单链抗体研究进展及其在医学中的应用

秦丽莉; 张春明

单链抗体研究进展及其在医学中的应用

秦丽莉 , 张春明

文章导航 > 国际放射医学核医学杂志 > 2005, 29 > 6: (255-257)

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单链抗体研究进展及其在医学中的应用

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
基金项目:
天津市科技攻关培育项目资助(043102211)
中图分类号: Q511

The research progress and medicine application of the ScFv antibody

Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
CLC number: Q511

摘要: 自英国和日本学者发现白喉抗毒素以来,人们对于抗体的研究经历了多克隆抗体、单克隆抗体和基因工程抗体3个阶段,其中单链抗体由于具有相对分子质量小、穿透力强、血中半衰期短、抗原结合特异性强、免疫原性弱和可在原核细胞中表达等特点而倍受人们关注。
- 单链抗体 /
- 免疫显像诊断 /
- 靶向治疗
Abstract: Since the scholar of England and Japan had found the diphtheria antitoxin, the research of the antibody has experienced three phases:polyclonal antibodies, monoclonal antibodies and genetically engineered antibodies. In recent years, far more attention has been paid to single-chain antibody by researchers owing to it's small molecular, strong ability of penetration, short half-lives in blood, high specificity to combine with the corresponding antibody, weak immunogenicity and possibility to be expressed in prokaryocyte.
- single-chain antibody /
- immunoimage diagnose /
- targeted therapy
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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