妊娠糖尿病患者超敏C反应蛋白动态变化与胰岛素抵抗的关系

邹钢 ,  胡晓蓉 ,  李翠吟 ,  邵豪 ,  陆泽元 ,  赖丽萍 ,  柳岚 ,  马江涛

downloadPDF
文章导航 > 国际放射医学核医学杂志  > 2008,  32 > 4: (232-235)  
引用本文:
shu
Citation:
shu

妊娠糖尿病患者超敏C反应蛋白动态变化与胰岛素抵抗的关系

  • 1. 518033 深圳, 深圳市福田人民医院内分泌科;

  • 2. 518033 深圳, 深圳市福田人民医院妇产科;

  • 3. 518020 深圳, 深圳市人民医院检验医学部

    • 通讯作者: 邹钢, zhenjin1969@yahoo.com.cn ; 
  • 基金项目:

    深圳市科技计划项目(卫生医疗类)(200803145)

Alteration of serum high-sensitivity C-reactive protein level in gestational diabetes mellitus and correlation with in insulin resistance

  • 1. Department of Endocrinology, The Futian People's Hospital, Shenzhen 518033, China;

  • 2. Department of Gastroenterology, The Futian People's Hospital, Shenzhen 518033, China;

  • 3. Department of Laboratory, The Shenzhen People 0 Hospital, Shenzhen 518020, China

    • Corresponding author: ZOU Gang, zhenjin1969@yahoo.com.cn ;

