单纯疱疹病毒1-胸苷激酶报告基因显像研究进展

刘影; 兰晓莉; 张永学

刘影 , 兰晓莉 , 张永学

文章导航 > 国际放射医学核医学杂志 > 2007, 31 > 6: (329-333)

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单纯疱疹病毒1-胸苷激酶报告基因显像研究进展

430022 武汉, 华中科技大学协和医院核医学科、湖北省分子影像重点实验室

通讯作者: 张永学, zhyxl229@163.com

基金项目:
国家自然科学基金资助项目(30571816,30400176)
中图分类号: R817.4

Advances in study of perpes simplex virus type 1-thymidine kinase reporter gene imaging

Department of Nuclear Medicine, Union Hospital, Huazhong University of Science and Technology;Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China

Corresponding author: ZHA NG Yong-xue, zhyxl229@163.com

CLC number: R817.4

摘要: 放射性核素报告基因显像技术作为监测基因治疗表达的一种有效手段,是目前研究的热点。报告基因系统主要有三类,其中酶的报告基因系统中的单纯疱疹病毒1-胸苷激酶由于其良好的理化特性,适合作为报告基因而对其进行了深入、广泛的研究,它的两类底物是嘌呤核苷衍生物和无环鸟苷衍生物,目前已经用不同放射性核素进行标记而达到显像目的。
- 基因,报告 /
- 单纯疱疹病毒1-胸苷激酶 /
- 放射性核素显像
Abstract: Radionuclide reporter gene imaging is an effect way to provide qualitative and quantitative information for gene therapy. There are three systems of reporter gcne including kinase reporter gene. perpes simplex virus type 1-thymidine kinase (HSV1-tk) has perfect physical and chemical characteristic which is suit for imaging as reporter gene. It has been widely investigated and intensively researched. Two substrates of HSV1-tk are purine nucleosite derivant and acyclovir derivant, which can also be used as reporter probes of HSV1-tk.
- Gene,reporter /
- Perpes simplex virus type 1-thymidine kinase /
- Radiation nuclide imaging
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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单纯疱疹病毒1-胸苷激酶报告基因显像研究进展

通讯作者: 张永学, zhyxl229@163.com

430022 武汉, 华中科技大学协和医院核医学科、湖北省分子影像重点实验室

收稿日期: 2007-01-25

基金项目: 国家自然科学基金资助项目(30571816,30400176)

关键词:

摘要: 放射性核素报告基因显像技术作为监测基因治疗表达的一种有效手段,是目前研究的热点。报告基因系统主要有三类,其中酶的报告基因系统中的单纯疱疹病毒1-胸苷激酶由于其良好的理化特性,适合作为报告基因而对其进行了深入、广泛的研究,它的两类底物是嘌呤核苷衍生物和无环鸟苷衍生物,目前已经用不同放射性核素进行标记而达到显像目的。