应用生物标志对肿瘤辐射敏感性的研究

郭万峰 丁桂荣 韩良辅

引用本文:
Citation:

应用生物标志对肿瘤辐射敏感性的研究

    作者简介: 郭万峰(1974-),男,西安第四军医大学放射医学教研室硕士研究生;丁桂荣(1971-),女,西安第四军医大学放射医学教研室博士;韩良辅(1964-),男,西安第四军医大学西京医院放疗科博士。;
  • 中图分类号: Q691;R730.5

Application of biomarker to study on tumor radiosensitivity

  • CLC number: Q691;R730.5

  • 摘要: 为了实现肿瘤放射治疗方案的个体化,确定肿瘤的辐射敏感性是一个重要内容。许多实验室从不同水平研究了应用单个生物标志和多个生物标志在预测肿瘤辐射敏感性时的作用。虽然目前尚无特异性的生物标志,但提供了良好的研究模式。
  • [1] Bjork-Eriksson T, West C, Karlsson E, et al.Tumor radiosensitivity (SF2) is a prognostic factor for local control in head and neck cancers[J].Int J Radiat Oncol Biol Phys, 2000, 46(1):13-19.
    [2] Widel M, Jedrus S, Owczarek S, et al.The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability[J].Br J Cancer, 1999, 80(10):1599-1607.
    [3] Lee T, O'Brien KF, Naves JL, et al.Micronuclei in lymphocytes of prostate cancer patients undergoing radiation therapy[J].Mutat Res, 2000, 469(1):63-70.
    [4] Abend M, Rhein A, Gilbertz KP, et al.Correlation of micronucleus and apoptosis assay with reproductive cell death[J].Int J Radiat Biol, 1995, 67:315-326.
    [5] Verheij M, Bartelink H.Radiation-induced apoptosis[J].Cell Tissue Res, 2000, 301(1):133-142.
    [6] Levine EL, Davidson SE, Robert SA, et al.Apoptosis as predictor of response to radiotherapy in cervical carcinoma[J].Lancet, 1994, 344:472.
    [7] Zhivotovsky B, Joseph B, Orrenius S.Tumor radiosensitivity and apoptosis[J].Exp Cell Res, 1999, 248(1):10-17.
    [8] Olive PL, Durand RE.Apoptosis:an indicator of radiosensitivity in vitro?[J].Int J Radiat Biol, 1997, 71:695-707.
    [9] Schwartz JL, Murnane J, Weichselbaum RR.The contribution of DNA ploidy to radiation sensitivity inhuman tumour cell lines[J].Br J Cancer, 1999, 79(5-6):744-747.
    [10] Coco Martin JM, Mooren E, Ottenheim C, et al.Potential of radiation-induced chromosome aberraions to predict radiosensitivity in human tumour cells[J].Int J Radiat Biol, 1999, 75(9):1161-1168.
    [11] Dikomy E, Dahm-Daphi J, Martensen R, et al.1998, Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mam-malian cell lines[J].Int J Radiat Biol, 1998, 73(3):269-278.
    [12] Bistow RG, Benchimol S, Hill RP.The p53 gene as a modifier of intrinsic radiosensitivity:implications for radiotherapy[J].Radiother Oncol, 1996, 40(3):197-223.
    [13] Bae I, Smith ML, Sheikh MS, et al.An abnormality in the p53 pathway following γ-irradition in many wild-type p53 human melanoma lines[J].Cancer Res, 1996, 56(4):840-847.
    [14] Dahm-Daphi J.p53:biology and role for cellular radiosensitivity[J].Strahlenther Onkol, 2000, 176(6):278-285.
    [15] Kariya S, Ogawa Y, Yoshida S, et al.X-irradiation enhances the expression of Bcl-2 in HL-60 cells:The resulting effects on apoptosis and radiosensitivity[J].Int J Mol Med, 1999, 3(2):145-152.
