血浆脑利钠肽在快速鉴别诊断心源性和肺源性呼吸困难中的价值

瞿跃进; 俞浩; 陈贵兵; 方亚; 黄劲雄; 何小江

瞿跃进 , 俞浩 , 陈贵兵 , 方亚 , 黄劲雄 , 何小江

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 4: (218-220)

引用本文:

Citation:

血浆脑利钠肽在快速鉴别诊断心源性和肺源性呼吸困难中的价值

1. 361003 厦门, 厦门市第一医院呼吸内科;
2. 361003 厦门, 厦门市第一医院核医学科;
3. 361003 厦门, 厦门大学侠学院预防医学系

通讯作者: 俞浩, yuha060@gmail.com ;

Value of plasma brain natriuretie peptide for differentiating cardiogenic dyspnea from pulmogenic dyspnea

1. Department of Respiratory Medicine, Fujian Medical University, Xianmen, Fujian 361003, China;
2. Department of Nuclear Medicine, FiLet Hospital of Xiamen, Fujian Medical University, Xianmen, Fujian 361003, China;
3. Department of Phylaxiology, Medical college of Xiamen University, Xiamen, Fujian 361003, China

Corresponding author: YU Hao, yuha060@gmail.com ;

摘要: 目的评价血浆脑利钠肽(BNP)水平在心源性和肺源性呼吸困难时鉴别诊断的价值。方法采用美国拜尔公司生产的化学发光检测仪及其BNP试剂,检测248例因呼吸困难住院的肺疾病患者血浆BNP水平,对单纯肺疾病患者、肺疾病并发左心功能不全患者、肺疾病未并发左心功能不伞患者、肺疾病并发右心衰患者各组间BNP水平进行比较。结果肺疾病并发左心功能不全的呼吸困难患者的BNP水平明显高于未并发左心功能不全的呼吸困难患者(χ²=25.597,P<0.001);肺疾病并发右心衰患者BNP水平高于单纯肺疾病患者,但差异没有统计学意义(t=1.614,P>0.05);肺疾病并发左心功能不全患者的BNP水平明显高于肺疾病并发右心衰患者(t=2.531,P<0.05);肺疾病并发左心功能不全患者的心功能越差,BNP水平就越高,心功能Ⅱ、Ⅲ、Ⅳ级三组间BNP水平的差别有统计学意义(χ²=29.463,P<0.001)。结论血浆BNP是快速鉴别诊断心源性和肺源性呼吸困难的莺要实验室检测指标,同时可判断肺疾病并发左心功能不全患者心衰的严重程度。
- 呼吸困难 /
- 利钠肽,脑 /
- 心室功能障碍,左
Abstract: Objective To evaluate the value of plasma brain natriuretic peptide (BNP) level for differentiating eardiogenie dyspnea from pulmogenic dyspnea.Methods The detection of plasma BNP was carried out in 248 patients with dyspnea.The apparatus was the CENTUR type chemiluminescence detection produced by the Bayer companies of USA.All patients were divided into three groups depending on disease severity.The level of plasma BNP in each group wag compared.Results The level of plasma BNP in pulmonary disease complicated with left ventricular dysfunction was higher than that of pulmonary disease non-complicated with left ventricular dysfunction.There was significant difference between two groups (χ²=25.597,P<0.001).The level of plasma BNP in pulmonary disease complicated with right ventricular dysfunction was higher than that of simple pulmonary disease.There was no significant difference between two groups (t=1.614,P>0.05).The level of plasma BNP in pulmonary disease complicated with left ventricular dysfunction was higher than that of pulmonary disease complicated with fight ventricular dysfunction.There Was significant difference between two groups (t=2.53 l,P<0.05).If the left ventricular dysfunction degree was notable,the level of plasma BNP waft,high.There was also significant difference in different cardiac function classification by New York Heart Association (χ²=29.463,P<0.001).Conclusion Plasma BNP analysis is an impotent method for differentiating cardiogenic dyspnea from pulmogenie dyspnea.Meanwhile,it is also helpful to evaluating the severity of pulmonary disease complicated with left ventricular dysfunction.
- Dyspnea /
- Natriuretic peptide,brain /
- Ventricular dysfunction,left
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	陈淑芳,徐卓玉,张婷.脑利尿肽的研究进展[J].齐鲁医学杂志,2005.20(f4):367-370.
[2]	Yasue H,Yoshimura M,SumMa H,et al.Localization and mechanism of secretion of B type natriuretic peptide in comparison with those A type natfiuretie peptide in normal subjects and patients with heart failure[J].Circulation,1994,90(1):195-203.
[3]	Müller C,Kuster G,Büttner HJ,et al.B-type natfiuretic peptidecurrent use in the diagnosis and management of heart failure,[J]. Herz,2003,28(5):374-379.
[4]	Morrison LK,Harrison A,Krishnaswamy P,et al.Utility of a rabid B-type natriuretie peptide assay in differentiating congestive heart failure from lungdisease in patients presenting with dyspnea[J].J Am Coil Cardiol,2002,39(2):202-209.
[5]	羊镇宇,王如兴,李肖蓉,等.B型利钠肽测定对充血性心力衰竭患者预后评估的研究[J].中国心血管杂志,2005,10(3): 201-203.
[6]	卢飞舟,赵殿有.充血性心力衰竭患者血浆脑钠素浓度与心功能的关系[J].心脏杂志,2004,16(3):266-267.
[7]	陶以嘉,李春庆,金伟东,等.血浆B型利钠肽(BNP)在心功能不全巾的诊断和治疗效果中的应用[J].中国微循环.2005, 9(6):433-435.
[8]	Bando M,lshii Y,Sugiyama Y,et al.Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cot pulmonale[J].Respir Med.1999,93(7):507-514.
[9]	何权瀛,马艳良.脑钠肽测定对心源性和肺源性呼吸嗣难的痉别诊断[J].中华结核和呼吸杂志.2007,30(8):610-612.

