<sup>99m</sup>Tc标记annexin V类显像剂细胞凋亡显像在肿瘤研究中的应用及进展

张欣; 李亚明

^99mTc标记annexin V类显像剂细胞凋亡显像在肿瘤研究中的应用及进展

张欣 , 李亚明

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 4: (210-213)

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^99mTc标记annexin V类显像剂细胞凋亡显像在肿瘤研究中的应用及进展

张欣¹,
李亚明^2, ,

1. 116011 大连, 大连医科大学附属第一医院核医学科;
2. 110001 沈阳, 中国医科大学附属第一医院核医学科

通讯作者: 李亚明, ym1i2001@163.com

中图分类号: R817.4

Application and advance of apoptosis ^99mTc labelled annexin V imaging in tumor research

ZHANG Xin¹,
LI Ya-ming^2, ,

1. Department of Nuclear Medicine, The First Hospital Affiliated to Dalian Medical University, Dalian 116011, China;
2. Department of Nuclear Medicine, The First Hospital Affiliated to China Medical University, Shenyang 110001, China

Corresponding author: LI Ya-ming, ym1i2001@163.com

CLC number: R817.4

摘要: 细胞凋亡在肿瘤的发生发展过程中起着重要的作用,成功的肿瘤治疗将在肿瘤组织内诱导肿瘤细胞产生凋亡。^99mTc标记annexin V类显像剂凋亡显像能够在体内早期、无创伤性地检测到治疗所引起的细胞凋亡,这将有助于早期评判肿瘤患者的治疗效果及预后。
- 钙磷脂结合蛋白V /
- 细胞凋亡 /
- 肿瘤
Abstract: Apoptosis plays an important role in tumor processes. Successful therapy induces apoptosis of neoplastic cells in tumor tissue. Apoptosis ^99mTc labelled annexin V imaging enables noninvasive in vivo detect treatment-induced apoptosis on the early stage. It will be useful in early assessment the efficacy of cancer therapies and disease prognosis in individual patients.
- Annexin V /
- Apoptosis /
- Neoplasms
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Narula J,Strauss HW.Implications of phosphatidyl serine (PS) reversal in acute ischemic syndromes.J Nucl Med,2003,44(3):397-399.
[2]	England M,Neiland LJW,Ramaekers FCS,et al.Annexin Ⅴ-affinnity assay:a review apoptosis detection system based on phosphatidylserine exposure.Cytometry,1998,31(1):1-9.
[3]	Kemerink GJ,Boersma HH,Thimister PWL,et al.Biodistribution and dosimetry of ^99mTc-BATP-annexin Ⅴ in humans.Eur J Med,2001,28(9):1373-1378.
[4]	Belhocine T,Steinmetz N,Huatinx R,et al.Increased uptake of the apoptosis-imaging agent 99mTc recombinant human Annexin Ⅴ in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis.Clin Cancer Res,2002,8(9):2766-2774.
[5]	Van de Wiele C,Lahorte C,Vermeersch H,et al.Quantitative tumor apoptosis imaging using Technetium-99m-HYNIC Annexin V single photon emission computed tomography.J Clin Oncol,2003,21(18):3483-3487.
[6]	Vermeersh H,Loose D,Lahorte C,et al.^99mTc-HYNIC-Annexin Ⅴ imaging of primary head and neck carcinoma.Nucl Med Commun,2004,25(3):259-263.
[7]	Mochizuki T,Kuge Y,Zhao S,et al.Detection of apoptotic tumor response in vivo after a single dose of chemotherapy with ^99mTc-Annexin Ⅴ J NuclMed,2003,44(1):92-97.
[8]	Mochizuki T,Kuge Y,Zhao S,et al.Detection of apoptotic tumor response following a single dose of chemotherapy with ^99mTc-Annexin V.J Nucl Med,2001,42(suppl):84.
[9]	Yang DJ,Azhdarinia A,Wu P,et al.In vivo and in vitro measurement of apoptosis in breast cancer cells using ^99mTc-EC-Annexin V.Cancer Biother Radiopharm,2001,16(1):73-83.
[10]	Ohtsuki K,Akashi K,Aoka Y,et al.^99mTc-HYNIC-Annexin Ⅴ:a potential radiopharmaceutical for the in-vivo detection of apoptosis.Eur J Nucl Med,1999,26(10):1251-1258.
[11]	Kuge Y,Sato M,Zhao S,et al.Feasibility of ^99mTc-Annexin Ⅴ for repetitive detection of apoptotic tumor response to chemotherapy:an experi mental study using a rat tumor model.J Nucl Med,2004,45(2):309-313.
[12]	Takei T,Kuge Y,Zhao S,et al.Enhanced apoptosis reaction correlates with suppressed tumor glucose utilization after cytotoxic chemotherapy:use of 99mTcm-Annexin Ⅴ,¹⁸F-FDG,and histolog-ic evaluation.J Nucl Med,2005,46(5):794-799.
[13]	Haberkorn U,Bellemann ME,Brix G,et al.Apoptosis and changes in glucose transport early after treatment of Morris hepatoma with gemcitabine.Eur J Nucl Med,2001,28(4):418-425.
[14]	Kemerink GJ,Liu X,Kieffer D,et al.Safety,biodistribution,and dosimetry of ^99mTc-HYNIC-Annexin Ⅴ,a novel human recombinant Annexin Ⅴ for human application J Nucl Med,2003,44(6):947-952.
[15]	Kartachova M,Haas R,Olmos R,et al.In vivo imaging of apoptosis by 99mTc-Annexin Ⅴ scintigraphy:visual analysis in relation to treatment response.Radiother Oncol,2004,72(3):333-339.

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