Volume 27 Issue 2
Apr.  2003
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Citation:

Studies on the molecular pathogenesis of radiation pulmonary fibrosis

  • Received Date: 2002-08-16
  • Radiation pulmonary fibrosis(RPF) is a frequent side effect of thoracic radiotherapy for breast neoplasm and total body irradiation before bone marrow transplantation. Studies on its pathogenesis have arrived at molecular level. Many cytokines, adhesion molecules and vasoactive substances all play important role in the course of RPF. Moreover, there exists genetic loci that has relation with RPF. Furthermore, studies on the molecular pathogenesis of RPF have pro? vided new ideas and new measures for the precaution and therapy of RPF.
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  • [1] Bitterman PB, Adlberg S, Crystal RG. Mechanisms of pulmonary fibrosis[J]. J Clin Invest, 1983, 72:1801-1806.
    [2] Philip R, Carl JJ, Jacqueline P, et al. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis[J]. Int J Radiat Oncol Biol Phys, 1995, 33(1):99-109.
    [3] Michele M, Jean-louse L, Sylvie D, et al. TGF-β1 and radiation fibrosis:a master switch and a specific therapeutic target?[J]. Int J Radiat Oncol Biol Phys, 2000, 47(2):277-290.
    [4] El-Gamel A, Award PS, Yonan NA, et al. Transforming growth factor-beta (TGF-beta1) genotype and lung allograft fibrosis[J]. J Heart Lung Transplant, 1999, 18(6):517-523.
    [5] Roberts AB, Piek E, Bottinger EP, et al. Is Smad3 a major player in signal transduction pathways leading to fibrogene-sis?[J]. Chest, 2001, 120(1 suppl):43s-47s.
    [6] Verrecchia F, Mauviel A. Transforming growth factor-β signaling through the smad pathway:role in extracellular matrix gene expression and regulation[J]. J Invest Derma,2002, 118(2):211-215.
    [7] Ghosh AK, Yuan WH, Mori Y, et al. Antagonistic regulation of type I collagen gene expression by interferon-γ and transforming growth factor-β[J]. J Biol Chem, 2001, 276(14):11041-11048.
    [8] Zhang Y, Feng XH, Rik D. Smad3 and Smad4 cooperate with c-jun/c-fos to mediate TGF-β-induced transcription[J]. Nature, 1998, 394(27):909-913.
    [9] Michael B, Datto W, Yong Y, et al. Functional analysis of the transforming growth factor responsive elements in the WAF1/Cip1/P21 promoter[J]. J Biol Chem, 1995, 270(48):28623-28628.
    [10] Johnston CJ, Williams JP, Okunieff P. Radiation-induced pulmonary fibrosis:examination of chemokine and chemokine receptor families[J]. Radiat Res, 2002, 157(3):256-265.
    [11] Hallahan DE, Geng L, Shyr Y. Effects of intercellular adhesion molecule 1(ICAM-1) null mutation on radiation-induced pulmonary fibrosis and respiratory insufficiency in mice[J]. J Natl Cancer Inst, 2002, 94(10):733-741.
    [12] Song LW, Wang DW, Cui XM, et al. Kinetic alterations of angiotensin-Ⅱ and nitric oxide in radiation pulmonary fibro-sis[J]. J Environ Pathol Toxicol Oncol, 1998,17(2):141-150.
    [13] Molteni A, Moulder JE, Cohen EF, et al. Control of radia-tion-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin Ⅱ type 1 receptor blocker[J]. Int J Radiat Biol, 2000, 76(4):523-532.
    [14] Haston CK, Zhou X, Gumbiner-Russo L. Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis[J]. Cacer Res, 2002, 62(13):3782-3788.
    [15] Mori M, Kida H, Morishita H, et al. Microsatellite instability in transforming growth factor-beta 1 type I receptor gene in alveolar lining epithelial cells of idiopathic pulmonary fibro-sis[J]. Am J Respir Cell Mol Biol, 2001, 24(4):398-404.
    [16] Haase M, Geyer P, Appold S, et al. Down-regulation of SP1 DNA binding activity in the process of radiation-induced pulmonary fibrosis[J]. Int J Radiat Biol, 2000, 76(4):487-492.
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Studies on the molecular pathogenesis of radiation pulmonary fibrosis

  • Institute of Radiation Medicine, Academy Military Medical Science, Beijing 100850, China

Abstract: Radiation pulmonary fibrosis(RPF) is a frequent side effect of thoracic radiotherapy for breast neoplasm and total body irradiation before bone marrow transplantation. Studies on its pathogenesis have arrived at molecular level. Many cytokines, adhesion molecules and vasoactive substances all play important role in the course of RPF. Moreover, there exists genetic loci that has relation with RPF. Furthermore, studies on the molecular pathogenesis of RPF have pro? vided new ideas and new measures for the precaution and therapy of RPF.

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