血栓形成与细胞凋亡显像的研究进展

蒋宁一; 陈贵兵

血栓形成与细胞凋亡显像的研究进展

蒋宁一 , 陈贵兵

文章导航 > 国际放射医学核医学杂志 > 2003, 27 > 6: (248-251)

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血栓形成与细胞凋亡显像的研究进展

蒋宁一¹,
陈贵兵²

1. 510120 广州, 中山大学附属第二医院核医学科;
2. 510120 广州, 中山大学附属第二医院

作者简介: 蒋宁一(1954-),男,主任,教授,硕士生导师,主要从事临床核医学诊断和治疗研究;陈贵兵(1974-),男,硕士研究生,主要从事核素显像研究。;

中图分类号: R817.4

Progress on thrombosis and imaging of apoptosis

JIANG Ning-yi¹,
CHEN Gui-bing²

Department of Nuclear Medicine, The Second Affiliated Hosipital, Zhongshan University, Guangzhou 510120, China
CLC number: R817.4

摘要: 探讨了血栓形成与细胞凋亡的关系。作为一种新的功能显像技术,⁹⁹T^m-annexin V显像能通过检测凋亡细胞的存在而达到早期诊断血栓形成的目的,为临床血栓形成的早期诊断提供帮助。
- 血栓形成 /
- 细胞凋亡 /
- ⁹⁹Tc^m-annexin V
Abstract: This article discussed the correlation between apoptosis and thrombosis. As a new kind of functional imaging technology, the imaging of apoptosis with ⁹⁹T^m-labeled annexin V can be used to diagnose thrombosis in earlier period with detecting the existance of apoptosis cell. It also can offer the assistance about diagnosis of clinical thrombosed desease.
- thrombosis /
- apoptosis /
- ⁹⁹Tc^m-annexin V
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Takeya H, Tanaka Y, Suzuki K. Thrombosis and apoptosis[J]. Rinsho Byori, 1997, 45:614-620.
[2]	Tedgui A, Mallat Z. Acute coronary thrombosis[J]. Rev Prat,2003, 53(6):602-606.
[3]	Greeno EW, Bach RR, Moldow CF. Apoptosis is associated with increased cell surface tissue factor procoagulant acitivity[J]. Lab Invest, 1996, 75:281-289.
[4]	Wang J, Weiss I, Svoboda K, et al. Thrombogenic role of cells undergoing apoptosis[J]. Br J Haematol, 2001, 115(2):382-391.
[5]	Tedgui A, Mallat Z. Apoptosis as a determinant of atherothrombosis[J]. Thromb Haemost, 2001, 86:420-426.
[6]	Ananyeva NM, Kouiavskaia DV, Shima M, et al. Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque[J]. Blood, 2002, 99(12):4475-4485.
[7]	Bombeli T, Karsan A, Tait JF, et al. Apoptotic vascular endothelial cells become procoagulant[J]. Blood, 1997, 89:2429-2442.
[8]	Mallat Z, Tedgui A. Current perspective on the role of apoptosis in atherothrombotic disease[J]. Circ Res, 2001, 88(10):998-1003.
[9]	Uzan A. Thrombosis and ischemia:experimental data[J].Arch Mal Coeur Vaiss, 2002, 95(7):31-35.
[10]	Crumpton MJ, Dedman JR. Protein terminology tangle[J].Nature, 1990, 345:212.
[11]	Peng L, Jiang H, Bradely C. Detection of B lymphoma cells undergoing apoptosis by Annexin-V assay[J]. Chin Med Sci J, 2002,17(1):17-21.
[12]	Blankenberg FG, Katsikis PD, Tait JF, et al. In vivo detection and imaging of phosphatidylserine expression during programmed cell death[J]. Proc Natl Acad Sci USA, 1998,95:6349-6354.
[13]	Blankenberg FG, Katsikis PD, Tait JF, et al. Imaging of apoptosis (programmed cell death) with 99m-Tc annexin V[J]. J Nucl Med, 1999, 40:184-191.
[14]	Vriens PW, Blankenberg FG, Stoot JH, et al. The use of technetium Tc annexin V for in vivo imaging of apoptosis during cardiac allograft rejection[J]. J Thorac Cardiovasc Surg, 1998, 116:844-853.
[15]	Belhocine T, Steinmetz N, Hustinx R, et al. Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis[J]. Clin Cancer Res, 2002,8(9):2766-2774.
[16]	Ohtsuki K, Akashi K, Aoka Y, et al. Technetium-99m HYNIC-annexin V:a potential radiopharmacentical for the in-vivo detection of apoptosis[J]. Eur J Nucl Med, 1999, 26:1251-1258.
[17]	Blankenberg FG, Ohsuki K, Strauss HW. Dying a thousand deaths, Radionuclide imaging of apoptosis[J]. J Nucl Med,1999, 43:170-176.
[18]	Stratton JR, Dewhurst TA, Kasina S, et al. Selective uptake of radiolabeled annexin V on acute porcine left artial thrombi[J]. Circulation, 1995, 92:3113-3121.
[19]	Schellenberger EA, Bogdanov A Jr, Hogemann D, et al.Annexin V-CLIO:a nanoparticle for detecting apoptosis by MRI[J]. Mol Imaging, 2002, 1(2):102-107.
[20]	Glaser M, Collingridge DR, Aboagye EO, et al. Iodine-124labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography[J]. Appl Radiat Isot, 2003, 58(1):55-62.

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