冠状动脉内放射治疗再狭窄的研究近况

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冠状动脉内放射治疗再狭窄的研究近况

    作者简介: 谭文庆(1970-),内科主治医师,主要从事心脏介入治疗的研究。;
  • 中图分类号: R817.5

Intracoronary radiotherapy for treatment of restenosis

  • CLC number: R817.5

  • 摘要: 血管成形术后再狭窄是一个临床常见问题,支架植入后再狭窄甚至达到20%或更高,特别是弥漫性血管再狭窄病变的治疗有一定的困难。为了防治再狭窄人们进行了许多研究,本文综述冠状动脉内放射治疗防治再狭窄的研究近况。
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    [2] Ajani AE, Waksman R, Sharma AK, et al. Three-year follow-up after intracomnary gamma radiation therapy for instent restenosis. Original WRIST. Washington Radiation for In-Stent Restenosis Trial[J]. Cardiovase Radiat Med, 2001,2(4): 200-204.
    [3] Waksman R, Ajani AE, White RL, et al. Prolonged antiplatelet therapy to prevent late thrombosis after intracoronary gamma-radiation in patients with in-stent restenosis: Washington Radiation for In-Stent Restenosis Trial Plus 6 months of clopidogrel (WRIST PLUS)[J]. Circulation, 2001,103(19): 2332-2335.
    [4] Waksman R, Ajani AE, Pinnow E, et al. Twelve versus six months of clopidogrel to reduce major cardiac events in patients undergoing gamma-radiation therapy for in-stent restenosis: Washington Radiation for In-Stent restenosis Tri-al (WRIST) 12 versus WRIST PLUS[J]. Circulation, 2002,106(7): 776-778.
    [5] Moses JW, Moussa I, Leon MB, et al. Effect of catheterbased iridium-192 gamma brachytherapy on the added risk of restenosis from diabetes mellitus after intervention for instent restenosis (subanalysis of the GAMMA I Randomized Trial)[J]. Am J Cardiol. 2002. 90(3): 243-247.
    [6] Lansky AJ, Dangas G, Mehran R,et al. Quantitative angiographic methods for appropriate end-point analysis, edgeeffect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation[J]. J Am Coll Cardiol, 2002, 39(2): 274-280.
    [7] Krueger K, Landwehr P, Zaehringer M, et al. Endovaseular gamma irradiation of femoropopliteal de novo stenoses immediately after PTA: interim results of prospective randomized controlled trial[J]. Radiology, 2002, 224(2): 519-528.
    [8] Waksman R, Bhargava B, White L, et al. Intra-coronary beta-radiation therapy inhibits recurrence of in-stent restenosis[J]. Circulation, 2000, 101(16): 1895-1898.
    [9] Raizner AE, Kaluza GL The proliferation reduction with vascular energy trial (PREVENT). Curr Control Trials[J].Cardiovase Med, 2001, 2(1): 16-19.
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    [11] Suntharalingam M, Laskey W, Lansky AJ, et al. Clinical and angiographic outcomes after use of 90Sr/90Y beta radiation for the treatment of in-stent restenosis: results from the stents and radiation therapy 40(START 40) registry[J]. Int J Radiat Oncol Biol Phys, 2002, 52(4): 1075-1082.
    [12] Hausleiter J, Li A, Makkar R, et al. Leakage of a liquid 188Re-filled balloon system during intracoronary brachytherapy. A case report[J]. Cardiovasc Radiat Med, 2000, 2(1): 7-10.
    [13] Knapp FF Jr, Guhlke S, Beets AL, et al. Endovascular beta irradiation for prevention of restenosis using solution radioisotopes: pharmacologic and dosimetric properties of rhenium-188 compounds[J]. Cardiovasc Radiat Med, 1999,1(1): 86-97.
    [14] Apple M, Waksman R, Chan RC, et al. Radioactive 133-Xenon gas-filled balloon to prevent restenosis: dosimetry,efficacy, and safety considerations[J]. Circulation, 2002,106(6): 725-729.
    [15] Albiero R, Nishida T, Adamian M, et al. Edge restenosis after implantation of high activity 32P radioactive beta-emitting stents[J]. Circulation, 2000, 101: 2454-2457.
    [16] Albiero R, Adamian M, Kobayashi N, et al. Short-and intermediate-term results of 32P radioactive beta-emitting stent implantation in patients with coronary artery disease.The Milan dose-response study[J]. Circulation, 2000, 101: 18-26.
    [17] van Der Giessen WJ, Regar E, Harteveld MS, et al."Edge Effect" of 32p radioactive stents is caused by the combination of chronic stent injury and radioactive dose falloff[J].Circulation, 2001, 104(18): 2236-2241.
    [18] Schiele TM, Staber L, Kantlehner R, et al. Edge effect and late thrombosis-inevitable complications of vascular brachytherapy[J]. Z Kardiol, 2002, 91(11): 869-878.
    [19] Kim HS, Waksman R, Chan RC, et al. Edge stenosis and geographical miss following intracoronary gamma radiation therapy for in-stent restenosis[J]. Am Coll Cardiol, 2001, 37(4): 1026-1030.
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  • 收稿日期:  2003-03-09

冠状动脉内放射治疗再狭窄的研究近况

    作者简介:谭文庆(1970-),内科主治医师,主要从事心脏介入治疗的研究。
  • 014010 包头, 包钢第三职工医院

摘要: 血管成形术后再狭窄是一个临床常见问题,支架植入后再狭窄甚至达到20%或更高,特别是弥漫性血管再狭窄病变的治疗有一定的困难。为了防治再狭窄人们进行了许多研究,本文综述冠状动脉内放射治疗防治再狭窄的研究近况。

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