影响PET放射性药物<sup>11</sup>C甲基化的因素

张锦明; 田嘉禾; 刘伯里

影响PET放射性药物¹¹C甲基化的因素

张锦明 , 田嘉禾 , 刘伯里

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 5: (271-274)

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影响PET放射性药物¹¹C甲基化的因素

1. 100853 北京, 中国人民解放军总医院核医学科;
2. 100875 北京, 北京师范大学化学系

通讯作者: 刘伯里, liuboli@bnu.edu.cn

中图分类号: R817.9⁺2

Influence factor on ¹¹C methylation in PET radiopharmaceuticals

1. Department of Nuclear Medicine, The PLA General Hospital, Beijing 100853, China;
2. Department of Chemistry, Beijing Normal University, Beijing 100875, China

Corresponding author: LIU Bo-li, liuboli@bnu.edu.cn

CLC number: R817.9⁺2

摘要: ¹¹C甲基化是PET放射性药物合成重要方法之一,包括C-N、C-O、C-S甲基化等。影响¹¹C甲基化的因素有:甲基化试剂、进攻试剂碱性、溶剂极性和空间位阻等。当化合物上有2个以上进攻原子时,可通过调整甲基化试剂或溶剂的极性,使其中1个进攻原子的甲基化成为主要反应。
- 碳放射性同位素 /
- 甲基化 /
- 体层摄影术,发射型计算机 /
- 药物设计
Abstract: ¹¹C methylation was very important methods for synthesis of PET radiopharmaceuticals. It included C-N, C-O, C-S methylation and so on. There are many influence factors for ¹¹C methylation, such as methylation agents, the base of reagents, the polarity of solvent, the obstruct of space. We can adjust the methylation agent or change solvent in order to make one reaction as main reaction when a compound had two activity atoms.
- Crabon radioisotopes /
- Methylation /
- Tomography, emission-computed /
- Drug design
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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