瘦素和体重调节反馈模式的研究

雷呈志

瘦素和体重调节反馈模式的研究

雷呈志

文章导航 > 国际放射医学核医学杂志 > 2002, 26 > 2: (60-63)

引用本文:

Citation:

瘦素和体重调节反馈模式的研究

雷呈志

300192 天津, 中国医学科学院放射医学研究所

作者简介: 雷呈志(1973-),男,山西太原人,山西医科大学第一医院住院医师,影像与核医学专业硕士研究生,主要从事激素检测的临床应用研究。;

中图分类号: R446.6

Studies on leptin and its feedback system for weight regulation

LEI Cheng-zhi

Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China
CLC number: R446.6

摘要: 瘦素(Leptin)被认为是一种外周组织反映脂肪量的信号,反馈作用于中枢神经系统。近年来,瘦素的负反馈系统已被部分揭示。下丘脑调节食欲和代谢的中枢受多种分子的协同作用,包括瘦素、神经肽Y(NPY),前阿片类黑色素原(POMC)等。根据已有的对瘦素的理解,建立一个关于瘦素负反馈的模型,可加深了解体内食欲和能量平衡调节机制。
- 瘦素 /
- 神经肽Y /
- 前阿片黑色皮质素
Abstract: Recently the hormone leptin has been regarded as hormonal signal linking adipose tissue status with a number of key central nervous system circuits. The role of leptin and its feedback system in man is partly revealed. Hypothalamic centers appear to control appetite, metabolic rate and activity level in a coordinate manner. Within the hypothalamus, known weight regulatory molecules include leptin, neuropeptide Y and POMC. We integrated new information into a revised model for understanding this important regulatory process. Our model of energy homeostasis propose that the inter-action of leptin with various neuroendocrine pathway in the brain and in the periphery to affect food-take.
- leptin /
- neuropeptideY /
- pro-opiomelanocortin
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Cumin F,Baum HP,Levens N, et al. Leptin is cleared from the circulation primimarily 6y the kidney[J].Int J Obes Relat Metab Disord,1996,20:1120-1126.
[2]	Gwo-Hwa L,Proenca R,Montez, et al. Abnormal splicing of the leptin receptor in diabetic mice[J].Nature,1996,379:632-635.
[3]	Emilsson V,Liu YL,Cawthorn MA, et al. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin of leptin on insulin secretion[J].Diabetes,1997,46:313-316.
[4]	Rowland NE,Morien A,Li BH, et al. The physiology and brain mechanisms of feeding[J].Nutrition,1996,12:626-639.
[5]	Caro J,Kolazcynski JW,Nyce MR, et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity:a possible mechanism for leptin resistance[J].Lancet,1996,348:159-161.
[6]	Woods A J,Stock MJ. Leptin activation in hypothalamus[J].Nature,1996,381:745.
[7]	Stephens TW,Basinski M,Bristow M, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product[J].Nature,1995,377:530-532.
[8]	Elmquist JK,Ahima RS,Maratos-Flier E, et al. Leptin activates neurons in ventrobasal hypothalamus and brainstem[J].Endoogy,1997,138:839-842.
[9]	Schwartz MW,Baskin DG,Bukowski TR, et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice[J].Diabetes,1996,45:531-535.
[10]	Erickson JC,Clegg KE,Palmiter RD, et al. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y[J].Nature,1996,381:415-418.
[11]	Rosenbaum M,Nicolson M,Hirsch J, et al. Effects of gender,body composition,and Menopause on plasma concen trantions of leptin[J].Clin in Endo Metab,1996,81:3424-3427.
[12]	Saad MF,Damani S,Gingerich RL, et al. Sexual dimorphism in plasma leptin concentration[J].Clin Endo Metab,1997,82:579-584.
[13]	Ishida K,Murakami T,Mizuno, et al. Leptin suppresses basal insulin secretion from rat pancreatic islets[J].Regul Pept,70:179-182.
[14]	He B,White BD,Edwards GL, et al. 2-Deoxy-D-glucose and NPY gene expression in the arcuate nucleus and specific brainstem nuclei in the rat[J].FASEB J,1995,9:582.
[15]	Bergen H T,Mizuno T M,Taylor J, et al. Hyperphagia and weight gain after gold-thioglucose relation to hypothalamic neuropeptide Y and proopio-melanocortin[J].Endocrinology,1998,139:4483-4488.
[16]	Blanchard SG,Harris CO,Ittoop OR, et al. Agouti antagonism of melanocortin binding and action in the B16F10 murine melanoma cell line[J].Biochemistry,1995,34:10406-10411.
[17]	Qu D,Ludwing DS,Gammeltoft S, et al. A role for melaninconcentrating hormone in the central regulation of feeding behaviour[J].Nature,1996,380:243-247.
[18]	Ludwing DS,Mountjoy KG,Tatro JB, et al. Melaninconcentrating hormone:a functional melanocortin antagonist in the hypothalamus[J].Am J Physiol,1998,274:E627-E633.
[19]	Banks WA,Kastin AJ,Huang W, et al. Leptin enters the brain by a saturable system independent of insulin[J].Peptides,1996,17:305-311.

