干细胞因子的辐射防护作用及其机制

杨军

干细胞因子的辐射防护作用及其机制

杨军

文章导航 > 国际放射医学核医学杂志 > 2000, 24 > 4: (180-183)

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干细胞因子的辐射防护作用及其机制

杨军

510515 广州, 第一军医大学训练部教务处

作者简介: 杨军(1967-),男,河南光山人,医学硕士。研究方向:辐射细胞生物学与实验血液学。;

基金项目:
军队九·

五指令性课题(96L045)
中图分类号: R818.03

The effects and mechanism of radiation prevention of SCF

YANG Jun

Department of teaching, The First Military Medical University, Guangzhou 510515, China
CLC number: R818.03

摘要: 干细胞因子(SCF)不仅是维持生命活动所需要的,而且在抵抗电离辐射对机体的作用及修复辐射所致损伤中都是必不可少的。许多作者发现,SCF能明显改善受致死剂量照射动物的长期生存率,这种作用在与其它造血刺激因子和抗放剂协同作用时更为明显。目前认为,SCF的主要防护机制是可以抑制凋亡和促进细胞周期的进程,加速骨髓及外周血多种有效成分的增殖和分化等,且其抑制凋亡机制与p53、Ca²⁺内流及caspase的介导等有关。
- 干细胞因子 /
- 辐射防护 /
- 机制
Abstract: SCF is not needed by life, but also vital for prevention from ionic radiation and repairing of damage by radiation. It is discovered that SCF can distinctively elevate the survival ratio of animal irradiated by lethal dosage, especially when it cooperates with hemocytogenesis factor and anti-radiation agents. SCF can inhibit apoptosis, promote cell cycle, accelerate proliferation and differentiation of many factors in marrow and peripheral blood, as may be the protective mechanism of SCF. It's ability of apoptosis inhibition may be associated with p53, Ca²⁺ influx, and mediated by caspase.
- stem cell factor /
- radiation prevention /
- mechanism
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干细胞因子的辐射防护作用及其机制

杨军

作者简介:杨军(1967-),男,河南光山人,医学硕士。研究方向:辐射细胞生物学与实验血液学。

510515 广州, 第一军医大学训练部教务处

收稿日期: 1999-05-09

基金项目: 军队九·五指令性课题(96L045)

关键词:

摘要: 干细胞因子(SCF)不仅是维持生命活动所需要的,而且在抵抗电离辐射对机体的作用及修复辐射所致损伤中都是必不可少的。许多作者发现,SCF能明显改善受致死剂量照射动物的长期生存率,这种作用在与其它造血刺激因子和抗放剂协同作用时更为明显。目前认为,SCF的主要防护机制是可以抑制凋亡和促进细胞周期的进程,加速骨髓及外周血多种有效成分的增殖和分化等,且其抑制凋亡机制与p53、Ca²⁺内流及caspase的介导等有关。