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肝癌为我国常见的恶性肿瘤之一,其侵袭性强、预后差,早期诊断、分期及疗效评估可以指导医师选择正确的治疗方法,改善患者预后[1]。PET/CT已成为肝脏肿瘤筛查及诊断的重要分子影像学技术。在临床工作中,对于具有典型肝癌影像学征象的患者,诊断比较简单,但对缺乏特异性的患者的诊断较困难。本研究阐述了一例18F-FDG联合18F-胸腺嘧啶脱氧核苷(18F-fluoro-3′-deoxy-3′-L-fluorothymidine,18F-FLT)诊断原发性高分化肝癌的诊治过程,以提高诊断水平。
18F-FLT联合18F-FDG诊断高分化肝癌一例
18F-FLT combined with 18F-FDG in the diagnosis of highly differentiated hepatocellular carcinoma: a case report
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摘要: 笔者报道了一例18F-FDG联合18F-胸腺嘧啶脱氧核苷(18F-FLT)诊断原发性高分化肝癌的显像病例,从临床症状、实验室检查、影像学等方面分析该病特点,阐述了PET/CT在肝脏疾病诊断中的优势,同时指出18F-FDG在肝癌诊断中的不足,并通过文献回顾了18F-FLT、11C-乙酸盐在肝癌中的应用。不同显像剂的联合使用对肝脏占位的诊断具有重要价值。Abstract: The author reported one case of 18F-FDG imaging combined with 18F fluorothymidine(18F-FLT) in the diagnosis of primary highly differentiated hepatocellular carcinoma. The characteristics of the disease were analyzed according to clinical symptoms, laboratory examinations, and radiology. The advantages of PET/CT in the diagnosis of liver diseases were expounded, and the deficiency of 18F-FDG in the diagnosis of liver cancer was indicated. The literature on the application of 18F-FLT 11C-acetate to hepatocellular carcinoma was reviewed. This study concluded that the combined use of different imaging agents is of great value in the diagnosis of liver-occupying lesions.
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