星形胶质细胞的电离辐射损伤及修复作用

高荣莲; 陈肖华

星形胶质细胞的电离辐射损伤及修复作用

高荣莲 , 陈肖华

文章导航 > 国际放射医学核医学杂志 > 2004, 28 > 1: (37-40)

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星形胶质细胞的电离辐射损伤及修复作用

100850 北京, 军事医学科学院放射医学研究所
中图分类号: Q345⁺.21;R818.05

Injury and repair of astrocyte after ionizing radiation

Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China
CLC number: Q345⁺.21;R818.05

摘要: 星形胶质细胞(astrocyte, Ast)是中枢神经系统内最多的胶质细胞。体内外实验结果表明,电离辐射作用于神经系统后,可引起神经元、胶质细胞和血管内皮细胞等多种细胞的形态和功能变化。照射后早期Ast即可发生反应,与脑组织损伤后的病理过程及损伤后修复有着密切的联系。研究Ast在辐射损伤中的作用对于临床放射性脑损伤的治疗有着重要的意义。
- 星形胶质细胞 /
- 电离辐射 /
- 中枢神经系统
Abstract: Astrocyte is the most glial cell in the central nervous system.In the present experi-ment, radiation injury to the central nervous system(CNS)triggers a large network of cellular changes including neuron, glialcell and endothelial cell in morphology and metabolism and function.Astrocyte changes rapidly after ionizing radiation.There is a ralationship between astrocyte and the pathologic process and function recover of damaged brain tissue following CNS injury.This suggests that astrocyte plays an important role in cure of clinical radiation injury.
- astrocyte /
- ionizing radiation /
- central nervous system
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[1]	Nirmala C, Jasti SL, Sawaya R, et al. Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions[J]. Int J Cancer,2000, 88(5):766-771.
[2]	Kamiryo T, Kassell NF, Thai QA, et al. Histological changes in the normal rat brain after gamma irradiation[J]. Acta Neurochir (Wien), 1996, 138(4):451-459.
[3]	Yang T, Wu SL Liang JC, et al. Time-dependent astroglial changes after gamma knife radiosurgary in the rat firebrain[J]. Neurosurgery, 2000, 47(2):407-416.
[4]	Yuan H, Galoer MW, McColgan T, et al. Radiation-induced permeability and leukocyte adhesion in the rat blood brain barrier:modulation with anti-ICAM-1 antibodies[J]. Brain Res, 2003, 969(1-2):59-69.
[5]	Akiyama K, Tanaka R, Sato M, et al. Cognitive dysfunction and histological findings in adult rats one year after whole brain irradiation[J]. Neurol Med Chir, 2001, 41(12):590-598.
[6]	Ding GR, Nakahara T, Miyakoshi J. Exposure to power frequency magnetic fields and X-rays induces GAP-43 gene expression in human glima MO54 cells[J]. Bioelectromagnetics, 2002, 23(8):586-591.
[7]	Janeczko K, Setkowicz Z, Fraczek M, et al. Effects of prenatal gamma-irradiation on postnatal astrogliogenesis in the hippocampal formation of rat[J]. Brain Res, 1999, 816(2):628-632.
[8]	Kyrkanides S, John A, Olschowka JA, et al. TNF α and IL-1β me-diate intercellular adhesion molecule-1 induction via mi-croglia-astrocyte interaction in GNS radiation injury[J].Neu-roimmunol, 1999, 95:95-106.
[9]	Kim SH, lim DJ, Ghung YG, et al. Expression of TNF-α and TGF-β1 in the ret brain after a single high-dose Irradiation[J]. J Korean Med Sci, 2002, 17(2):242-248.
[10]	Kyrkanides S, Moore AH, Olschowka JA, et al. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury[J]. Mol Brain Res, 2002,4(2):159-169.
[11]	Janeczko K, Pawlinski R, Setkowicz Z, et al. Long-term postnatal effect of prenatal irradiation on the astrocyte proliferative response to brain injury[J]. Brain Res, 1997, 770(1-2):237-241.
[12]	Setkowicz Z, Krzysztof J. Effects of prenatal gamma-irradiation on the astrocyte proliferation in response to injury in the brain of 6-day-old rat[J]. Brain Res, 1998, 803:122-128.
[13]	Yanagala K, Tagami M, Nara Y, et al. Astrocyte-conditioned medium induces blood-brain barrier properties in endothe-lial cells[J]. Clin Exp Pharmacol Physiot, 1997(9-10), 24:710-713.
[14]	SchousboeA. Role ofastrocytes in the maintenance and modulation of glutamatergic and GABA ergic neurotransmis-sion[J]. Neurochem Res, 2003, 28(2):347-352.
[15]	Brouazin-Jousseame V, Guitton N, legue F, et al. GSH leve and Ⅱ-6 production increased in Sertoli cells and astrocytes after gamma irradiation[J]. Anticancer Res, 2002, 22(1A):256-262.

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星形胶质细胞的电离辐射损伤及修复作用

100850 北京, 军事医学科学院放射医学研究所

收稿日期: 2003-06-27

关键词:

摘要: 星形胶质细胞(astrocyte, Ast)是中枢神经系统内最多的胶质细胞。体内外实验结果表明,电离辐射作用于神经系统后,可引起神经元、胶质细胞和血管内皮细胞等多种细胞的形态和功能变化。照射后早期Ast即可发生反应,与脑组织损伤后的病理过程及损伤后修复有着密切的联系。研究Ast在辐射损伤中的作用对于临床放射性脑损伤的治疗有着重要的意义。