恶性骨肿瘤多药耐药的99Tcm-MIBI体层显像研究
Research of 99Tcm-MIBI SPECT imaging for assessment of multidrug resistance in Bone tumor
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摘要: 大多数肿瘤都有多药耐药-1(MDR-1)基因的过度表达,其表达产物P-糖蛋白(P-gp)在肿瘤的耐药机制中起着关键作用,对P-gp表达的预测在化疗中至关重要,99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)转运分析可作为探测低水平的P-gp表达和定量评价调节转运的敏感指标,指导应用调节剂改善化疗效果。
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关键词:
- 骨肿瘤 /
- 单光子,发射型计算机,体层摄影术 /
- 多药耐药 /
- 99Tcm-甲氧基异丁基异腈
Abstract: There has a overexpression ofmultidrug resistance (MDR) gene in most tumor. It is very important that it's expression product P-glycoprotein(P-gp)in multidrug resistance machine of tumor. The anticipation for P-gp expression is significance for chemotherapy. The conveying analysis of 99Tcm-sestamibi (99Tcm-MIBI) is a sensitiveness index for low-level P-gp expression. -
[1] 周际昌.实用肿瘤内科学[M].北京:人民卫生出版社,2003.85.
[2] Baldini N, Scotland K, Scrra M, et al. Adria mycin binding assay;avaluable chemosensitivety test in human ostesarcoma[J]. J Cancer Res Clin Oncol, 1992, 119(1):121-126. [3] Burak Z, Ersoy O, Moretti J, et al. The role of 99mTc-MIBI scintigraphy in the assessment of MDR1 overexpression in patients with musculoskeletal sarcomas:comparison with therapy response[J]. Eur J Nucl Med, 2001, 28(9):1341-1350. [4] Junichi T, Hisashi S, Naohiro A, et al. Assessment of P-glycoprotein in patients with malignant bone and soft-tissue tumors using technetium-99m-MIBI scintigraphy[J]. J Nucl Med, 1998, 39(10):1179-1184. [5] Burak Z, Moretti JL, Ersoy O, et al.99mTc-MIBI imaging as a predictor of therapy response in osteosarcoma compared with multidrug resistance-associated protein and P-glycoprotein exprenssion[J]. J Nucl Med, 2003, 44(9):1394-1401. -
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