辐射诱导的适应性效应及其分子机制

袁德晓; 潘燕; 沈波; 邵春林

辐射诱导的适应性效应及其分子机制

袁德晓 , 潘燕 , 沈波 , 邵春林

文章导航 > 国际放射医学核医学杂志 > 2007, 31 > 5: (296-299)

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辐射诱导的适应性效应及其分子机制

200032 上海, 复旦大学放射医学研究所第三研究室
基金项目:
上海市浦江人才计划(06PJ14012)

国家自然科学基金资助项目(30670629)

教育部新世纪优秀人才支持计划(NCET-06-0365)
中图分类号: Q691.5;R811.5

Radioadaptive response and its molecular mechanism

The Third Department, Institute of Radiation Medicine, Fudan University, Shanghai 200032, China
CLC number: Q691.5;R811.5

摘要: 辐射适应性效应是一种生物防御机制,是指低剂量辐射可以增强细胞对随后高剂量照射的抵抗能力,从而降低高辐射引起的各种损伤.目前为止,RAR的分子机制还不清楚,研究主要涉及DNA损伤修复、细胞周期调控、细胞对抗氧化应激系统以及应激反应蛋白,参与细胞信号传递的分子主要包括蛋白激酶C、有丝分裂原激活蛋白激酶、p53蛋白、共济失调性毛细血管扩张突变基因及DNA依赖性蛋白激酶.
- 辐射效应 /
- 低剂量辐射 /
- 信号转导
Abstract: Radioadaptive response is a biological defense of which low dose ionizing radiation induces cellular resistance to the genotoxic effects of subsequent challenge irradiation. However, so for molecular mechanism of radioadaptive response remains obscure. Research is mainly involved in activation of the intracellular repair system, cell cycle regulation system, antioxidative stress system and stress-response protein. Signaling factors involved in cell response to radiation include protein kinase C, mitogen-activated protein kinase, p53 tumor suppressor protein, ataxia-telansiectasia mutated, and DNA-dependent protein kinase.
- Radioation effact /
- Low dose radiation /
- Signaling transduction
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[1]	Tapio S, Jacob V. Radioadaptive response revisited. Radiat Environ Biophys, 2007, 46(1):1-12.
[2]	Miura Y, Abe K, Urano S, et al. Adaptive response and the influence of ageing:effects of low-dose irradiation on cell grouch of cultured glial cells. Int J Radiat Biol,2002, 78(10):913-921.
[3]	Correa CR, Cheung VG. Genetic variation in radiation-induced expression phenotypes. Am J Hum Genet, 2004, 75(5):885-890.
[4]	Raaphorst GP, Li LF, Yang DP. Evaluation of adaptive responses to cisplatin in normal and mutant cell lines with mutations in recombination repair pathways. Anticancer Res, 2006, 26(2A):1183-1187.
[5]	Seo HR, Chung HY, Lee YJ, et al. p27Cip/Kip is involved in hsp25 or inducible hsp70 mediated adaptive respunse by low dose radiation. J Radiat Res,2006,47(1):83-90.
[6]	Zhou PK, Rigaud O. Down-regulation of the human CDC16 gene after exposure to ionizing radiation:a possible role in the radioadaptive response. Radiat Res, 2001, 155(1):43-49.
[7]	Otsuka K, Koana T. Activation of antioxidative enzymes induced by low-dose-rate whole-body gamma irradiation:adaptive response in terms of initial DNA damage. Radiat Res, 2006, 166(3):474-478.
[8]	Szumiel I. Adaptive response:stimulated DNA response or decreased damage fixation?.Int J Radiat Biol, 2005, 81(3):233-241.
[9]	Lehnert BE, Lyer R. Exposure to low-level chemicals and ionizing radiation:reactive oxygen species and cellular pathway. Hum Exp Toxicol, 2002, 21(2):65-69.
[10]	de Toledo SM, Asaad N, Venkataehalam P, et al. Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts:the role of growth architecture and oxidative metabolism. Radiat Res, 2006, 166(6):849-857.
[11]	Kang CM,Park KP, Cho CK, et al. Hspa4(HSP70) is involved in the radioadaptive response:result from mouse splenocytes. Radiat Res, 2002, 157(6):650-655.
[12]	Carette J, Lehnert S, Chow TY. Implication of PBP74/mortalin/GRP75 in the radio-adaptive response. Int J Radiat Biol, 2002, 78(3):183-190.
[13]	Park SH, Lee SJ, Chung HY, et al. Inducible heat-shock protein 70 is involved in the radioadaptive response. Radiat Res, 2000, 153(3):318-326.
[14]	Sasaki MS, Ejima Y, Tachibana A, et al. DNA damage response pathway in radioadaptive response. Mutat Res, 2002, 504(1-2):101-118.
[15]	Gopalakrishna R, Jaken S. Protein kinase C signaling and oxidative stress. Free Radical Med. 2000, 28(9):1349-1361.
[16]	Okazaki R, Ootsuyama A, Norimura T. TP53 and TP53-related genes associated with protection from apoptosis in the radioadaptive response. Radiat Res, 2007, 167(1):51-57.
[17]	Schwartz JL, Jordan tl, Slovic J, et al. Induction and loss of a TP53-dependent radioadaptive response in the human lymphoblastoid cell model TK6 and its abrogation by BCL2 over-expression. Int J Radiat Biol, 2007, 83(3):153-159.
[18]	She QB, Chert N, Dong Z. ERKs and p38 kinase phosphorylate p53 at serine 15 in response to UV radiation. J Biol Chem, 2000, 275(27):20444-20449.
[19]	Andrysik Z, Machala M, Chramostova K, et al. Activation of ERK1/2 and p38 kinases hy polycyclic alvmatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis. Toxicol Appl Pharmacol, 2006, 211(3):198-208.
[20]	Reinhardt HC, Aslanian AS, Lees JA, et al. p53-deficient cells rely on ATM-and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell, 2007, 11(2):175-189.

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[7]	苏燎原 . 第二届《低和很低剂量电离辐射对人体健康效应》国际学术交流会议简介. 国际放射医学核医学杂志, 2001, 25(6): 265-271.
[8]	周平坤 , 夏寿萱 . 真核基因损伤修复和基因表达的辐射兴奋效应. 国际放射医学核医学杂志, 1996, 20(5): 223-226.
[9]	周继文 , 卢正福 . 胎内照射的辐射效应. 国际放射医学核医学杂志, 1995, 19(1): 25-28.
[10]	王小华 , 余争平 , 程天民 . 角质细胞生长因子及其辐射防护作用. 国际放射医学核医学杂志, 1999, 23(5): 233-235.

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辐射诱导的适应性效应及其分子机制

200032 上海, 复旦大学放射医学研究所第三研究室

收稿日期: 2007-05-24

基金项目: 上海市浦江人才计划(06PJ14012)国家自然科学基金资助项目(30670629)教育部新世纪优秀人才支持计划(NCET-06-0365)

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摘要: 辐射适应性效应是一种生物防御机制,是指低剂量辐射可以增强细胞对随后高剂量照射的抵抗能力,从而降低高辐射引起的各种损伤.目前为止,RAR的分子机制还不清楚,研究主要涉及DNA损伤修复、细胞周期调控、细胞对抗氧化应激系统以及应激反应蛋白,参与细胞信号传递的分子主要包括蛋白激酶C、有丝分裂原激活蛋白激酶、p53蛋白、共济失调性毛细血管扩张突变基因及DNA依赖性蛋白激酶.