PET在前列腺癌中的应用

李亚军; 白人驹; 高硕

PET在前列腺癌中的应用

李亚军 , 白人驹 , 高硕

文章导航 > 国际放射医学核医学杂志 > 2006, 30 > 5: (283-286)

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PET在前列腺癌中的应用

300052 天津, 天津医科大学总医院PET-CT中心

通讯作者: 李亚军, liyj002@163.com ;

中图分类号: R817.4

The applying of PET imaging in prostate cancer

PET-CT Center, General Hospital of Tianjin Medical University, Tianjin 300052, China

Corresponding author: LI Ya-jun, liyj002@163.com ;

CLC number: R817.4

摘要: 前列腺癌是老年男性最常见的恶性肿瘤之一,PET在其早期诊断和准确分期方面具有重要价值。¹⁸F-氟代脱氧葡萄糖(¹⁸F-FDG)PET对前列腺癌的检出并不敏感,也不能可靠进行淋巴结分期,但¹⁸F-FDG摄取与疾病进展程度相关。¹¹C-胆碱PET诊断前列腺癌的准确率高,在淋巴结及骨转移的检出方面也明显优于¹⁸F-FDGPET,但其半衰期短而限制了临床应用。¹⁸F-胆碱的肿瘤摄取与¹¹C-胆碱相似,但在泌尿系统排泄较高。其他示踪剂如¹¹C-乙酸、¹¹C-甲硫氨酸、¹⁸F标记的雄激素等在前列腺癌的诊断、分期及疗效评价方面也具有一定价值。
- 前列腺肿瘤 /
- 体层摄影术,发射型计算机 /
- ¹⁸F-氟脱氧葡萄糖 /
- 胆碱
Abstract: Prostate cancer is one of the most common malignancies in old men, positron emission tomography is very valuable in early diagnosing and accurately staging of prostate cancer. ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG)PET is not sensitive in detection and reliable on staging of prostate cancer, but the uptake of ¹⁸F-FDG correlates with the stage of prostate cancer. ¹¹C-choline PET is accurate in diagnosis of prostate cancer, and it is superior to ¹⁸F-FDG PET in detection of metastases in lymph nodes and bone. But its short half-life limits the clinic applying in prostate cancer. The uptake of ¹⁸F-choline in prostate cancer is similar to ¹¹C-choline, but its excretion in urinary system is much higher than ¹¹C-choline. The other tracers such as ¹¹C-acetate, ¹¹C-methionine and 16β-¹⁸F-fluoro-5α-dihydrotestosterone are also valuable in diagnosing, staging and evaluating the effect of treatment of prostate cancer.
- Prostatic neoplasms /
- Tomography, emission-computed /
- ¹⁸F-fluorodeoxyglucose /
- Choline
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PET在前列腺癌中的应用

通讯作者: 李亚军, liyj002@163.com;

300052 天津, 天津医科大学总医院PET-CT中心

收稿日期: 2005-11-28

关键词:

摘要: 前列腺癌是老年男性最常见的恶性肿瘤之一,PET在其早期诊断和准确分期方面具有重要价值。¹⁸F-氟代脱氧葡萄糖(¹⁸F-FDG)PET对前列腺癌的检出并不敏感,也不能可靠进行淋巴结分期,但¹⁸F-FDG摄取与疾病进展程度相关。¹¹C-胆碱PET诊断前列腺癌的准确率高,在淋巴结及骨转移的检出方面也明显优于¹⁸F-FDGPET,但其半衰期短而限制了临床应用。¹⁸F-胆碱的肿瘤摄取与¹¹C-胆碱相似,但在泌尿系统排泄较高。其他示踪剂如¹¹C-乙酸、¹¹C-甲硫氨酸、¹⁸F标记的雄激素等在前列腺癌的诊断、分期及疗效评价方面也具有一定价值。