放射免疫治疗计划研究
Study of Treatment planning for radio-immunotherapy
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摘要: 放射免疫治疗(RIT)计划是通过收集治疗前病人的特定信息如活度分布等来指导具体治疗,它的目的是使病人的肿瘤灶得到治疗剂量的同时周围的重要器官在耐受量以内。要得到好的RIT疗效,必须知道以下三点:带有放射性核素的载体在病人体内的空间分布和定量;在这种分布下肿瘤灶和重要器官的吸收剂量;用CT或MRI、以及CT或MRI与其它放射影像结合来获得肿瘤和重要器官的体积。本文总结和探讨了目前使用的各种放射免疫治疗计划及这些治疗计划中使用的活度定量方法、体积确定方法和吸收剂量计算方法。
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关键词:
- 放射免疫治疗计划 /
- 图像融合 /
- 剂量点核 /
- Monte Carlo输运
Abstract: RIT treatment planning is improve therapy by collecting patient-specific information (such as the activity distribution) before treatment. Its objective maximizes the dose absorbed by the tumor while minimizing the toxicity to normal tissue. To gain good healing effect in RIT, one needs to determine:the quantity and spatial distribution of the administered radionuclide carrier in the patient over time; the absorbed dose in the tumor sites and critical organs based on this distribution; the volume of tumor and critical organs from CT or MRI and appropriately correlated with nuclear medicine imaging techniques. This article conclude and discuse various RIT treatment planning used present and quantitation of activity, volume determination and calculation of absorbed dose that are used in these treatment planning. -
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