经肝动脉灌注<sup>90</sup>Y微球治疗肝癌的研究进展

周云; 刘璐; 宋进华

经肝动脉灌注⁹⁰Y微球治疗肝癌的研究进展

周云 , 刘璐 , 宋进华

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 6: (321-324)

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经肝动脉灌注⁹⁰Y微球治疗肝癌的研究进展

1. 210009 南京, 东南大学核医学技术研究所;
2. 210006 南京, 南京医科大学附属南京第一医院放射介入科

通讯作者: 刘璐, luliuzhou@sina.com ;

基金项目:
国家自然科学基金资助项目(30470500)
中图分类号: R817.8

Clinical researched progress of intra-arterial radioembolization with ⁹⁰Y-glass microspheres for treatment of hepatocellular carcinoma

1. Department of Nuclear Medical Technique, Southeast University, Nanjing 210009, China;
2. Department of Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

Corresponding author: LIU Lu, luliuzhou@sina.com ;

CLC number: R817.8

摘要: 近年来,肿瘤核素内照射治疗的研究取得了很大的进展。⁹⁰Y被视为绿色无公害核素备受关注。⁹⁰Y玻璃微球通过肝动脉给药,可以发挥栓塞肿瘤供血动脉和内照射治疗肿瘤的双重作用,具有操作简单、适应证广泛、不良反应少及肿瘤响应明显等优点,有效地提高了患者的生存率和中位生存期。随着微球材料技术的进一步发展,⁹⁰Y微球肝动脉灌注可能成为治疗肝癌患者安全有效、具有广阔临床应用前景的新方法。
- 癌,肝细胞 /
- 钇放射性同位素 /
- 放射学,介入性 /
- 栓塞,治疗性
Abstract: In recent years, the research of tumor nuclide internal radiation treatment has been carried out encouraging result. ⁹⁰Y has been regarded green non-environmental damage nuclide. Intrahepatic arterial injection of ⁹⁰Y-glass microspheres perform dual function at embolism tumor blood supply artery and the internal radiation treatment tumor. It has many merits include simplified operation, wide-ranging indication, side effect few and the tumor response obvious. And the patient's survival rate and position lifetime has been effective enhanced. Along with the further development of microspheres material technique, this method will entirely possible to achieve a new effective and safe therapy for the patient and has extensively clinical foreground.
- Carcinoma, hepatocellular /
- Yttrinm radioisotopas /
- Radiology, interventional /
- Embolization, therapeutic
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Staunton M, Dodd JD, McCormick PA, et al. Finding evidence-based answers to practical questions in radiology:which patients with inoperable hepatocellular carcinoma will survive longer afte transarterial chemoembolization?. Radiology, 2005, 237(2):404-413.
[2]	Carr BI. Hepatocellular carcinoma:current management and futuret rends. Gastroenterology, 2004, 127(5 Suppl 1):S218-S224.
[3]	Berdonosov SS, Berdonosova DG, Znamenskaya NV. Sorption of ⁹⁰Sr and ⁹⁰Y with the vaterite modification of calcium carbonate.Radiochemistry, 2003, 45(6):613-615.
[4]	Ho S, Lau WY, Leung TW, et al. Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer. Eur J Nucl Med, 1997,24(3):293-298.
[5]	Wong CY, Salem R, Qing F, et al. Metabolic response after intraarterial ⁹⁰Y-glass microsphere treatment for colorectal liver metastases:comparison of quantitative and visual analyses by ¹⁸F-FDG PET. J Nucl Med, 2004, 45(11):1892-1897.
[6]	Salem R, Lewandowski R, Roberts C, et al. Use of Yttrium-90 glass microspheres (Thera-Sphere) for the treatment of unresectable hepatocellular carcinoma in patients with portal vein thrombosis. J Vasc Interv Radiol, 2004, 15(4):335-345.
[7]	Cao X, He N, Sun J, et al. Hepatic mdioembolization with Yttrium-90 glass microspheres for treatment of primary liver cancer. Chin Med J (Engl), 1999, 112(5):430-432.
[8]	Dancey JE, Shepherd FA, Paul K, et al. Treatment of nonresectable hepatocellular carcinoma with intrahepatic ⁹⁰Y microspheres. J Nucl Med, 2000, 41(10):1673-1681.
[9]	Sarfaraz M, Kennedy AS, Lodge MA, et al. Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma. Med Phys, 2004, 31(9):2449-2453.
[10]	Kennedy AS, Nutting C, Coldwell D, et al. Pathologic response and microdosimetry of (90)Y microspheres in man:review of four explanted whole livers. Int J Radiat Oncol Biol Phys, 2004, 60(5):1552-1563.
[11]	Leung DA, Coin JE, Sickles C, et al. Determinants of postembolization syndrome following hepatic chemoembolization. J Vase Interv Radiol, 2001, 12(3):321-326.
[12]	Salem R, Thurston KG, Carr BI, et al. Yttrium-90 microspheres:radiation therapy for unresectable liver cancer. J Vasc Interv Radiol, 2002, 13(9 Pt 2):S223-S229.
[13]	Salem R, Lewandowski RJ, Atassi B, et al. Treatment of unresectable hepatocellular carcinoma with use of ⁹⁰Y microsphere (Thera-Sphere):safety, tumor response, and survival. J Vasc Interv Radiol,2005, 16(12):1627-1639.
[14]	Ahmad J, Bhee J, Carr BI. The effects of hepatic artery chemotherapy on viral hepatitis in patients with hepatocellular carcinomal. Dig Dis Sic, 2005, 50(2):331-335.
[15]	Ebied OM, Federle MP, Cart BI, et al. Evaluation of responses to chemoembolization in patients with unresectable hepatocellular carcinoma. Cancer, 2003, 97(4):1042-1050.
[16]	Carr BI-Hepatic arterial ⁹⁰Yttrium glass microspheres (Therasphere) for unresectable hepatocellular carcinoma:interim safety and survival data on 65 patients. Liver Transpl, 2004, 10(2 Suppl 1):S107-S110.
[17]	Geschwind JF, Salem R Carr BI, et al. Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Gastroenterology,2004, 127(Ssupp11):S194-S205.
[18]	Lee HS, KIm JS, Choi IJ, et al. The safety and efficacy of transcatheter arterial chemcembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction. Cancer,1997, 79(11):2087-2094.

