Volume 25 Issue 5
Oct.  2001
Article Contents

Citation:

Effects of ionizing radiation on central nervous system

  • Received Date: 2001-07-31
  • In the present paper we briefly reviewed the effects of ionizing radiation on central nervous system (CNS), including the effects of ionizing radiation on the developmental CNS,neurons, neural stem cells and gliocytes, the radioreponses of CNS injury and so on.
  • 加载中
  • [1] Hossain M, Uma Devi P. Effect of irradiation at the early foetal stag on adult brain function of mouse:learning and memory[J]. Int J Radiat Biol, 2001, 77:581-585.
    [2] Sun XZ, Takahashi S, Fukui Y, et al. Differernt patterns of abnormal neuronal migration in the cerebral cortex of mice prenatally exposed to irradiation[J].Brain Res Dev Bran Res, 1999, 114:99-108.
    [3] Abreu-Villaca YY, Schmidt SL. Effects of prenatal gamma irradiation on the development of the corpus callosum of Swiss mice[J]. Int J Dev Neurosci, 1999, 17:693-704.
    [4] Wang B, Takeda H, Gao WM, et al, Induction of apoptosis by beta radiation from tritium compounds in mous embryonic brain calls[J]. Health Phys, 1999, 77:16-23.
    [5] Desagher S, Glowinski, Premont J. Astrocytes protect neurons from hydrogen peroxide toxicity[J]. J Neurosci, 1996, 16:2553-2562.
    [6] Noel E, Gumin GJ, Raju U, et al. Increased expression of prohormone convertdase-2 in the irradiated rat brain[J]. FASEB J, 1998, 12:1725-1730.
    [7] Tada E, Yang C, Gobbel GT, et al. Long term impairment of subependymal repopulation following damage by ionizing irradiation[J]. Exp Neurol, 1999, 160:66-77.
    [8] Chow BM, Li YQ, Wong CS. Radiation-induced apoptosis in the adult central nervous system is p53-dependent[J]. Cell Death Differ, 2000, 7:712-720.
    [9] Li TQ, Wong CS. Radiation-induced apoptosis in the neonatal and adult rat spinal cord[J]. Radiat Res, 2000, 154:268-276.
    [10] Raju U, Gumin GJ, Noel E. et al. Failure of a second X-ray dose to activate nuclear factor κ B in normal rat astrocytes[J]. J Biol Chem, 1997, 272:24624-24630.
    [11] Iwata-Ichikawa E, Kondo Y, Miyazaki I, et al. Glial cells protect neurons against oxidative stress via transcriptional up-tegulation of the glutathione synhesis[J], J Neurochem, 1999, 72:2334-2344.
    [12] Nakagawa M, Bellinzona M, Seilhan TM, et al. Microglial responses after focal radiation-induced injury are affected by α-difloromethylornithine[J]. Int J Radiat Oncol Biol Phy, 1996, 36:113-123.
    [13] Raju U, Gumin GJ, Tofilon PJ. Activity and target gene expression in the rat brain after one and two exposures to ionizing radiation[J]. Radiat Oncol Invest, 1999, 7:145-152.
    [14] Tamatani M, Che YH, Matsuzaki H, et al. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NF κB activation in primary hippocampal neurons[J]. J Biol Chem, 1999, 274:8531-8538.
    [15] Cai L, Cherian MG, Iskander S, et al. Metallothionein induction in human CNS in vitro:neuroprotection from ionizing radiation[J]. Int J Radiat Biol, 2000, 76:1009-1017.
    [16] Guo Q, Sebastian L, Sopher BL, et al. Neurotrophic factors[activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation[J]. Proc Natl Acad Sci USA, 1999, 96:4125-4130.
    [17] Kojima S, Matsuki O, Nomura T, et al. Elevation of antioxidant potency in the brain of mice by low-dose γ-ray irradiation and its effect on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced brain damage[J]. Free Radic Biol Med, 1999, 26:388-395.
    [18] Heck S, Lezoualc'h F, Engert S, et al. Insulin-like growth facor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear facter κB[J]. J Biol Chem, 1999, 274:9828-9835.
    [19] Raju U, Gumin GJ, Tofilon PJ. Radiation-induced transcription factor activation in the rat cerebral cortex[J]. Int J Radiat Biol, 2000, 76:1045-1053.
    [20] Le WD, Xie WJ, Appel SH. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury[J]. J Neurosci Res, 1999, 56:652-658.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1136) PDF downloads(2) Cited by()

Related
Proportional views

Effects of ionizing radiation on central nervous system

  • MH Radiobiology Researeh Unit, Jilin University, Jilin Changchun 130021, China

Abstract: In the present paper we briefly reviewed the effects of ionizing radiation on central nervous system (CNS), including the effects of ionizing radiation on the developmental CNS,neurons, neural stem cells and gliocytes, the radioreponses of CNS injury and so on.

    HTML

Reference (20)

Catalog

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return