18F-氟脱氧葡萄糖PET-CT与99nTc-亚甲基二膦酸盐骨显像诊断转移性骨肿瘤的对比研究
Comparison study of 18F-fluorodeoxyglucose PET-CT and 99Tc-methylene phospho-nate bone scan in detecting bone metastases
-
摘要: 目的 探讨18F-氟脱氧葡萄糖(18F-FDG) PET-CT与唧99mTc-亚甲基二膦酸盐(99mTc-MDP)全身骨显像对转移性骨肿瘤的诊断价值。方法 93例经病理证实为恶性肿瘤的患者同时接受18F-FDG PET-CT和99mTc-MDP全身骨显像(时间间隔在1周之内),对比分析两种显像结果,骨转移的诊断通过随访2年,由病理、X射线片、CT或MRI检查结果综合决定。结果 93例恶性肿瘤患者中,经过2年随访或病理证实骨转移44例,其中18F-FDG PET-CT灵敏度、特异度和准确率分别为95.4%、91.8%和93.5%,99mTc-MDP全身骨显像分别为90.9%、63.3%和76.3%。18F-FDG PET-CT对转移性骨肿瘤诊断的灵敏度与99mTc-MDP全身骨显像相近,但特异度(t=2.53,P<0.05)和准确率t=2.47,P<0.05)均明显高于99mTc-MDP全身骨显像。结论 PET-CT对转移性骨肿瘤有较高的诊断价值。
-
关键词:
- 骨肿瘤 /
- 肿瘤转移 /
- 氟脱氧葡萄糖F18 /
- 99mTc-美罗酸盐 /
- 体层摄影术,X线计算机 /
- 体层摄影术,发射型计算机 /
- 对比研究
Abstract: Objective To investigate the diagnostic value of 18F-fluorodcoxyglucose PET-CT and 99mTc-methylene phosphonate whole body imaging in detection bone metastases.Methods 18F-FDG PET-CT and 99mTc-MDP whole body bone scan were both performed in 93 patients with malignant tumors testified by pathology.Bone metastases were confirmed by pathology,X ray or CT or MRI and follow-up for not less than 2 years.Results Of the 93 patients 44 were confirmed to have bone metastases by 2 years follow-up or pathology.The sensitivity,specificity and accuracy of 18F-FDG PET-CT were 95.4%,91.8%,93.5%,and 99mTc-MDP bone imaging were 90.9%,63.3%,76.3%,respectively.18F-FDG PET-CT has a better specificity (t=2.53,P<0.05)and accuracy (t=2.47,P<0.05)in detecting bone metastases than that of 99mTc-MDP bone imaging.Conclusion PET-CT is a more valuable method in the diagnosis of bone metastases. -
[1] 孙达.放射性核素骨显像[M].杭州:浙江大学出版社,2000.32.
[2] 丁勇,田嘉禾,候亚彬,等. 18FDG-PET和99Tc-MDP骨扫描检测骨转移瘤价值的比较[J].中国医学影像学杂志,2004,12(3):174-176.
[3] Gallowitsch HJ, Kresnik E, Gasser J, et al. F-18 fluorodeoxy glucose positron-emission tomography in the diagnosis of tumor recurrenceand metastases in the follow-up of patients with breast carcinoma:A comparison to conventional imaging[J]. Invest Radiol, 2003, 38(5):250-256. [4] Yang SN, Liang JA, Lin FJ, et al. Comparion whole body 18F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer[J]. J Cancer Res Clin Oncol, 2002, 128(6):325-328. [5] Metser U, Lerman H, Blank A, et al. Malignant involvement of the spine:assessment by 18F-FDG PET-CT[J]. J Nucl Med, 2004, 45(2):279-284. [6] 姚稚明. 18F-FDG PET/CT鉴别诊断椎骨良恶性病变的临床价值[J].诊断学理论与实践,2005,4(2):164-167.
-
点击查看大图
计量
- 文章访问数: 1465
- HTML全文浏览量: 149
- PDF下载量: 2
下载: