基因组不稳定性与错配修复机制

沈波

基因组不稳定性与错配修复机制

沈波

文章导航 > 国际放射医学核医学杂志 > 2003, 27 > 2: (87-89)

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基因组不稳定性与错配修复机制

沈波

030006 太原, 中国辐射防护研究院生命科学研究所

作者简介: 沈波(1974-),女,硕士研究生,主要从事放射生物学研究。;

中图分类号: Q345⁺.2

Genomic instability and mismatch repair mechanism

SHEN Bo

China Institute for Radiation Protection, Taiyuan 030006, China
CLC number: Q345⁺.2

摘要: 辐射可以诱导细胞基因组发生不稳定性改变,表现为一系列的延迟突变表型。错配修复机制作为一种重要的复制后修复机制,在维持基因组稳定方面发挥着重要的作用。它是一种保守的修复机制,不仅可以通过异二聚体的形式直接参与修复过程,也可以通过cdc2磷酸化途径对细胞周期进行间接调控。因此,探讨基因组不稳定性与错配修复之间的相互关系,可能是我们深入了解电离辐射的损伤与修复机制的重要内容。
- 基因组不稳定性 /
- 错配修复 /
- 细胞周期阻滞
Abstract: Irradiation can induce genomic instability and produce a series of delayed mutations. As a free-error repair mechanism of post-duplication, mismatch repair plays an essential role in the maintenance of genomic stability. Mismatch is proposed a kind of conservative repair mechanism. Not only can it be involved in the repair process directly by heter-dimers, but it can affect the cell-cycle by cdc2 phophatized path to supervise the cell-cycle indirectly. Therefore, discussing the relation of genomic instability and mismatch repair may represent one of aspects of radiational damage and repair mechanisms
- genomic instability /
- mismatch repair /
- cell-cycle arrest
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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基因组不稳定性与错配修复机制

沈波

作者简介:沈波(1974-),女,硕士研究生,主要从事放射生物学研究。

030006 太原, 中国辐射防护研究院生命科学研究所

收稿日期: 2002-08-11

关键词:

摘要: 辐射可以诱导细胞基因组发生不稳定性改变,表现为一系列的延迟突变表型。错配修复机制作为一种重要的复制后修复机制,在维持基因组稳定方面发挥着重要的作用。它是一种保守的修复机制,不仅可以通过异二聚体的形式直接参与修复过程,也可以通过cdc2磷酸化途径对细胞周期进行间接调控。因此,探讨基因组不稳定性与错配修复之间的相互关系,可能是我们深入了解电离辐射的损伤与修复机制的重要内容。