多肽受体靶向放射治疗:现状与进展

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多肽受体靶向放射治疗:现状与进展

  • 中图分类号: R817.5

Peptide receptor radionuclide therapy: current status and future directions

  • CLC number: R817.5

  • 摘要: 临床前及临床多中心试验结果已证实应用放射性核素标记的生长抑素类似物进行多肽受体靶向放射治疗(PRRT)的有效性,不同治疗手段联合治疗能进一步提高PRRT的临床疗效,177Lu与90Y标记的生长抑素类似物联合治疗可以获得更好的疗效,其受体在前列腺与乳腺癌等常见肿瘤细胞上表达的蛙皮素和神经肽Y类似物正在研究中。联合放射性核素标记的蛙皮素和神经肽Y类似物进行多受体肿瘤靶向治疗对于乳腺癌及其淋巴结转移灶的诊断与PRRT也很有希望。
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  • 收稿日期:  2005-01-31

多肽受体靶向放射治疗:现状与进展

  • 200233 上海, 上海交通大学附属第六人民医院核医学科

摘要: 临床前及临床多中心试验结果已证实应用放射性核素标记的生长抑素类似物进行多肽受体靶向放射治疗(PRRT)的有效性,不同治疗手段联合治疗能进一步提高PRRT的临床疗效,177Lu与90Y标记的生长抑素类似物联合治疗可以获得更好的疗效,其受体在前列腺与乳腺癌等常见肿瘤细胞上表达的蛙皮素和神经肽Y类似物正在研究中。联合放射性核素标记的蛙皮素和神经肽Y类似物进行多受体肿瘤靶向治疗对于乳腺癌及其淋巴结转移灶的诊断与PRRT也很有希望。

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