  • 摘要: 目的 探讨妊娠糖尿病患者超敏C反应蛋白(hs-CRP)动态变化与胰岛素抵抗(IR)的关系。方法 选择妊娠糖尿病(GDM)患者32例和正常糖耐量(NGT)孕妇3l例为研究对象,分别测定孕25~28周、孕29~32周、孕37~38周、产后6~8周空腹血清hs-CRP、空腹胰岛素(FINS)、空腹血糖(FBG)水平,采用放射免疫法测定FINS,葡萄糖氧化酶法测定FBG,免疫散射比浊法测定hs-CRP,以HOMA胰岛索抵抗指数(HOMA-IR)评价IR。结果 (1) GDM组和NGT组血清hs-CRP水平在妊娠各阶段(孕25~28周、孕29~32周、孕37~38周)的变化不明显,但均显著高于产后;(2) GDM组妊娠各阶段血清hs-CRP水平均高于NGT组(t值分别为7.31、7.78、6.33,P<0.01);(3) GDM组妊娠各阶段HOMA-IR均显著高于NGT组(t值分别为31.18、31.10、28.39,P<0.01);(4) Pearson相关分析显示。FBG、FINS、hs-CRP与HOMA-IR显著相关(相关系数分别为0.478、0.902、0.293,P<0.01),多元回归分析提示,FINS、FBG、hs-CRP是影响HOMA-IR的显著因素(回归系数分别为0.441、0.876、0.261,P<0.01)。结论 GDM患者血清hs-CRP水平在妊娠的不问阶段变化不明显,但显著高于NGT组,且与HOMA-IR显著相关。
    Abstract: Objective To explore the dynamic of high-sensitivity C-reactive protein (hs-CRP) and its correlation with insulin resistance (IR) during different stages of gestational diabetes mellitus (GDM). Methods Thirty-two subjects with GDM and thirty-one cases of normal glucose tolerance (NGT) pregnant women were enrolled in the study,fasting insulin (FINS) were determined by radioimmunoassay,the fasting blood glucose (FBG) was measured by using glucose oxidase,immunoturbidimetry performed to evaluate serum hs-CRP levels.Tests repeated for each group according different stages of prenatal 25-28 weeks,29-32 weeks,37-38 weeks and postpartum 6-8 weeks.IR was assessed by the homeostasis model assessment insulin resistance index (HOMA-IR),Results ①Serum hs-CRP levels in NGT and GDM had few change with gestational age,but both significantly decreased at postpartum.②Serum hs-CRP levels in GDM significantly increased than NGT in the same stage (t was 7.31,7.78,6.33,respectively,P<0.01).③HOMA-IR in GDM significantly increased than NGT in the same gestational stage (t was 31.18,31.10, 28.39,respectively,P<0.01).④Pearson correlation analysis showed that FBG,FINS and hs-CRP had significant association with HOMA-IR (regression coefficient of 0.478,0.902,0.293,respectively,P<0.01). Multiple regression analysis identified FINS,FBG and hs-CRP as the factors significantly affecting HOMA-IR (regression coefficient of 0.441,0.876,0.261,respectively,P<0.01).Conclusion Serum hs-CRP levels in GDM had few change with gestational age,but all significantly increased than NGT in the same stage,and which were the most significant factors affecting HOMA-IR.
  • [1] Garcia DM,Marks JE,Latifl HR el al.Childhood eerebellar astrocytomas:is there a role for postoperative irradiation?[J].Int J Radiat Oneol Biol Phys,1990,18(4):815-818.
    [2] 陈智,李旭,张宇,等.脑恶性胶质瘤82例放射治疗疗效分析[J].中华放射医学与防护杂志,2006,26(4):410-410.
    [3] 梅国顺,杜建新.脑恶性胶质瘤的局部治疗现状[J].中华神经外科疾病研究杂志,2007,4(6):379-381.
    [4] Eyüpeoglu IY,Hahnen E,Buslei R,et al.Subereylanilide hydroxamie acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo[J].J Neurochem,2005,93(4):992-999.
    [5] Nieholas A,Butowski,Patrieia K,et al.Diagnosis and treatment of recurrent higll-grade astrecytoma[J].J Clin Oncol,2006,24(8): 1273-1280.
    [6] Kropacova k Slovinskn L,Misurova E.Cytogenetie changes in the liver of progeny of irradiated male rats[J].J Radia Res,2002,43(2): 125-133.
    [7] Khmelevskii EV.Radiotherapy for recurrent breast cancer[J]. Voprosy Onkologii,2000,46(2):167-171.
    [8] Pelevina II,Gotlib VIa,Kudriashova OV,et al.Properties of progeny of irradiated cells[J].Tsitologiia,1998,40(5):467-477.
    [9] 刘树铮.适应性反应[J].中华放射医学与防护杂志,2000,20(6): 373-377.
    [10] 姜桔红,王捷,余忠华,等.照射存活后代的鼻咽癌细胞株放射生物学特性研究[J].实用癌症杂志,2002,26(4):566-568.
    [11] Graf R,Hildebrandt B,Tilly W.et al.Dose-escMated conformal radiotherapy of glioblastomas-results of a retrospective comparison applying radiation doses of 60 and 70 Gy[J].Onkologie,2005,28(6-7):325-330.
    [12] Ulm AJ 3rd,Friedman WA,Bradshaw P.et al.Radiosurgery in the treatment of malignant gliomas:the University of Florida experience[J].Neurosurgery,2005,57(3):512-517.
    [13] Cardinale R,Won M,Choucair A,et al.A phaseⅡ trial of accelerated radiotherapy using weekly stereotaetie conformal boost for supratentorial glioblastoma multiform:RTOG 0023[J].Int J Radiat Oncol Biol Phys,2006,65(5):1422-1428.
    [14] Graf R,Hildebrandt B,Tilly W,et al.Dose-escalated confomud radiotherapy of glioblastomas-results of a retrospective comparison applying radiation doses of 60 and 70 Gy[J].Onkologle,2005,28(6-7):325-330.
    [15] Stupp R,Mason WP,vtul den Bent MJ,et al.Radiotherapy plus concomitant and adjuvant temomlomide for glioblastonut[J].N Engl J Med,2005,352(10):987-996.
    [16] Intergroup radiation therapy oncology group trial 9402.caimeross G,Berkey B,et al.Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglionm:Intergroup Radiation Therapy Oncology Group Trial 9402[J].J Clin Oncol,2006,24(18):2707-2714.
    [17] van den Bent MJ,Carpentier AF,Brandes AA,et al.Adjuvant proearbazine,Iomustine,and vincristine improve progression-free survival but not overall survival in newly diagnosed anaplastic oligodendroglionms and oligoastroeytomas:a randomized European Organization for Research and Treatment of Cancer phase III trial[J].J Clin Onenl,2006,24(18):2715-2722.
    [18] Anal S,Tanaka M,Shiveriek KT,et al.Increased expression of cyclooxygenase-2 correlates with resistance to radiation in human prostate adenoearcinoma cells[J].J Urol,2007,177(5):1913-1917.
    [19] Nakano Y,Kuroda E,Kito T.et al.Induction of macrophagie prostaglandin E2 synthesis by glioma cells[J].J Neurosurg, 2006.104(4):574-582.
    [20] Reardon DA,Quinn JA,Vredenburgh J,el al.Phase Ⅱ trial of irinotecan plus celecoxib in adults with recurrent malignant glioma[J].Cancer,2005,103(2):329-338.
  • [1] 邹钢 , 胡晓蓉 , 李翠吟 , 邵豪 , 陆泽元 , 赖丽萍 , 柳岚 . 妊娠糖尿病患者肿瘤坏死因子的动态变化与胰岛素抵抗的关系. 国际放射医学核医学杂志, 2009, 33(2): 93-96. doi: 10.3760/cma.j.issn.1673-4114.2009.02.009
    [2] 邹钢 , 邵豪 , 陆泽元 , 丁玉珍 , 陈观榕 , 傅娟 . 2型糖尿病胃轻瘫患者胰岛β细胞功能和胰岛素抵抗的评价及临床意义. 国际放射医学核医学杂志, 2005, 29(6): 261-264.
    [3] 杨觉雄 , 许樟荣 , 杨天恩 . 腹部放疗诱发糖尿病. 国际放射医学核医学杂志, 1996, 20(4): 188-188.
    [4] 赵红光 , 蔡露 , 龚守良 . 低剂量辐射与糖尿病. 国际放射医学核医学杂志, 2006, 30(1): 59-62.
    [5] . 抗体检查可诊断糖尿病于未然. 国际放射医学核医学杂志, 1996, 20(1): 25-25.
    [6] 陈文新 , 董惟誉 , 林祥通 . 胰岛素依赖型糖尿病患者的99mTc-HMPAO局部脑血流灌注SPECT研究. 国际放射医学核医学杂志, 1996, 20(6): 260-260.
    [7] 李阳 , 沈聪 , 袁网 , 丁晖 , 李艳 , 段小艺 , 杨健 , 张卫善 . 服用二甲双胍与胰岛素的糖尿病患者肠道摄取18F-FDG的比较. 国际放射医学核医学杂志, 2022, 46(5): 277-283. doi: 10.3760/cma.j.cn121381-202106005-00181
    [8] 朱灿胜 . 放射性核素显像在糖尿病足诊治中的应用. 国际放射医学核医学杂志, 2000, 24(4): 145-147.
    [9] 武志芳 . SPECT心肌灌注显像对糖尿病心肌缺血损伤的研究. 国际放射医学核医学杂志, 2004, 28(3): 105-108.
    [10] 金稚奎 , 马材芳 , 谭天秩 . 放射性核素探测糖尿病时的血-视网膜屏障破坏. 国际放射医学核医学杂志, 1985, 9(2): 125-125.
    [11] 姚立新 , 李昨非 , 刘波 , 郭雷鸣 . 99Tcm-DTPA核素肾动态显像对糖尿病肾功能的评价. 国际放射医学核医学杂志, 2009, 33(6): 343-346. doi: 10.3760/cma.j.issn.1673-4114.2009.06.007
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  1598
  • HTML全文浏览量:  203
  • PDF下载量:  2
出版历程
  • 收稿日期:  2008-03-21

