99mTc-HL91显像在缺血陛脑血管病中脑乏氧组织的应用研究
Preliminary study on detection of brain hypoxic tissue in the patients with ischemic cerebrovascular of brain using 99mTc-HLgl imaging
-
摘要: 目的 探讨99mTc-4,9-二氮。3,3,10,10-四甲基十二烷-2,11-二酮肟(99mTc-HL91)在缺血性脑血管病中脑乏氧组织的临床应用价值。方法 对9例对照组和17例急性脑梗死患者于起病7 d内进行脑乏氧显像,同时进行了CT或MRI检查。其中2例分别于第一次显像阳性后9 d和12 d进行第二次乏氧显像。结果 对照组未见脑实质有明显核素浓聚,左侧,右侧比值为0.98±0.04.17例急性脑梗死患者中,乏氧显像阳性11例,阳性率64.7%,其患侧/健侧比值为1.54±0.55,与对照组比较有显著性差异(t=3.081,P<0.05)。结论 99mTc-HL91显像可以区分乏氧与坏死的脑组织,对指导治疗、评价疗效有一定的临床意义。
-
关键词:
- 脑梗死 /
- 细胞低氧 /
- 缺血缺氧,脑 /
- 体层摄影术 /
- 发射型计算机,单光子
Abstract: Objective To investigate the detection of brain hypoxic tissue in patients with ischemic cerebrovaseular of brain using 99mTc-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime(99mTc-HL91)maging.Methods Nine controls and 17 patients with acute infarction of brain underwent 99mTc-HL91 imaging.Results The ratios of left/fight in controls is 0.98±0.04.The ratios of L/N in patients is 1.54±0.55.Conclusion 99mTc-HL91 imaging could detect brain hypoxie tissue after ischemic cerebrovascular of brain.-
Key words:
- Brain infarction /
- Cell hypoxia /
- Hypoxia-ischemia,brain /
- Tomography /
- emissioncomputed,single
-
[1] Bamford J, Sandercock P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction[J]. Lancet, 1991, 337(8756):1521-1526. [2] Heiss WD. Ischemic penumbra:evidence from functional imaging in man[J]. J Cereb Blood Flow Metab, 2000, 20(9):1276-1293. [3] 刘生, 王艺东, 蒋宁一, 等.99Tc m-HL91 SPECT显像检测急性脑梗死乏氧脑组织的研究[J].中华核医学杂志,2004,24(4):236-237.
[4] 冯珏, 冯亚青, 边艳珠, 等.新型乏氧显像剂99Tc m-HL91在缺血性脑血管病中的试验研究[J].中国医学影像技术,2003,19(2):164-166.
计量
- 文章访问数: 1437
- HTML全文浏览量: 106
- PDF下载量: 2