Volume 24 Issue 2
Apr.  2000
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Influence of radiation-induced apoptosis on development brain in molecular regulation

  • Received Date: 1999-01-13
  • An outline of current status on the influence of radiation on the development brain was given in the paper. Some genes as immediate early gene, Bcl-2 family, p53, heat shock protein and AT gene play an important regulation role in ionizing radiation-induced development brain cells apoptosis. And such biological factor as nerve growth factor, interlukin-l, tumor necrosis factor, basic fibroblast growth factor, transforming growth factor and so on have a vital protection function against ionizing radiation-induced cells apoptosis.
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  • [1] Peissner W,Kocher M,Treuer H,et al.Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus[J].Brain Res Mol Brain Res, 1999, 71(1):61~68.
    [2] Ferrer I. Cell death in the normal developing brain,and following ionizing radiation, methyl-azoxymethanol acetate, and hypoxia-ischaemia in the rat[J]. Neuropathol Appl Neurobiol,1996, 22(6):489~494.
    [3] Ferrer I,Olive M,Ribera J,et al.Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain[J]. Eur J Neurosci, 1996, 8(6):1286~1298.
    [4] Blank KR, Rudoltz MS, Kao GD, et al. The molecular regulation of apoptosis and implication for radiation oncology[J]. Int J Radiat Biol,1997, 71:455~466.
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    [6] Kitada S,Krajewski S,Miyashita T,et al.Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo[J]. Oncogene,1996, 12(1):187~192.
    [7] Yoshida T, Okazaki T, Hughes PE, et al. Cloning of rat Gadd45 gene and induction analysis following ionizing radiation in vivo[J]. FEBS Lett, 1996, 380(1-2):87~92.
    [8] Wang X,Matsumoto H,Okaichi K,et al.p53 aoccumulation in various organs of rats after whole-body exposure to low-dose X-ray irradiation[J].Anticancer Res, 1996, 16(4A):1671~1674.
    [9] Wang B, Takeda H, Gao WM, et al. Induction of apoptosis by beta radiation from tritium compounds in mouse embryonic brain cells[J]. Health Phys, 1999,77(1):16~23.
    [10] Jordan J, Galindo M F, Prehn JH, et al. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures[J]. J Neurosci, 1997, 17(4):1397~1405.
    [11] Ohnishi K, Matsumoto H, Takahashi A, et al. Heat shock transcription factor, HSF, is activated by ultraviolet irradiation[J]. Photochem Photobiol,1996, 64:949~952.
    [12] Herzog KH, Chong MJ, Kapsetaki M, et al.Requirment for Atmionizing radiation-induced in the developing central nervous system[J]. Science, 1998,280:1089~1091.
    [13] Chaing CS,Hong JH,Stalder A.Delayed molecular responses to brain irradiation[J]. Int J Radiat Biol,1997, 72:45~53.
    [14] Raju U, Gumin GJ, Tofilon PJ. NF kappa B activity and target gene expression in the rat brain after one and two exposures to ionizing radiation[J]. Radiat Oncol Investig, 1999, 7(3):145~l52.
    [15] Noel F, Ijiohi A, Chen JJ, et al. X-ray-rediated reduction in basic fibroblast growth expression in primary rat astrocyte cultures[J]. Radiat Res, 1997,147:484~489.
    [16] Jordan J, Galindo MF, Prehn JHM, et al. P53 expression induces apoptosis in hippocampal pyramidalneuron cultures[J]. J Neurosci, 1997, 17:1397~1405.
    [17] Nakagawa M, Bellinzona M,Seilhan TM, et al.Microglial responses after focal radiation-inducedinjury are affected by alpha-difluoromethylornithine[J]. Int J Radiat Oncol Biol Phys, 1996, 38:113~123.
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Influence of radiation-induced apoptosis on development brain in molecular regulation

  • Suzhou Children Hospital, Suzhou Medical College, Jiangsu Suzhou 215003, China

Abstract: An outline of current status on the influence of radiation on the development brain was given in the paper. Some genes as immediate early gene, Bcl-2 family, p53, heat shock protein and AT gene play an important regulation role in ionizing radiation-induced development brain cells apoptosis. And such biological factor as nerve growth factor, interlukin-l, tumor necrosis factor, basic fibroblast growth factor, transforming growth factor and so on have a vital protection function against ionizing radiation-induced cells apoptosis.

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