环氧合酶-2抑制剂及其辐射增敏效应

周乐源; 周菊英

环氧合酶-2抑制剂及其辐射增敏效应

周乐源 , 周菊英

文章导航 > 国际放射医学核医学杂志 > 2005, 29 > 3: (129-131)

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环氧合酶-2抑制剂及其辐射增敏效应

215006 苏州, 苏州大学附属第一医院放射治疗科
中图分类号: R730.55

COX-2 inhibitors and enhancement of tumor radiosensitivity

Department of Radiation Oncology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China
CLC number: R730.55

摘要: 环氧合酶-2(COX-2)抑制剂因其广泛的预防和抑制肿瘤作用,近年来得到人们的关注。COX-2抑制剂与射线合并作用于肿瘤细胞时产生了辐射增敏现象,增敏的机制可能是COX-2抑制剂改变了细胞周期分布,抑制细胞的亚致死性损伤修复,提高对辐射诱导凋亡易感性等。
- 环氧合酶-2 /
- 辐射增敏 /
- 肿瘤
Abstract: Cyclooxygenase-2(COX-2) inhibitors has recently received extensive attention for its role in prevention and inhibition of malignancies. COX-2 inhibitors are enhancers of tumor cells response to irradiation. The possible mechanisms consist of effect on cell cycle distribution, inhibition of repair from sublethal radiation damage, increasing susceptibility of cells to radiation-induced apoptosis.
- cyclooxygenase-2 /
- radiosensitization /
- tumor
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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