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经肝动脉灌注⁹⁰Y微球治疗肝癌的研究进展

通讯作者: 刘璐, luliuzhou@sina.com;

1. 210009 南京, 东南大学核医学技术研究所;
2. 210006 南京, 南京医科大学附属南京第一医院放射介入科

收稿日期: 2006-04-23

基金项目: 国家自然科学基金资助项目(30470500)

关键词:

摘要: 近年来,肿瘤核素内照射治疗的研究取得了很大的进展。⁹⁰Y被视为绿色无公害核素备受关注。⁹⁰Y玻璃微球通过肝动脉给药,可以发挥栓塞肿瘤供血动脉和内照射治疗肿瘤的双重作用,具有操作简单、适应证广泛、不良反应少及肿瘤响应明显等优点,有效地提高了患者的生存率和中位生存期。随着微球材料技术的进一步发展,⁹⁰Y微球肝动脉灌注可能成为治疗肝癌患者安全有效、具有广阔临床应用前景的新方法。

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经肝动脉灌注90Y微球治疗肝癌的研究进展

通讯作者: 刘璐, luliuzhou@sina.com ;

Clinical researched progress of intra-arterial radioembolization with 90Y-glass microspheres for treatment of hepatocellular carcinoma

Corresponding author: LIU Lu, luliuzhou@sina.com ;

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经肝动脉灌注90Y微球治疗肝癌的研究进展

通讯作者: 刘璐, luliuzhou@sina.com;

English Abstract

Clinical researched progress of intra-arterial radioembolization with 90Y-glass microspheres for treatment of hepatocellular carcinoma

Corresponding author: LIU Lu, luliuzhou@sina.com

全文HTML

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经肝动脉灌注⁹⁰Y微球治疗肝癌的研究进展

Clinical researched progress of intra-arterial radioembolization with ⁹⁰Y-glass microspheres for treatment of hepatocellular carcinoma

经肝动脉灌注⁹⁰Y微球治疗肝癌的研究进展

Clinical researched progress of intra-arterial radioembolization with ⁹⁰Y-glass microspheres for treatment of hepatocellular carcinoma