Volume 33 Issue 6
Dec.  2009
Article Contents

Citation:

Bystander effect induced by ionizing radiation and its application

  • Received Date: 2009-08-05
  • An indirect effect induced by ionizing radiation called bystander effect is being highly concentrated. Many domestic and foreign researchers have verified the existence of bystander effect and have got more understanding of the mechanism with advanced detection techniques and methods. So far, the research about it has expanded from a single cell to multiple cells, from the in vitro to the whole, and has extended to in vivo from in vitro, which provides powerful evidence to explain how bystander effects happen and the regulation mechanism and especially gives scientific evidence to clinical radiation oncology application in the future.
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    [7] Wang Z,Cook T,Alber S,et al.Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity.Cancer Res,2004,64(4):1386-1395.
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    [10] Vines AM,Lyng FM,McClean B,et al.Bystander signal production and response are independent processes which are cell line dependent.Int J Radiat Biol,2008,84(2):83-90.
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    [15] Koturbash I,Loree J,Kutanzi K,et al.In vivo bystander effect:cranial X-irradiation leads to elevated DNA damage,altered cellular proliferation and apoptosis,and increased p53 levels in shielded spleen.Cell Cycle,2008,70(2):554-562.
    [16] Ilnytskyy Y,Koturbash I,Kovalchnk O.Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner.Environ Mol Mutagen,2009,50(2):105-113.
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Bystander effect induced by ionizing radiation and its application

  • Department of Medical Radioprotection, School of Radiation Medicine and Public Health, Suzhou 215123, China

Abstract: An indirect effect induced by ionizing radiation called bystander effect is being highly concentrated. Many domestic and foreign researchers have verified the existence of bystander effect and have got more understanding of the mechanism with advanced detection techniques and methods. So far, the research about it has expanded from a single cell to multiple cells, from the in vitro to the whole, and has extended to in vivo from in vitro, which provides powerful evidence to explain how bystander effects happen and the regulation mechanism and especially gives scientific evidence to clinical radiation oncology application in the future.

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