[1]	赵明辉 . 瘦素应用于肥胖症研究. 国际放射医学核医学杂志, 2001, 25(5): 193-198.
[2]	王金萍 , 吴秋莲 , 徐浩 . 甲状腺功能与血清饥饿素和瘦素水平的相关陛研究. 国际放射医学核医学杂志, 2008, 32(4): 221-223.
[3]	朱文茹 , 左书耀 . 瘦素的表达与肿瘤的关系. 国际放射医学核医学杂志, 2005, 29(4): 164-166.
[4]	陈宁琳 , 鲍逸民 , 杨永青 . 血浆ATⅡ、NPY、IGF-1和hs-CRP水平测定在评估冠心病患者严重程度中的应用价值. 国际放射医学核医学杂志, 2014, 38(3): 167-170. doi: 10.3760/cma.j.issn.1673-4114.2014.03.007
[5]	濮伟刚 , 谭纪伏 , 朱建华 , 杨永青 . 血浆中四种肿瘤标志物和¹³C-尿素呼气试验对胃癌诊断的对比研究. 国际放射医学核医学杂志, 2010, 34(2): 94-96, 104. doi: 10.3760/cma.j.issn.1673-4114.2010.02.008
[6]	刘义明 , 揭育丽 . 充血性心力衰竭患者肾上腺髓质素与内皮素、血管紧张素Ⅱ结果比较. 国际放射医学核医学杂志, 2007, 31(2): 96-97,101.
[7]	王雪梅 , 何玉林 , 王爽 , 吴君 , 赵周社 . 心脏肾上腺素能神经的PET应用. 国际放射医学核医学杂志, 2009, 33(1): 14-17. doi: 10.3760/cma.j.issn.1673-4114.2009.01.014
[8]	林福生 , 李凤英 , 马寄晓 . ¹³¹碘化胆固醇闪烁扫描与罕见的功能性肾上腺皮质黑色腺瘤. 国际放射医学核医学杂志, 1984, 8(4): 249-249.
[9]	黄俊星 , 王吉欣 , 林汉 . ¹¹¹In-DTPA-澳曲肽用于小细胞肺癌生长激素抑制素受体显像的初步研究. 国际放射医学核医学杂志, 1994, 18(4): 192-192.
[10]	刘淼 , 刘兴党 . 生长抑素受体显像剂⁹⁹Tc^m-奥曲肽的SPECT研究. 国际放射医学核医学杂志, 2012, 36(3): 138-141. doi: 10.3760/cma.j.issn.1673-4114.2012.03.003

点击查看大图

计量

文章访问数: 1148
HTML全文浏览量: 144
PDF下载量: 2

瘦素和体重调节反馈模式的研究

雷呈志

作者简介:雷呈志(1973-),男,山西太原人,山西医科大学第一医院住院医师,影像与核医学专业硕士研究生,主要从事激素检测的临床应用研究。

300192 天津, 中国医学科学院放射医学研究所

收稿日期: 2002-01-27

关键词:

摘要: 瘦素(Leptin)被认为是一种外周组织反映脂肪量的信号,反馈作用于中枢神经系统。近年来,瘦素的负反馈系统已被部分揭示。下丘脑调节食欲和代谢的中枢受多种分子的协同作用,包括瘦素、神经肽Y(NPY),前阿片类黑色素原(POMC)等。根据已有的对瘦素的理解,建立一个关于瘦素负反馈的模型,可加深了解体内食欲和能量平衡调节机制。