Volume 30 Issue 6
Dec.  2006
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Evaluation of the dose equivalent from patients with Graves' disease after 131Ⅰ therapy

  • Objective By calculating the dose equivalent to patients with Graves' disease by 131Ⅰ therapy, to evaluate the radiation safety of the individuals around the patients. Methods All patients had heed achieved the practical measure and follow-up, there attained the percentage of thyroid 131Ⅰ uptake, the 131Ⅰ dose, the duration of constrained social activity, and practical measure the effective dose equivalent rate and contact exact time with others, and compared the exposure dose to the individuals with the simplistic formula and practical measure accumulating dose calculating methods. Results For all patients with Graves' disease, the exposure doses to the individuals were not likely to exceed normal, Practical measure accumulating doses is higher than the simplistic formula calculating ones (t=3.953, P<0.001). When the adults' contact restricted time with the patients not exceed 6 days, practical measure accumulating calculating doses is higher (t=3.894, P<0.001), but exceed 6 days and enfant (commonly restricted), there were no difference between the simplistic formula calculating doses and practical measure accumulating calculating ones (t1=0.910, t2=1.705, respectively P>0.05). Conclusions All patients with 131Ⅰ therapy were safety to the individuals surrounding to the patients, practical measure accumulating doses is better and more practical.
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  • [1] Singer PA, Crooper DS, Levy EC, et al. Treatment guidelines for patients with hyperthyroidism and hypothyoidism. JAMA, 1995,273(10):808-812.
    [2] 李险峰,晋建华,张东红,等.甲状腺疾病131I治疗的辐射危害评价.中华核医学杂志,2004,24(3):191.
    [3] Coover LR, Silberstein EB, Kuhn PJ, et al. Therapeutic 131Ⅰ in outpatients:a simplified method conforming to the code of federal regulations, title 10, part 35.75. J Nucl Med, 2000, 41(11):1868-1875.
    [4] US Nuclear Regulatory Commission. 10 CFR Part 35.75:Release of individuals containing unsealed byproduct material or implants containing byproduct material. Washington DC:US Government Printing Office, 2000.
    [5] Friedman MI, Ghesani M. Interactive software automates personalized radiation safety plans for Na131Ⅰ therapy. Health Phys,2002, 83(11Suppl):S71-S84.
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Evaluation of the dose equivalent from patients with Graves' disease after 131Ⅰ therapy

    Corresponding author: LI Xian-feng, lixianfeng-lxf@263.net
  • 1. Department of Nuclear Medicine, the First Hospital of Shanxi Medical University, Taiyuan 030001, China;
  • 2. Department of Nuclear Medicine, the Chief Hospital of Taiyuan Steel Company, Taiyuan 030003, China

Abstract: Objective By calculating the dose equivalent to patients with Graves' disease by 131Ⅰ therapy, to evaluate the radiation safety of the individuals around the patients. Methods All patients had heed achieved the practical measure and follow-up, there attained the percentage of thyroid 131Ⅰ uptake, the 131Ⅰ dose, the duration of constrained social activity, and practical measure the effective dose equivalent rate and contact exact time with others, and compared the exposure dose to the individuals with the simplistic formula and practical measure accumulating dose calculating methods. Results For all patients with Graves' disease, the exposure doses to the individuals were not likely to exceed normal, Practical measure accumulating doses is higher than the simplistic formula calculating ones (t=3.953, P<0.001). When the adults' contact restricted time with the patients not exceed 6 days, practical measure accumulating calculating doses is higher (t=3.894, P<0.001), but exceed 6 days and enfant (commonly restricted), there were no difference between the simplistic formula calculating doses and practical measure accumulating calculating ones (t1=0.910, t2=1.705, respectively P>0.05). Conclusions All patients with 131Ⅰ therapy were safety to the individuals surrounding to the patients, practical measure accumulating doses is better and more practical.

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