99Tcm-MIBI显像检测乳腺癌P-糖蛋白
Application of 99Tcm-MIBI scintimammography to diagnose P-gP of breast cancer
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摘要: 探讨了乳腺癌多药耐药的主要机制和99Tcm-MIBI SPECT检测P-糖蛋白在多药耐药中的研究进展。作为一种功能显像技术,99Tcm-MIBI SPECT能够无创伤性检测乳腺癌多药耐药,为临床治疗提供参考。
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关键词:
- 99Tcm-甲氧异丁基异腈 /
- 多药耐药 /
- P-糖蛋白
Abstract: The article discuss the advances in 99Tcm-sestamibi scintimammography to diagnose P-gly-coprotein of breast cancer in multidrug resistance. As a kind of noninvasive fuctional test imaging technology, SPECT can be used to diagnose P-glycoprotein expression in breast cancer and can make decision for clinical treatment.-
Key words:
- 99Tcm-sestamibi /
- multidrug resistance /
- P-glycoprotein
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[1] 周际昌.实用肿瘤内科学[M].北京:人民卫生出版社,2003.85.
[2] Galimberti S,Marchetti A,Buttitta F,et al.Multidrug resistance related genes and p53 expression in human NSCLC[J].Anticancer Res,1998,18(4C):2973-2976. [3] Trock BJ,Ceonessa F,Clarke R,et al.Multidrug resistance in breast cancer:A Meta-analysis of MDR1/gp-170 expression and its possible fuctional significance[J].J Natl Cancer Inst,1997,89:917-931. [4] 王树滨,刘雅洁,隋广杰等.P-糖蛋白在乳腺癌组织中的表达与预后的关系[J].中国肿瘤临床,2001,28(5):325-328.
[5] Cordobes MD,Starze A,Delmon-Moingeon L,et al.Technetium-99m-sestamibi uptake by human benign and malignant breast tumor cells:Corre lation with mdr gene expression[J].J Nucl Med,1996,37:286-289. [6] Vecchio SD,Ciarmiello A,Leonardo P,et al.Fractional retention of the technetium-99m-sestamibi as an index of P-glycoprotein rxpres-sion in untreated breast cancer patients[J].J Nucl Med,1997,38(9):1348-1351. [7] Kostakoglu L,Elahi N,Kiratli P,et al.Clinical validation of the influence of P-glycoprotein on technetium-99m-sestamibi uptake in malignant tumors[J].J Nucl Med,1997,38(7):1003-1008. [8] Nishiyama Y,Kawasaki Y,Yamamoto Y,et al.Technetium-99m-MIBI and thailium-201 scimtigraphy of primary lung cancer[J].J Nucl Med,1997,38(9):1358-1361. [9] Chia-Hung K,Shih-Chuan T,Liu TG,et al.P-glycpprotein and multidrug-related protein expressions in relation to technetium-99m methoxyisobutylisonitrile scintimammorgraphy findings[J].Cancer Res,2001,15(61):1412-1414. [10] Shung-Shung S,Tih-Fang H,Shih-chuan T,et al.Expression of mediated P-glycoprotein multidrug resistance related to Tc-99m MIBI scintimammography results[J].Cancer Lett,2000,153(1-2):95-100. [11] Del-Vecchio S,Ciarmiello A,Pue L,et al.Fractional retention of technetium-99m-sestamibi as an index of P-glycoprotein expression in untreated breast cancer patients[J].J Nucl Med,1997,38(9):1348-1351. [12] Del-Vecchio S,Ciarmiello A,Potena MI,et al.In Vivo detection of multidrug-resistance (MDR1) phenotype by technetium-99m ses-tamibi scan in untreated breast cancer patients[J].Eur J Nucl Med,1997,24(2):150-159. [13] Muriel A,Noreli F,Jean-Marc R,et al.Enhancement of mdr1 gene expression in normal tissue adjacent to advanced breast cancer[J].Breast Cancer Res Trea,2000,61(1):13-20. [14] Van de Vijver MJ,He YD,vant Veer LJ,et al.A gene-expression signature as a predictor of survival in breast cancer[J].Engl J Med,2002,347(25):1999-2009.
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