实验性近视眼视网膜多巴胺神经系统研究进展

赵娟; 刘兴党

赵娟 , 刘兴党

文章导航 > 国际放射医学核医学杂志 > 2007, 31 > 2: (73-76)

引用本文:

Citation:

实验性近视眼视网膜多巴胺神经系统研究进展

赵娟,
刘兴党

200040 上海, 复旦大学附属华山医院核医学科
中图分类号: R-332

Study and development of retinal dopamine nervous system in experimental myopia

Department of Nuclear Medicine, Hua Shah Hospital, Fudan University, Shanghai, 200040, China
CLC number: R-332

摘要: 近视眼是一种最常见的屈光不正。动物实验模型主要包括形觉剥夺性近视和离焦性近视两种,应用的实验动物主要为鸡和哺乳类。视网膜多巴胺系统与视觉经验对出生后眼球生长发育的调控密切相关,而视网膜多巴胺转运体的变化可能更为直接地反映了突触间隙多巴胺的变化。
- 近视 /
- 模型,动物 /
- 视网膜 /
- 受体,多巴胺 /
- 多巴胺转运体 /
- 放射性核素显像
Abstract: Myopia is the most familiar ametropia. Animal experimental models include form deprivation myopia and defocus myopia. Experimental animals we often use are chicken and mammals. The retinal dopamine system and vision expierence have close relations with the regulation of eyeball's growth after birth, while the change ofdopamine transporter may reflect the change ofdopamine in the synaptic cleft more directly.
- Myopia /
- Models, animal /
- Retina /
- Receptor, dopamine /
- Dopamine transporter /
- Radionuclide imaging
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Wildsoet C, Wall man J. Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks. Vision Res, 1995, 35(9):1175-1194.
[2]	Schaeffel F, Bartmann M, Hagel G, et al. Studies of the retinal dopamine melatonin system in experimental refractive errors in chickens. Vision Res, 1995, 35(9):1247-1264.
[3]	Kee CS, Marzani D, Wallman J. Differences in time course and visual requirements of ocular responses to lenses and diffusers.Invest Ophthalmol Vis Sci, 2001, 42(3):575-583.
[4]	Tejedor J, de la Villa P. Refractive changes induced by form deprivation in the mouse eye. Invest Ophthalmol Vis Sci, 2003, 44(1):32-36.
[5]	欧阳朝祜,褚仁远,胡文政.哌仑西平对豚鼠透镜诱导性近视眼的作用.中华眼科杂志,2003,39(6):348-351.
[6]	Stone RA, Lin T, Laties AM, et al. Retinal dopamine and from deprivation myopia. Proc Natl Acad Sci USA, 1989, 86(2):704-706.
[7]	Seko Y, Tanaka Y, Tokoro T. Apomorphine inhibits the growth stimulating effect of retinal pigment epithelium on scleral cells in vitro. Cell Biochem Funct, 1997, 15(3):191-196.
[8]	Filippi L, Manni C, Pierantozzi M, et al. ¹²³Ⅰ-FP-CIT semiquantitative SPECT detects preclinical bilateral dopaminergic deficit in early Parkinson's disease with unilateral symptoms. Nucl Med Commun,2005, 26(5):421-426.
[9]	Bartmann M, Schaeffel F, Hagel G, et al. Constant light affects retinal dopamine levels and blocks deprivation myopia but not lens incluced refractive errors in chickens. Vis Neurosci, 1994, 11(2):199-208.
[10]	Ohngemach S, Hagel G, Schaeffel F. Concentrations of biogenic amines in fundal layers in chickens with normal visual experience,deprivation and after reserpine application. Vis Neurosci, 1997, 14(3):493-505.
[11]	XI Xiaoqing, CHU Renyuan, ZHOU Xingtao, et al. Retinal dopamine transporter in experimental myopia. Chin Med J, 2002, 115(7):1027-1030.
[12]	唐刚华.PET药物及其研究现状与进展.国外医学:放射医学核医学分册,1999,23(5):193-197.
[13]	Wang WF, Ishiwata K, Kiyosawa M, et al. Investigation of the use of positron emission tomography for neuroreceptor imaging in rabbit eyes. Ophthalmac Res, 2004, 36(5):255-263.

[1]	刘淼 , 刘兴党 . 视网膜神经受体及其分子显像研究进展. 国际放射医学核医学杂志, 2017, 41(5): 359-362, 369. doi: 10.3760/cma.j.issn.1673-4114.2017.05.010
[2]	许靖 , 李肖红 , 秦永德 , 张奇洲 , 李毓斌 , 刘立水 , 谢彬 . 帕金森病脑部葡萄糖代谢和脑多巴胺转运体PET显像特点的临床研究. 国际放射医学核医学杂志, 2016, 40(5): 338-344. doi: 10.3760/cma.j.issn.1673-4114.2016.05.003
[3]	原凌 , 刘建中 , 武志芳 . SPECT脑血流灌注显像和受体显像对抑郁症的研究. 国际放射医学核医学杂志, 2007, 31(5): 277-280.
[4]	王津晗 , 徐畅 , 王彦 , 刘强 . 放射性肠损伤模型及其评价研究进展. 国际放射医学核医学杂志, 2017, 41(1): 33-39,44. doi: 10.3760/cma.j.issn.1673-4114.2017.01.007
[5]	潘懿范 , 宋少莉 , 黄钢 . 比较SPECT-CT和PET-CT在小动物模型中的应用. 国际放射医学核医学杂志, 2009, 33(4): 196-199. doi: 10.3760/cma.j.issn.1673-4114.2009.04.002
[6]	夏俊勇 , 王火强 . 以血管内皮生长因子及其受体为靶向的肺癌放射性核素显像. 国际放射医学核医学杂志, 2008, 32(2): 82-85.
[7]	陈素芸 . 放射性核素标记RGD多肽在整合素受体显像中的应用. 国际放射医学核医学杂志, 2007, 31(3): 129-132.
[8]	王培 , 王帅亮 , 朱华 , 杨志 . 放射性核素探针在嵌合抗原受体T细胞治疗显像中的应用. 国际放射医学核医学杂志, 2023, 47(5): 302-307. doi: 10.3760/cma.j.cn121381-202206010-00290
[9]	宁艳丽 , 晋建华 . 癫痫脑内相关受体改变及其PET研究. 国际放射医学核医学杂志, 2009, 33(2): 65-67. doi: 10.3760/cma.j.issn.1673-4114.2009.02.001
[10]	刘晓飞 , 张锦明 , 王洁磊 , 田嘉禾 . 放射性核素标记RGD序列多肽与整合素α_vβ₃受体显像的研究进展. 国际放射医学核医学杂志, 2008, 32(1): 12-15.