2841-2848.
    [16] Baghelai K,Graham LJ,Wechsler AS,et al.Delayed myocardial preconditioning by alphal-adrenoceptors in-volves inhibition of apoptosis[J].J Thorac Cardiovasc Surg,1999,117(5):980-986.
    [17] Bernardo NL,D'Angelo M,Okubos,et al.Delayedischemic preconditioning is mediated by opening ofATP-sensitive potassium channels in the rabbit heart[J].Am J Physiol,1999,276(4 Pt 2):H1323-H1330.
    [18] Bernardo N L,Okubo S,Maaieh MM,et al.Delayed preconditioning with adenosine is mediated by opening of AT P-sensitive K (+) channels in rabbit heart[J].Am J Physiol,1999,277(1 Pt 2):H128-H135.
    [19] KhawBA.The current role of infarct avid imaging[J].Semin Nucl Med,1999,(3):259-270.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1007) PDF downloads(3) Cited by()

Related
Proportional views

Nuclear medicine methods in the field of studying the mechanisms of delayed phase of myocardial preconditioning

  • Department of Nuclear Medicine, No.2, Affiliated Hospital, China Medical University, Liaoning, Shengyang 110001, China

Abstract: Ischemic preconditioning is the intrinsic and most potently myocardial protection we know now. To illu-minate its mechanism is the foundation of rational theraputic application. Nowadays there are some theories about delayed phase of preconditioning such as nitric oxide hypothesis, free radical mechanisms, protective protein syn-thesis and opening of AT P-sensitive potassium channels. By incorporation 3H-leucine, using liquid scintillation counter, we now know there was protective protein synthesis during preconditioning. SPECT could study the char-acteristics of preconditioned myocardium in vivo, and PET might further show the metabolism, energy consumption and its relationship to myocardium dysfunction.

    HTML

Reference (19)

Catalog

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return