酸性神经鞘磷脂酶的生物学特性及其功能

侯丽莉; 陈肖华

酸性神经鞘磷脂酶的生物学特性及其功能

侯丽莉 , 陈肖华

文章导航 > 国际放射医学核医学杂志 > 2005, 29 > 1: (44-47)

引用本文:

Citation:

酸性神经鞘磷脂酶的生物学特性及其功能

100850 北京, 军事医学科学院放射医学研究所
中图分类号: Q345⁺.2

Property and function of acid sphingomyelinase

Institute of Radiation Medicine, Academy of Military Science, Beijing, 100850, China
CLC number: Q345⁺.2

摘要: 神经鞘磷脂酶(SMase)可水解鞘磷脂产生神经酰胺,在人体内发挥重要作用。酸性神经鞘磷脂酶(ASMase)作为SMase最重要的一个亚型,在辐射诱导细胞凋亡、调节肿瘤细胞生长、参与Fas信号系统传递等方面均可发挥重要作用。
- 神经鞘磷脂酶 /
- 酸性神经鞘磷脂酶 /
- 神经酰胺 /
- 凋亡
Abstract: Sphingomyelinase can hydrolyze the sphingomyelin to ceramide. And sphingomyelinase play important roles in diverse physiological. Acid sphingomyelinase is the most important type of sphin-gomyelinase.
- sphingomyelinase /
- acid sphingomyelinase /
- ceramide /
- apoptosis
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Marathe S, Miranda SR, Tabas I, et al. Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase:relationship between brain intra-lysesomal enzyme activity and central nervous system function[J]. Hum Mol Genet,2000, 9(13):1967-1976.
[2]	Goni FM, Alonso A. Sphingomyelinases:enzymology and membrane activity[Jl. FEBS Letter, 2002, 531(1):38-46.
[3]	Murate T, Susuki M, Hattori M, er al. Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line[J]. J Biol Chem, 2002, 277(12):9936-9943.
[4]	Testai FD, Landek, Goswami R. Acid sphingomyelinase and inhibition by phosphate ion:role of inhibition by phosphafidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling[J]. J Neurochem,2004, 89(3):636-644.
[5]	Garcia-Barros M, Paris F, Cordon-Cardo C, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis[J]. Science, 2003,300(5622):1155-1159.
[6]	Watters D. Molecular mechanisma of ionizing radiation induced apoptosis[J]. Immunol Cell Biol, 77(3):263-271.
[7]	Haimovitz-Friedman A, Karl CC, Ehleiter D, et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis[J]. J Exp Med, 1994, 180(2):525-535.
[8]	Vit JP, Rosselli F. Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis[J]. Oncogene, 2003, 22(54):8645-8652.
[9]	Bird GL, Sheron N, Goka AK, et al. Increased plasma tumor necrosis factor in severe alcoholic hepatitis[J]. Ann Intern Med, 1990, 112(12):917-920.
[10]	Mato JM, Alvarez L, Ortiz P, et al. S-adenosylmethionine synthesis:molecular mechanisms and clinical implications[J]. Pharmacol Ther,1997, 73(3):265-280.
[11]	Kolesnick RN, Kronke M. Regulation of ceramide production and auoptosis[J]. Ann Rev Physiol, 1998, 60:643-665.
[12]	Garcia-Ruiz C, Mari M, Morales A, et al. Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase,induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes[J]. Hepatology, 2000, 32(1):56-65.
[13]	Mari M, Colell A, Morales A, et al. Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A,contributing to tumor necrosis factor-induced lethal hepatitis[J]. J Clin Invest, 2004, 113(6):895-904.
[14]	Lin T, Genestier L, Pinkosk M J, et al. Role of acidic sphingomyelinase in Fas/CD95-mediated cell death[J]. J Biol Chem, 2000, 275(12):8657-8663.
[15]	Paris F, Grassme H, Cremesti A, et al. Natural ceramide reverses fas resistance of acid sphingomyelinase h^-/-epatocytes[J]. J Biol Chem,2001,276(11):8297-8305.
[16]	Utermohlen O, Karow U, Lohler J, et al. Severe impairment in early host defense against listeria monocytogenes in mice deficient in acid sphingomyelinase[J]. J Immunol, 2003, 170(5):2621-2628.

[1]	李林 , 史剑慧 . 神经酰胺与辐射诱导细胞凋亡. 国际放射医学核医学杂志, 2000, 24(2): 85-89.
[2]	龚守良 , 刘树铮 . 生精细胞凋亡与电离辐射. 国际放射医学核医学杂志, 1999, 23(5): 227-230.
[3]	古桂雄 . 辐射诱导发育脑细胞凋亡的分子调节. 国际放射医学核医学杂志, 2000, 24(2): 82-85.
[4]	司宏伟 , 李险峰 . ¹³¹I对甲状腺细胞凋亡的影响. 国际放射医学核医学杂志, 2003, 27(2): 94-96.
[5]	段炼 , 李险峰 . 凋亡心肌核素显像的研究进展. 国际放射医学核医学杂志, 2004, 28(1): 9-11.
[6]	张春智 . 放射治疗诱导肿瘤细胞凋亡的近期研究动态. 国际放射医学核医学杂志, 2004, 28(6): 281-283.
[7]	刘发全 . 辐射损伤与修复的研究近况. 国际放射医学核医学杂志, 2000, 24(4): 186-188.
[8]	王济东 , 王俊杰 . 低剂量率辐射生物效应的研究进展. 国际放射医学核医学杂志, 2005, 29(4): 186-189.
[9]	高炎 , 刘志成 , 闵长庚 . 肺癌患者血清神经原特异烯醇化酶值的临床研究. 国际放射医学核医学杂志, 1988, 12(1): 60-61.
[10]	赵德明 , 洪元康 . 放射导致臂丛神经损伤. 国际放射医学核医学杂志, 1993, 17(6): 257-258.