The reasearch status quo of tumor integrin αvβ3 receptor scintigraphy
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Nuclear Medicine Center, Southest Hospital, Third Military Medical University, Chongqing 400038, China
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Received Date:
2002-12-17
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Abstract
Integrin αvβ3 receptor is not only expressed on cells surface of many malignant tumors with higher level,but expressed on the neovasculature endothelial cell membrane in malignant tumor tissue with extremely high density and has no expression or cannot be detected in mature vascular endothelial cell and most of the normal organic system.The small molecul cyclic peptides containing RGD motif is an effective antagonist for αvβ3 receptor,which have height selectivity and affinity bind to αvβ3 receptor and is one kind of potential tumor receptor imaging agnet.
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