[1]	于建芳 . 核医学显像评估生殖与性功能障碍. 国际放射医学核医学杂志, 2002, 26(4): 169-172.
[2]	袁瑛 , 顾兆祥 . 放射性核素显像在轻度认知功能障碍中的应用价值. 国际放射医学核医学杂志, 2008, 32(4): 209-213.
[3]	冯苏洋 , 邢炯 , 舒敏 , 刘加成 . 抑郁症相关执行功能障碍的磁共振成像研究进展. 国际放射医学核医学杂志, 2021, 45(12): 795-799. doi: 10.3760/cma.j.cn121381-202012010-00117
[4]	苏应瑞 , 查金顺 , 周竟雄 , 林夏鸿 , 许朝祥 , 王耀国 , 杜心清 . ¹³¹I治疗甲亢性心脏病患者尿脑钠肽水平变化的研究. 国际放射医学核医学杂志, 2012, 36(6): 371-375. doi: 10.3760/cma.j.issn.1673-4114.2012.06.012
[5]	王赞 , 编辑部 . ¹⁸F-DG/²⁰¹Tl SPECT、²⁰¹Tl负荷再注射SPECT及多巴胺超声心动图预测血管重建术后心肌功能障碍恢复的比较. 国际放射医学核医学杂志, 1997, 21(4): 170-170.
[6]	郭雪君 , 朱承谟 . 呼吸道粘液-纤毛清除功能测定. 国际放射医学核医学杂志, 1994, 18(3): 131-134.
[7]	Ell PJ , et al . 脑的功能显像. 国际放射医学核医学杂志, 1988, 12(1): 57-60.
[8]	杜微云 , 杨一峰 , 陈灏珠 , 蒋长英 . 核素心室造影评价左心室舒张功能. 国际放射医学核医学杂志, 1993, 17(6): 269-272.
[9]	岳园芳 , 刘建井 , 尹国涛 , 戴东 , 徐文贵 . DTC患者¹³¹I治疗后左甲状腺素钠片最佳初始剂量预测模型探究. 国际放射医学核医学杂志, 2022, 46(4): 197-202. doi: 10.3760/cma.j.cn121381-202111005-00171
[10]	张金谷 . 儿童时期行为障碍的SPECT脑血流显像改变. 国际放射医学核医学杂志, 1995, 19(3): 110-114.

