电离辐射诱发的基因组不稳定性与辐射致癌

王仲文

电离辐射诱发的基因组不稳定性与辐射致癌

王仲文

文章导航 > 国际放射医学核医学杂志 > 2000, 24 > 5: (226-230)

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电离辐射诱发的基因组不稳定性与辐射致癌

王仲文

030006 山西太原, 中国辐射防护研究院

作者简介: 王仲文(1962-),男,中国辐射防护研究院副研究员,主要从事辐射生物效应的研究。;

基金项目:
核工业科学基金资助项目(J96Q61008)
中图分类号: Q345

Ionizing radiation induced genomic instability and its relation to radiation carcinogenesis

WANG Zhong-wen

China Institute for Radiation Protection, Taiyuan 030006, China
CLC number: Q345

摘要: 电离辐射诱发的基因组不稳定性在哺乳动物细胞和体内广泛的存在,使受照的细胞子代增加了遗传变化的频率。在辐射诱发小鼠白血病中,受预照射的CBA/H小鼠本身的白血病发生率与对照组相比并不显著,但子代小鼠中受γ射线照射后与单独受到γ射线照射的小鼠相比,白血病的潜伏期缩短,发病率增高。辐射诱发的基因组不稳定性可能使整基因组处于临界突变状态。随着基因组不稳定性过程使细胞内一些关键的基因(如癌基因活化,抑癌基因失活)突变,癌症发生。因此,基因组不稳定性在癌症的起始过程中作为一个关键的早期事件,可能起着特殊的,也许是独特的作用。
- 辐射 /
- 基因组不稳定性 /
- 微卫星序列 /
- p53
Abstract: There are widespread testimonies that the genomic instability induced by ionizing irradiation exits in mammal and its vitro cells. Genomic instability can enhance the frequency of genetic changes among the progeny of the original irradiated cells. In the radiation-leukaemogenesis, there is no significant difference between controls and CBA/H mouses of PPI (preconception patenal irradiation), but the offsprings of the PPI recipients show a different character (shorter latent period and higher incidence) after an extra γ-radiation. The radiation-induced genomic instability may get the genome on the verge of mutation and lead to carcinogenes following mutation of some critical genes. The genomic instability, as the early event of initiation of carcinomas, may be play a specific or u-nique role.
- ionizing radiation /
- genomic instability /
- p53 gene /
- minisatellite
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电离辐射诱发的基因组不稳定性与辐射致癌

王仲文

作者简介:王仲文(1962-),男,中国辐射防护研究院副研究员,主要从事辐射生物效应的研究。

030006 山西太原, 中国辐射防护研究院

收稿日期: 2000-03-07

基金项目: 核工业科学基金资助项目(J96Q61008)

关键词:

摘要: 电离辐射诱发的基因组不稳定性在哺乳动物细胞和体内广泛的存在,使受照的细胞子代增加了遗传变化的频率。在辐射诱发小鼠白血病中,受预照射的CBA/H小鼠本身的白血病发生率与对照组相比并不显著,但子代小鼠中受γ射线照射后与单独受到γ射线照射的小鼠相比,白血病的潜伏期缩短,发病率增高。辐射诱发的基因组不稳定性可能使整基因组处于临界突变状态。随着基因组不稳定性过程使细胞内一些关键的基因(如癌基因活化,抑癌基因失活)突变,癌症发生。因此,基因组不稳定性在癌症的起始过程中作为一个关键的早期事件,可能起着特殊的,也许是独特的作用。