妊娠糖尿病患者超敏C反应蛋白动态变化与胰岛素抵抗的关系

    通讯作者: 邹钢, zhenjin1969@yahoo.com.cn; 
  • 1. 518033 深圳, 深圳市福田人民医院内分泌科;
  • 2. 518033 深圳, 深圳市福田人民医院妇产科;
  • 3. 518020 深圳, 深圳市人民医院检验医学部
  • 收稿日期: 2008-03-21
基金项目:  深圳市科技计划项目(卫生医疗类)(200803145)

摘要: 目的 探讨妊娠糖尿病患者超敏C反应蛋白(hs-CRP)动态变化与胰岛素抵抗(IR)的关系。方法 选择妊娠糖尿病(GDM)患者32例和正常糖耐量(NGT)孕妇3l例为研究对象,分别测定孕25~28周、孕29~32周、孕37~38周、产后6~8周空腹血清hs-CRP、空腹胰岛素(FINS)、空腹血糖(FBG)水平,采用放射免疫法测定FINS,葡萄糖氧化酶法测定FBG,免疫散射比浊法测定hs-CRP,以HOMA胰岛索抵抗指数(HOMA-IR)评价IR。结果 (1) GDM组和NGT组血清hs-CRP水平在妊娠各阶段(孕25~28周、孕29~32周、孕37~38周)的变化不明显,但均显著高于产后;(2) GDM组妊娠各阶段血清hs-CRP水平均高于NGT组(t值分别为7.31、7.78、6.33,P<0.01);(3) GDM组妊娠各阶段HOMA-IR均显著高于NGT组(t值分别为31.18、31.10、28.39,P<0.01);(4) Pearson相关分析显示。FBG、FINS、hs-CRP与HOMA-IR显著相关(相关系数分别为0.478、0.902、0.293,P<0.01),多元回归分析提示,FINS、FBG、hs-CRP是影响HOMA-IR的显著因素(回归系数分别为0.441、0.876、0.261,P<0.01)。结论 GDM患者血清hs-CRP水平在妊娠的不问阶段变化不明显,但显著高于NGT组,且与HOMA-IR显著相关。

English Abstract

    全文HTML

参考文献 (20)

目录

    /

    返回文章
    返回

    版权所有©中华医学会   备案号：津ICP备15006720号-3

    地址：天津市南开区白堤路238号电话：86-22-58089989
    86-22-85682389    传真：022-87890607

    本系统由 北京仁和汇智信息技术有限公司 开发 技术支持： info@rhhz.net