辐射损伤与细胞周期

姚莉

辐射损伤与细胞周期

姚莉

100850 北京, 北京军医学院病理学教研室讲师
中图分类号: Q253;Q811.5

Radiation injury and cell cycle

YAO Li

Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China
CLC number: Q253;Q811.5

摘要: 辐射后的细胞可能发生恶性转化,可能死亡,另有一些细胞对辐射却产生适应性或抗性,最终长期存活下来。近年来研究发现,此差异与辐射对细胞周期的影响密切相关。辐射可阻断细胞周期活动及延长细胞周期,其中G₁期、S期和G₂/M期等细胞周期检查点(checkpoint)起决定作用,它们分别通过不同的信号途径对辐射所致的损伤进行调控,产生不同的辐射生物学效应。对该领域的深入研究不仅为进一步阐释辐射致癌提供一定的理论依据,而且为临床放疗增敏剂的研制提供新的思路。
- 辐射 /
- 细胞周期 /
- 调控 /
- 检查点
Abstract: Some may be malignant transformation, some may die immediately, and the other may be alive which produce radioadaptive responses and radioresistance.Recently, it has been reported that there is close relationship between cell cycle alterations and different injury effects caused by radiation.Cell cycle may be arrested and delayed by irradiation in which G₁-phase, S-phase and G₂/M-phase checkpoints may play a major role.Therefore different signal transduction pathways and moleculars are involved in the checkpoints responses.Furthermore, studies on the cell cycle checkpoints responses to radiation are quite important in radiation biology, because it could not only provide the theorical basis for the elucidation of cancer caused by radiation, but also gain further insight into investigation and developing radiosensitive drugs for clinical radiotherapy.
- radiation /
- cell cycle /
- regulation /
- checkpoints
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辐射损伤与细胞周期

100850 北京, 北京军医学院病理学教研室讲师

收稿日期: 2003-08-28

关键词:

辐射 /
细胞周期 /
调控 /
检查点

摘要: 辐射后的细胞可能发生恶性转化,可能死亡,另有一些细胞对辐射却产生适应性或抗性,最终长期存活下来。近年来研究发现,此差异与辐射对细胞周期的影响密切相关。辐射可阻断细胞周期活动及延长细胞周期,其中G₁期、S期和G₂/M期等细胞周期检查点(checkpoint)起决定作用,它们分别通过不同的信号途径对辐射所致的损伤进行调控,产生不同的辐射生物学效应。对该领域的深入研究不仅为进一步阐释辐射致癌提供一定的理论依据,而且为临床放疗增敏剂的研制提供新的思路。

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辐射损伤与细胞周期

Radiation injury and cell cycle

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辐射损伤与细胞周期

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Radiation injury and cell cycle

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辐射损伤与细胞周期

Radiation injury and cell cycle

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辐射损伤与细胞周期

English Abstract

Radiation injury and cell cycle

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