多聚(ADP-核糖)聚合酶与电离辐射

杜翔; 龚守良

多聚(ADP-核糖)聚合酶与电离辐射

杜翔 , 龚守良

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 2: (116-119)

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多聚(ADP-核糖)聚合酶与电离辐射

杜翔,
龚守良

130021 长春, 吉林大学公共卫生学院卫生部放射生物学重点实验室
中图分类号: Q555;Q691.5

Poly (ADP-ribose) polymerase and ioni/ing radiation

Ministry of Health, Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China
CLC number: Q555;Q691.5

摘要: 多聚(ADP-核糖)聚合酶(PARP)是广泛存在于细胞内的一种具有蛋白修饰和核苷酸聚合作用的聚合酶,参与细胞DNA损伤后的修复过程。已经证实,PARP具有多种生理、生化功能,并与细胞的死亡相关,电离辐射等各种细胞损伤因素都可以影响PARP活性。
- 细胞凋亡 /
- 电离损伤 /
- 多聚(ADP-核糖)聚合酶
Abstract: Poly ADP-ribose ploymerase (PARP) is a kind of ploymerase which widely exists in cells, has the function of protein modification and nucleotide polymerazition, and participates in the repair processes after DNA has been damaged. It has been proved that PARP has lots of physiological and biochemistry functions and correlates with cell death. Many kinds of damage factors such as radiation may influence the activity of PARP.
- Apoptosis /
- Radiation injuries /
- Poly (ADP-ribose) polymerase
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