Volume 26 Issue 5
Oct.  2002
Article Contents

Citation:

The recent research progress of MIBG and its derivatives

  • Received Date: 2001-03-16
  • MIBG (metaiodobenzylguanidine)is a functional analog of the neurotransmitter norepinephrine.It is trans-ported,stored and rel eased by a mechanism similar to that of norepinephrine.MIBG and its derivatives are useful radio-pharmaceutical for the clinical scintigraphy and treatment of neural crest tumors such as pheochromocytoma and neurob-lastoma.Also it is applicable for myocardial imaging in evaluating the integrity and function of my ocardial presynapse sympathetic neuron.
  • 加载中
  • [1] Vaidyanathan G, Zhao XG, Larsen RH, et al. 3-[211At]-astato-4-fluorobenzylguanidine:a potential therapeutic agent with prolonged retention by neuroblastoma cells[J]. Br J Cancer, 1997, 76(2):226-233.
    [2] Cunningham SH, Maris RJ, Wheldon TE, et al. Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissio[J]. Br J Cancer, 1998, 77(12):2016-2018.
    [3] Zhuang ZP, Kung MP, Mu MU, et al. 99Tcm-labelled MIBG derivatives:Novel 99Tcm complexes as myocardial imaging agents for sympathetic neurons[J]. Bioconjugate Chem, 1999,10(2):159-168.
    [4] Stevens MJ, Raffel DM, Allman KC, et al. Regression and progression of cardiac sympathetic dysinnervation complicating diabetes:an assessment by C-11 hydroxyephedrine and positron emission tomography[J]. Metabolism, 1999, 48(1):92-101.
    [5] Merlet P, Pouillart F, Dubois-Rande JD, et al. Sympathetic nerve alterations assessed with 123I-MIBG in the failing human heart[J]. J Nucl Med, 1999, 40:224-231.
    [6] Merlet P, Benvenuti C, Moyse D, et al. Prognostic value of MIBG imaging in idiopathic dilated cardiomyopathy[J]. J Nucl Med, 1999, 40:917-923.
    [7] Maunoury C, Agostini D, Acar P, et al. Impairment of cardiac neuronal function in children dilated cardiomyopathy:an 123I-MIBG scintigraphic Study[J]. J Ncul Med, 2000, 41:400-404.
    [8] Bengel FM, Barthel P, Matsunari I, et al. Kinetics of 123I-MIBG after acute myocardial infarction and reperfusion therapy[J]. J Nucl Med, 1999, 40:904-910.
    [9] Sakata K, Shirotani M, Yoshida H, et al. Cardiac sympathetic nervous system in early essential hypertension assessed by 123I-MIBG[J]. J Nucl Med, 1999, 40:6-11.
    [10] Estorch M, Camprecios M, Flotats A, et al. Sympathetic reinnervation of cardiac allografts evaluated by 123I-MIBG imaging[J]. J Nucl Med, 1999, 40:911-916.
    [11] Takatsu H, Nishida H, Matsuo H, et al. Cardiac sympathetic denervation from the early stage of Parkinson's disease:clinical and experimental studies with radiolabelled MIBG[J]. J Nucl Med, 2000, 41(1):71-77.
    [12] Druschky A, Hilz MJ, Platsch G, et al. Differentiation of Parkinson's disease and multiple system atrophy in early disease stages by means of I-123-MIBG SPECT[J]. J Neurol Sci, 2000, 175(1):3-12.
    [13] Reinhardt MJ, Jungling FD, Krause TM, et al. Scintigraphic differentiation between two forms of primary dysautonomia early after onset of autonomic dysfunction:value of cardiac and pulmonary iodine-123 MIBG uptake[J]. Eur J Nucl Med, 2000, 27(5):595-600.
    [14] Owens J, Bolster AA, Prosser JE, et al. No-carrier-added 123I-MIBG:an initial clinical study in patients with phaeochromocytoma[J]. Nucl Med Commun, 2000, 21(5):437-440.
    [15] Kuin A, Rutgers M, van der Valk MA, et al. Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG)[J]. Br J Cancer, 1999, 79(5-6):802-806.
    [16] Boyd M, Cunningham SH, Brown MM, et al. Noradrenaline transporter gene transfer for radiation cell kill by 131I metaiodobenzylguanidine[J]. Gene Ther, 1999, 6(6):1147-1152.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1475) PDF downloads(2) Cited by()

Related
Proportional views

The recent research progress of MIBG and its derivatives

  • Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China

Abstract: MIBG (metaiodobenzylguanidine)is a functional analog of the neurotransmitter norepinephrine.It is trans-ported,stored and rel eased by a mechanism similar to that of norepinephrine.MIBG and its derivatives are useful radio-pharmaceutical for the clinical scintigraphy and treatment of neural crest tumors such as pheochromocytoma and neurob-lastoma.Also it is applicable for myocardial imaging in evaluating the integrity and function of my ocardial presynapse sympathetic neuron.

    HTML

Reference (16)

Catalog

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return