    [16] Guo GZ, Sasai K, Oya N, et al.Simultaneous evaluation of radiation-induced apoptosis and micronuclei in five cell lines[J].Int J Radiat Biol, 1998, 73(3):297-302.
    [17] Guo GZ, Sasai K, Oya N, et al.A significant correlation between clonogenic radiosensitivity and the simul-taneous assessment of micronucleus and apoptotic cell frequencies[J].Int J Radiat Biol, 1999, 75(7):857-864.
    [18] Abend M, Kehe K, Riedel M, et al.Correlation of micronucleus and apoptosis assays with reproductive cell death can be improved by considering other modes of death[J].Int J Radiat Biol, 2000, 76(2):249-259.
    [19] Peltenburg LT.Radiosensitivity of tumor cells.Onco-genes and apoptosis[J].Q J Nucl Med, 2000, 44(4):355-364.
    [20] Achary MP, Jaggernauth W, Gross E, et al.Cell lines from the same cervical carcinoma but with different radiosensitivities exhibit different cDN A microarray patterns of gene expression[J].Cytogenet Cell Genet, 2000, 91(1-4):39-43.
    [21] Bjork-Eriksson T, West CM, Cvetskovska E, et al.The lack of correlation between proliferation(Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers[J].Br J Cancer, 1999, 80(9):1400-1404.
    [22] Levine EL, Renehan A, Gossiel R, et al.Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma[J].Radiother Oncol, 1995, 37(1):1-9.
    [23] Rosen EM, Fan S, Goldberg ID, et al.Biological basis of radiation sensitivity.Part 2:Cellular and molecular determinants of radiosensitivity[J].Oncology(Huntingt) 2000, 14(5):741-757; 757-758; 761-766.
  • [1] 刘谦白志杰伊晓勇 . 前列腺癌miRNA生物标志物及其与辐射敏感性的研究进展. 国际放射医学核医学杂志, 2017, 41(3): 227-231. doi: 10.3760/cma.j.issn.1673-4114.2017.03.013
    [2] 许建华 . Egr-1基因的辐射生物学效应研究进展. 国际放射医学核医学杂志, 2002, 26(2): 76-79.
    [3] 菅原努 . 提倡新模式的低剂量放射生物学. 国际放射医学核医学杂志, 1997, 21(z1): 193-195.
    [4] 朱光旭王小华 . 肿瘤辐射敏感性与细胞凋亡. 国际放射医学核医学杂志, 2000, 24(2): 78-82.
    [5] 王丽平梁克 . 细胞凋亡与辐射敏感性. 国际放射医学核医学杂志, 2000, 24(2): 75-78.
    [6] 杜维霞 . 辐射敏感性影响因素研究. 国际放射医学核医学杂志, 2003, 27(5): 238-240.
    [7] 陆克义李险峰 . 甲状腺疾病患者131I治疗后对他人的辐射危害评价. 国际放射医学核医学杂志, 2004, 28(5): 226-229.
    [8] 于文儒王继先 . 个体辐射敏感性差异的研究进展及意义. 国际放射医学核医学杂志, 1997, 21(2): 87-90.
    [9] 沈瑜 . 临床放射生物学的现状和未来. 国际放射医学核医学杂志, 1997, 21(z1): 217-221.
    [10] 陈洪雷彭勇 . 高压氧与肿瘤放射治疗. 国际放射医学核医学杂志, 2005, 29(6): 289-292.
  • 加载中
计量
  • 文章访问数:  1088
  • HTML全文浏览量:  117
  • PDF下载量:  2
出版历程
  • 收稿日期:  2001-04-13

应用生物标志对肿瘤辐射敏感性的研究

    作者简介:郭万峰(1974-),男,西安第四军医大学放射医学教研室硕士研究生;丁桂荣(1971-),女,西安第四军医大学放射医学教研室博士;韩良辅(1964-),男,西安第四军医大学西京医院放疗科博士。
  • 1. 710032 西安, 第四军医大学放射医学教研室;
  • 2. 710032 西安, 第四军医大学西京医院放疗科

摘要: 为了实现肿瘤放射治疗方案的个体化,确定肿瘤的辐射敏感性是一个重要内容。许多实验室从不同水平研究了应用单个生物标志和多个生物标志在预测肿瘤辐射敏感性时的作用。虽然目前尚无特异性的生物标志,但提供了良好的研究模式。

English Abstract

参考文献 (23)

目录

    /

    返回文章
    返回