放射性核素标记小分子多肽治疗肿瘤的研究进展

周玉凤

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放射性核素标记小分子多肽治疗肿瘤的研究进展

  • 中图分类号: R817.5

The recent development of receptor targeting therapy for tumors with radiopeptides

  • CLC number: R817.5

  • 摘要: 近年来,应用放射性核素标记多肽进行受体靶向治疗在肿瘤治疗领域已变得非常重要。临床应用最多的是生长抑素类似物。现已成功开发出放射性核素标记的α-黑色素细胞刺激激素、神经紧张素、血管活性肠肽、铃蟾肽、P物质、神经肽Y、缩胆囊素类似物等,并已进行体内、外研究。综述了应用90Y和177Lu标记的生长抑素类似物进行受体介导放射性核素靶向治疗的情况,以及放射性核素标记的缩胆囊素和神经肽Y用于内照射治疗的前期临床资料。
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  • [1] 罗全勇 . 多肽受体靶向放射治疗:现状与进展. 国际放射医学核医学杂志, 2005, 29(2): 74-78.
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    [3] 马寄晓叶大铸 . 奥曲肽及其类似物用于肿瘤治疗的进展. 国际放射医学核医学杂志, 2005, 29(2): 79-84.
    [4] 叶大铸马寄晓 . 奥曲肽及其类似物用于肿瘤诊断的进展. 国际放射医学核医学杂志, 2003, 27(3): 97-100.
    [5] 章斌188Re直接标记octreotide的方法学. 国际放射医学核医学杂志, 2002, 26(5): 220-222.
    [6] 杨永青 . 标记免疫分析在心血管疾病中的临床价值及其进展. 国际放射医学核医学杂志, 2000, 24(5): 193-196.
    [7] 王晓青谢毓元 . 以多肽导向的靶向造影剂的研究. 国际放射医学核医学杂志, 1996, 20(2): 49-53.
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  • 收稿日期:  2004-08-19

放射性核素标记小分子多肽治疗肿瘤的研究进展

  • 226361 南通, 江苏省南通市肿瘤医院核医学科

摘要: 近年来,应用放射性核素标记多肽进行受体靶向治疗在肿瘤治疗领域已变得非常重要。临床应用最多的是生长抑素类似物。现已成功开发出放射性核素标记的α-黑色素细胞刺激激素、神经紧张素、血管活性肠肽、铃蟾肽、P物质、神经肽Y、缩胆囊素类似物等,并已进行体内、外研究。综述了应用90Y和177Lu标记的生长抑素类似物进行受体介导放射性核素靶向治疗的情况,以及放射性核素标记的缩胆囊素和神经肽Y用于内照射治疗的前期临床资料。

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