siRNA与肿瘤放射治疗

刘光伟; 龚守良

siRNA与肿瘤放射治疗

刘光伟 , 龚守良

文章导航 > 国际放射医学核医学杂志 > 2004, 28 > 4: (169-172)

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siRNA与肿瘤放射治疗

130021 长春, 吉林大学卫生部放射生物学重点实验室
中图分类号: R730.55;Q691.9

siRNA and tumor radiotherapy

MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China
CLC number: R730.55;Q691.9

摘要: 近年来,放射肿瘤学研究者致力于采用特异性阻断剂阻断DNA修复程中关键调控基过因,并通过有效抑制DNA损伤修复,促进肿瘤细胞死亡,收到较好的肿瘤放疗效果。但是同时发现,阻断剂技术本身存在诸多缺陷,这极大地限制其尽快应用于临床肿瘤治疗。自小片段干扰核糖核酸(small interference RNA,siRNA)干涉技术发现以来,其强大的阻断真核细胞中特异表达蛋白的能力为众多研究者所关注。更重要的是,它较好地解决了应用阻断剂带来的上述问题,从而为肿瘤放射基因治疗研究提供了新途径。
- RNA干涉 /
- 肿瘤 /
- 放射治疗 /
- 基因
Abstract: Recently, many radio oncology researchers had gained some good curative effects on DNA damage repair inhibited and tumor cell death increased by blocking key control genes in the course of DNA repair with specific blocking agents. Otherwise, the blocking agents have many defects, which extremely limited its application on curing tumor. Since small interference RNA (siRNA) technology was discovered, its powerful function of blocking expressible specific protein in eukaryocytes was attented by many researchers. Meanwhile, this technology admirably resolved mentioned above problems caused by using the blocking agents, which provided a new way for tumor radio gene therapy.
- RNA interference /
- tumor /
- radiotherapy /
- gene
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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siRNA与肿瘤放射治疗

130021 长春, 吉林大学卫生部放射生物学重点实验室

收稿日期: 2004-01-17

关键词:

RNA干涉 /
肿瘤 /
放射治疗 /
基因

摘要: 近年来,放射肿瘤学研究者致力于采用特异性阻断剂阻断DNA修复程中关键调控基过因,并通过有效抑制DNA损伤修复,促进肿瘤细胞死亡,收到较好的肿瘤放疗效果。但是同时发现,阻断剂技术本身存在诸多缺陷,这极大地限制其尽快应用于临床肿瘤治疗。自小片段干扰核糖核酸(small interference RNA,siRNA)干涉技术发现以来,其强大的阻断真核细胞中特异表达蛋白的能力为众多研究者所关注。更重要的是,它较好地解决了应用阻断剂带来的上述问题,从而为肿瘤放射基因治疗研究提供了新途径。