Volume 33 Issue 4
Aug.  2009
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Article Navigation >  Int J Radiat Med Nucl Med  > 2009,  33 > 4: (210-214)  

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Advances on functional neuroimaging in substance misuse

  • 1. Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;

  • 2. College of Chemistry, Beijing Normal University, Beijing 100875, China

  • Over the past decade, functional neuroimaging has contributed greatly to our knowledge about the neuropharmacology of substance misuse in man. In this review, discussed the application and the progress of the positron emission tomography, single photon emission computed tomography and functional magnetic resonance imaging in the substance misuse. After reading some papers, found that the dopamine transporter was significantly decreased in the brain of subjects with heroin abuse. Also observed a significant decrease of regional cerebral blood flow in bilateral cerebral frontal lobes, temporaJ lobes, the insula and the ipsilateral basal nuclei in substance misuse subjects. Taken together, functional images will lead the direction in future research formedication development of addiction treatment.
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  • [1] 王绪轶,郝伟.药物成瘾的功能影像学研究进展.中国药物依赖性杂志,2006,15(1):9-12.
    [2] Volkow ND,Fowler JS,Wang GJ,et al.Role of dopamine,the frontal cortex and memory circuits in drug addiction:insist from imaging studies.Neurobiol Leam Mem,2002,78(3):610-624.
    [3] 田嘉禾.PET与戒毒研究.中国医学计算机成像杂志,2004,10(5):345-351.
    [4] Wilson SJ,Sayette MA,Fiez JA.Prefrontal responses to drug cues:a neurocognitive analysis.Nat Neurosci,2004,7(3):211-214.
    [5] Volkow ND,Wang GJ,Ma Y,et al.Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers.J Neurosci,2003,23(36):11461-11468.
    [6] Mass LC,Lukas SE,Kaufman MJ,et al.Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving.Am J Psychiatry,1998,155(1):124-126.
    [7] Febo M,Segarra AC,Nair G,et al.The neural consequences of repeated cocaine exposure revealed by functional MRI in awake rats.Neuropsychopharmacology,2005,30(5):936-943.
    [8] Volkow ND,Wang GJ,Fowler JS,et al.Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects.Nature,1997,386(6627):830-833.
    [9] Friedman SD,Castañeda E,Hodge GK.Long-term monoamine depletion,differential recovery,and subtle behavioral impairment following methamphetamine-induced neurotoxicity,pharmacol Biochem Behav 1998,61(1):35-44.
    [10] Völlm BA,de Araujo IE,Cowen PJ,ct al.Methamphetamine activates rewardcircuilry in drugnaïe human subjects.Neuropsych-opharmacology,2004,29(9):1715-1722.
    [11] Fowler JS,Volkow ND,Wang GJ,et al.Inhibition of monoamine oxidase B in the brains of smokers.Nature,1996,379(6567):733-736.
    [12] Due DL,Huettel SA,Hall WG,et al.Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues; evidence from functional magnetic resonance imaging.Am Jpsychiatry,2002,159(6):954-960.
    [13] Kling MA,Careon RE,Borg L,et al.Opioid receptor imaging with positron emission tomography and[18F] cyclofoxy in long-term,methadone-treated former heroin addicts.J Pharmacol Exp Ther,2000,295(3):1070-1076.
    [14] Melichar JK,Hume SP,Williams TM,et al Using[11c] diprenorphine to image opioid receptor occupancy by methadone in opioid addiction:clinical and preclinical studies.J Pharmacol Exp Ther,2005,312(1):309-315.
    [15] Weiss F,Lorang MT,Bloom FE,et al.Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens:genetic and motivational determinants.J Pharmacol Exp Ther,1993,267(1):250-258.
    [16] George MS,Anton RF,Bloomer C,et al.Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues.Arch Gen Psychiatry,2001,58(4):345-352.
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Advances on functional neuroimaging in substance misuse

    Corresponding author: LIU Xing-dan, xingdiiu@yahoo.com
  • 1. Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;
  • 2. College of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received Date: 2009-01-24

Abstract: Over the past decade, functional neuroimaging has contributed greatly to our knowledge about the neuropharmacology of substance misuse in man. In this review, discussed the application and the progress of the positron emission tomography, single photon emission computed tomography and functional magnetic resonance imaging in the substance misuse. After reading some papers, found that the dopamine transporter was significantly decreased in the brain of subjects with heroin abuse. Also observed a significant decrease of regional cerebral blood flow in bilateral cerebral frontal lobes, temporaJ lobes, the insula and the ipsilateral basal nuclei in substance misuse subjects. Taken together, functional images will lead the direction in future research formedication development of addiction treatment.

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