点击查看大图

计量

文章访问数: 1448
HTML全文浏览量: 93
PDF下载量: 2

血浆脑利钠肽在快速鉴别诊断心源性和肺源性呼吸困难中的价值

通讯作者: 俞浩, yuha060@gmail.com;

1. 361003 厦门, 厦门市第一医院呼吸内科;
2. 361003 厦门, 厦门市第一医院核医学科;
3. 361003 厦门, 厦门大学侠学院预防医学系

收稿日期: 2008-04-01

关键词:

摘要: 目的评价血浆脑利钠肽(BNP)水平在心源性和肺源性呼吸困难时鉴别诊断的价值。方法采用美国拜尔公司生产的化学发光检测仪及其BNP试剂,检测248例因呼吸困难住院的肺疾病患者血浆BNP水平,对单纯肺疾病患者、肺疾病并发左心功能不全患者、肺疾病未并发左心功能不伞患者、肺疾病并发右心衰患者各组间BNP水平进行比较。结果肺疾病并发左心功能不全的呼吸困难患者的BNP水平明显高于未并发左心功能不全的呼吸困难患者(χ²=25.597,P<0.001);肺疾病并发右心衰患者BNP水平高于单纯肺疾病患者,但差异没有统计学意义(t=1.614,P>0.05);肺疾病并发左心功能不全患者的BNP水平明显高于肺疾病并发右心衰患者(t=2.531,P<0.05);肺疾病并发左心功能不全患者的心功能越差,BNP水平就越高,心功能Ⅱ、Ⅲ、Ⅳ级三组间BNP水平的差别有统计学意义(χ²=29.463,P<0.001)。结论血浆BNP是快速鉴别诊断心源性和肺源性呼吸困难的莺要实验室检测指标,同时可判断肺疾病并发左心功能不全患者心衰的严重程度。

English Abstract

Value of plasma brain natriuretie peptide for differentiating cardiogenic dyspnea from pulmogenic dyspnea

Corresponding author: YU Hao, yuha060@gmail.com

1. Department of Respiratory Medicine, Fujian Medical University, Xianmen, Fujian 361003, China;
2. Department of Nuclear Medicine, FiLet Hospital of Xiamen, Fujian Medical University, Xianmen, Fujian 361003, China;
3. Department of Phylaxiology, Medical college of Xiamen University, Xiamen, Fujian 361003, China

Received Date: 2008-04-01

Abstract: Objective To evaluate the value of plasma brain natriuretic peptide (BNP) level for differentiating eardiogenie dyspnea from pulmogenic dyspnea.Methods The detection of plasma BNP was carried out in 248 patients with dyspnea.The apparatus was the CENTUR type chemiluminescence detection produced by the Bayer companies of USA.All patients were divided into three groups depending on disease severity.The level of plasma BNP in each group wag compared.Results The level of plasma BNP in pulmonary disease complicated with left ventricular dysfunction was higher than that of pulmonary disease non-complicated with left ventricular dysfunction.There was significant difference between two groups (χ²=25.597,P<0.001).The level of plasma BNP in pulmonary disease complicated with right ventricular dysfunction was higher than that of simple pulmonary disease.There was no significant difference between two groups (t=1.614,P>0.05).The level of plasma BNP in pulmonary disease complicated with left ventricular dysfunction was higher than that of pulmonary disease complicated with fight ventricular dysfunction.There Was significant difference between two groups (t=2.53 l,P<0.05).If the left ventricular dysfunction degree was notable,the level of plasma BNP waft,high.There was also significant difference in different cardiac function classification by New York Heart Association (χ²=29.463,P<0.001).Conclusion Plasma BNP analysis is an impotent method for differentiating cardiogenic dyspnea from pulmogenie dyspnea.Meanwhile,it is also helpful to evaluating the severity of pulmonary disease complicated with left ventricular dysfunction.