电离辐射诱导G<sub>2</sub>期阻滞的机制

苑晓燕

电离辐射诱导G₂期阻滞的机制

苑晓燕

文章导航 > 国际放射医学核医学杂志 > 2002, 26 > 6: (278-280,284)

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电离辐射诱导G₂期阻滞的机制

苑晓燕

400038 重庆, 第三军医大学防原医学教研室

作者简介: 苑晓燕(1977-),女,河南鲁山人,硕士研究生,主要从事放射生物学研究。;

中图分类号: Q253;Q691.9

Mechanisms of ionizing radiation-induced G₂ arrest

YUAN Xiao-yan

Department of Radiation Medicine, Third Military Medical University, Chongqing 400038, China
CLC number: Q253;Q691.9

摘要: 电离辐射损伤后,细胞通过若干关卡来调控细胞周期的进程,使细胞有时间进行DNA修复,确保染色体组的完整性和遗传稳定性,减少突变的发生。不同的电离辐射使不同细胞产生G₁、G₂和S期等不同时相的变化,但电离辐射后G₂期阻滞的现象十分普遍。近年来,对G₂期阻滞机制的研究多集中在Chk1、Chk2和p53上。
- 电离辐射 /
- G₂期阻滞 /
- Chk1 /
- Chk2 /
- p53
Abstract: Cells regulate cell cycle progression by arresting several checkpoints in response to ionizing radiation,which provides time for them to repair DNA damage,ensures genomic integrity and genetic stability and in turn decreases genetic mutations.Different cells arrest different checkpoints such as G₁-,G₂- and S-phase checkpoint in response to different ionizing radiations,whereas G₂-phase arrest is more prevalent.More attention has been focused on Chk1,Chk2and p53in the study of mechanisms of ionizing-radiation-induced G₂ arrest these years.
- ionizing radiation /
- G₂ arrest /
- Chkl /
- Chk2 /
- p53
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[1]	刘光伟 , 龚守良 . 电离辐射诱导的细胞G₂期阻滞. 国际放射医学核医学杂志, 2002, 26(4): 180-182.
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[3]	傅海青 , 鞠桂芝 . p53基因状态与辐射诱导的G₁期阻滞. 国际放射医学核医学杂志, 1997, 21(3): 133-137.
[4]	于文儒 , 董连锴 , 萧佩新 . 辐射敏感性与p53基因突变关系的研究进展. 国际放射医学核医学杂志, 1996, 20(5): 233-235.
[5]	由莉 , 赵永成 . γ-H2AX分析及其在监测电离辐射所致DNA双链断裂中的应用前景. 国际放射医学核医学杂志, 2006, 30(1): 50-52.
[6]	徐畅 , 王彦 , 杜利清 , 曹嘉 , 刘强 . shRNA干扰沉默Net1基因对电离辐射损伤反应的影响. 国际放射医学核医学杂志, 2013, 37(3): 135-138. doi: 10.3760/cma.j.issn.1673-4114.2013.03.002
[7]	王仲文 . 电离辐射诱发的基因组不稳定性与辐射致癌. 国际放射医学核医学杂志, 2000, 24(5): 226-230.
[8]	贾卫华 , 王继先 , 陶祖范 . 电离辐射与乳腺癌. 国际放射医学核医学杂志, 1995, 19(3): 137-140.
[9]	傅尚志 , 张楚毅 , 张景源 . 电离辐射对肝脏的损伤. 国际放射医学核医学杂志, 1997, 21(4): 188-191.
[10]	刘建军 , 汪涛 . 大脑发育和电离辐射. 国际放射医学核医学杂志, 1999, 23(2): 82-85.

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电离辐射诱导G₂期阻滞的机制

苑晓燕

作者简介:苑晓燕(1977-),女,河南鲁山人,硕士研究生,主要从事放射生物学研究。

400038 重庆, 第三军医大学防原医学教研室

收稿日期: 2002-07-12

关键词:

电离辐射 /
G₂期阻滞 /
Chk1 /
Chk2 /
p53

摘要: 电离辐射损伤后,细胞通过若干关卡来调控细胞周期的进程,使细胞有时间进行DNA修复,确保染色体组的完整性和遗传稳定性,减少突变的发生。不同的电离辐射使不同细胞产生G₁、G₂和S期等不同时相的变化,但电离辐射后G₂期阻滞的现象十分普遍。近年来,对G₂期阻滞机制的研究多集中在Chk1、Chk2和p53上。