Volume 29 Issue 2
Apr.  2005
Article Contents

Citation:

Potential therapeutic uses for rhTSH in thyroid diseases

  • Received Date: 2005-02-01
  • Currently, recombinant human TSH (rhTSH) is only approved in USA and Europe for diag-nostic monitoring of differentiated thyroid cancer patients. However, there are many other potential uses for rhTSH, including facilitation of treatment of patients with thyroid cancer and nodular goiter. The therapeutic role of rhTSH in patients with differentiated thyroid cancer and nodular goiter will be discussed in this review.
  • 加载中
  • [1] Robbins RJ. Pharmacology of bovine and human thyrotropin:an historical perspective[J]. Thyroid, 1999, 9(3):451-453.
    [2] Robbins RJ, Tuttle RM, Sonenberg M, et al. Radio-iodine ablation of thyroid remnants after preparation with recombinant human thyrotropin[J]. Thyroid, 2001, 11(6):865-869.
    [3] Robbins RJ, Larson SM, Sinha N, et al. A retrospective review of the effectiveness of recombinant human TSH as a preparation for radioiodine thyroid remnant ablation[J]. J Nucl Med, 2002, 43(7):1482-1488.
    [4] Pacini F, Molinaro E, Castagna MG, et al. Ablation of thyroid residues with 30mCi of 131I:a comparison in thyroid cancer patients prepared with recombinant human TSH or thyroid hormone withdrawal[J]. J Clin Endocrinol Metab, 2002, 87(6):4063-4068.
    [5] Barbaro D, Boni G, Meucci G, et al. Radio-iodine treatment with 30mCi after recombinant human thyrotropin stimulation in thyroid cancer:Effectiveness for postsurgical remnant ablation and possible role of iodine content in L-thyroxine in the outcome of ablation[J]. J Clin Endocrinol Metab, 2003, 89(6):4110-4115.
    [6] Luster M, Lassmann M, Haenscheid H, et al. Use of recombinant human thyrotropin before radio-iodine therapy in patients with advanced differentiated thyroid carcinoma[J]. J Clin Endocrinol Metab, 2000, 85(5):3640-3645.
    [7] Lippi F, Capezzone M, Angelini F, et al. Radio-iodine treatment of metastatic differentiated thyroid cancer in patients on L-thyroxine,using recombinant human TSH[J]. Eur J Endocrinol, 2001, 144(1):5-11.
    [8] Berg G, Lindstedt G, Suurkula M, et al. Radio-iodine ablation and therapy in differentiated thyroid cancer under stimulation with recombinant human thyroid-stimulating hormone[J]. J Endocrinol Inv, 2002, 25(1):44-52.
    [9] de Keizer B, Hoekstra A, Konijnenberg MW, et al. Bone marrow dosimetry and safety of high 131I activities given after recombinant human thyroid-stimulating hormone to treat metastatic differentiated thyroid cancer[J]. J Nucl Med, 2004, 45(9):1549-1554.
    [10] Santini F, Bottici V, Elisei R, et al. Cytotoxic effects of carboplatinum and epirubicin in the setting of an elevated serum thyrotropin for advanced poorly differentiated thyroid cancer[J]. J Clin Endocrinol Metab, 2002, 87(6):4160-4165.
    [11] Haugen BR. Management of the patient with progressive radioiodine non-responsive disease[J]. Semin Sur Oncol, 1999, 16(1):34-41.
    [12] Huysmans DA, Nieuwlaat WA, Erdtsieck R J, et al. Administration of a single low dose of recombinant human thyrotrepin significantly enhances thyroid radio-iodide uptake in nontoxic nodular goiter[J].J Clin Endocrinol Metab, 2000, 85(5):3592-3596.
    [13] Nieuwlaat WA, Huysmans DA, Van den Bosch HC, et al. Pretreatment with a single, low dose of recombinant human thyrotropin allows dose reduction of radio-iodine therapy in patients with nodular goiters[J]. J Clin Endocrinol Metab, 2003, 88(4):3121-3129.
    [14] Duick DS, Baskin HJ. Utility of recombinant human thyrotropin for augmentation of radio-iodine uptake and treatment of nontoxic and toxic multinodular goiters[J]. Endocr Pract, 2003, 9:204-209.
    [15] Silva MN, Rubio IG, Romao R, et al. Administration of a single dose of recombinant human thyrotrophin enhances the efficacy of radioiodine treatment of large compressive multinodular goitres[J]. Clin Endocrinol (Oxf), 2004, 60(3):300-308.
    [16] Nielsen VE, Bonnema SJ, Boel-Jorgensen H, et al. Recombinant human thyrotropin (rhTSH)markedly changes the 131I kinetics during 131I therapy of patients with nodular goiter.. An evaluation by a randomized double-blinded trial[J]. J Clin Endocrinol Metab, 2004, 90(1):79-83.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1447) PDF downloads(2) Cited by()

Related
Proportional views

Potential therapeutic uses for rhTSH in thyroid diseases

  • Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Abstract: Currently, recombinant human TSH (rhTSH) is only approved in USA and Europe for diag-nostic monitoring of differentiated thyroid cancer patients. However, there are many other potential uses for rhTSH, including facilitation of treatment of patients with thyroid cancer and nodular goiter. The therapeutic role of rhTSH in patients with differentiated thyroid cancer and nodular goiter will be discussed in this review.

    HTML

Reference (16)

Catalog

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return