125I-脱氧尿苷治疗恶性肿瘤的研究进展

吴光 侯建全

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125I-脱氧尿苷治疗恶性肿瘤的研究进展

    通讯作者: 侯建全, xfl92@163.com
  • 基金项目:

    江苏省高校科研基金项目(Q1122031)

    江苏省135重点人才资助项目(RC2003094)

  • 中图分类号: R817.5

The therapeutic progression of 125I-UdR in malignant lesions

    Corresponding author: HOU Jian-quan, xfl92@163.com
  • CLC number: R817.5

  • 摘要: 125I是一种俄歇电子释放体,掺入细胞DNA分子后具有显著的细胞毒性,125I-脱氧尿苷(125I-UdR)能特异性掺入DNA合成的S期,是125I的良好载体。大量动物实验及临床试验已证实:肿瘤局部缓慢持续或反复间断注射,125I-UdR的抗肿瘤作用显著,且无明显全身不良反应。125I-UdR多局部给药,同时人们也在探索联合应用其他药物和改进局部给药方式,用以评价,125I-UdR的疗效及其安全性。
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出版历程
  • 收稿日期:  2007-04-23

125I-脱氧尿苷治疗恶性肿瘤的研究进展

    通讯作者: 侯建全, xfl92@163.com
  • 215006 苏州, 苏州大学附属第一人民医院泌尿外科
基金项目:  江苏省高校科研基金项目(Q1122031)江苏省135重点人才资助项目(RC2003094)

摘要: 125I是一种俄歇电子释放体,掺入细胞DNA分子后具有显著的细胞毒性,125I-脱氧尿苷(125I-UdR)能特异性掺入DNA合成的S期,是125I的良好载体。大量动物实验及临床试验已证实:肿瘤局部缓慢持续或反复间断注射,125I-UdR的抗肿瘤作用显著,且无明显全身不良反应。125I-UdR多局部给药,同时人们也在探索联合应用其他药物和改进局部给药方式,用以评价,125I-UdR的疗效及其安全性。

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