放射性核素标记RGD序列多肽与整合素α<sub>v</sub>β<sub>3</sub>受体显像的研究进展

刘晓飞; 张锦明; 王洁磊; 田嘉禾

放射性核素标记RGD序列多肽与整合素α_vβ₃受体显像的研究进展

刘晓飞 , 张锦明 , 王洁磊 , 田嘉禾

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 1: (12-15)

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放射性核素标记RGD序列多肽与整合素α_vβ₃受体显像的研究进展

1. 100853 北京, 解放军总医院核医学科;
2. 325000, 浙江温州武警浙江总队温州支队卫生队

通讯作者: 张锦明, zhangjm301@yahoo.com.cn ;

中图分类号: Q516

Study progress of malignant tumor imaging of integrin α_vβ₃ expression with radioisotope labelled RGD peptides

1. Department of Nuclear Medicine, The General Hospital of PLA, Beijing 100853, China;
2. Wenzhou Detachment Medical Team of Chinese People's Armed Police Forces, Zhejiang Wenzhou 325000, China

Corresponding author: ZHANG Jin-min, zhangjm301@yahoo.com.cn ;

CLC number: Q516

摘要: 整合素主要介导细胞与细胞、细胞与细胞外基质(ECM)之间的相互黏附,对细胞的黏附、增殖、分化、转移、凋亡起到重要的调控作用,在肿瘤的侵袭转移中发挥重要作用。成熟血管内皮细胞和绝大多数正常器官系统中,整合素α_vβ₃受体表达缺乏或几乎不能被探及,但其在新生血管内皮细胞中有强烈表达,精氨酸-甘氨酸-天冬氨酸(RGD)肽是整合素α_vβ₃受体的特异性识别位点,因此,将放射性核素标记到含有RGD序列的肽类化合物上,用于整合素α_vβ₃受体显像,对于肿瘤早期和高特异性定位、定量诊断及治疗都具有重要意义。近年来国内外对RGD肽的标记方法和α_vβ₃受体显像进行了研究。
- 肽类 /
- 受体,玻连蛋白 /
- 放射性核素显像 /
- 精氨酸-甘氨酸-天冬氨酸肽
Abstract: The malignant tumors must establish a neovasculature to grow, to invade, and to metastasize, in which α_vβ₃ integrin plays an important role. It is reported that the α_vβ₃ integrin made their effection mainly by binding triplet peptides RGD sequence in the proteins of the extracellular matrix. Because is reported to there is no or rare α_vβ₃ integrin in normal cells but more in activated endothelial cells, RGD is the special target point for α_vβ₃ Integrin. RGD antagonistic peptides radiolabelled by direct or indirect way could be used to display tumor α_vβ₃ Integrin by nuclear medicine image. It is of significance to locate and quantitate tumor Integrin high special in early diagnosis and therapy. This article reviews the marking method of RGD peptide and study about the image of α_vβ₃ receptor.
- Peptides /
- Receptors,vitronectin /
- Radionuclide imaging /
- Arginine-glyeine-aspartie acid
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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放射性核素标记RGD序列多肽与整合素α_vβ₃受体显像的研究进展

通讯作者: 张锦明, zhangjm301@yahoo.com.cn;

1. 100853 北京, 解放军总医院核医学科;
2. 325000, 浙江温州武警浙江总队温州支队卫生队

收稿日期: 2007-06-13

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摘要: 整合素主要介导细胞与细胞、细胞与细胞外基质(ECM)之间的相互黏附,对细胞的黏附、增殖、分化、转移、凋亡起到重要的调控作用,在肿瘤的侵袭转移中发挥重要作用。成熟血管内皮细胞和绝大多数正常器官系统中,整合素α_vβ₃受体表达缺乏或几乎不能被探及,但其在新生血管内皮细胞中有强烈表达,精氨酸-甘氨酸-天冬氨酸(RGD)肽是整合素α_vβ₃受体的特异性识别位点,因此,将放射性核素标记到含有RGD序列的肽类化合物上,用于整合素α_vβ₃受体显像,对于肿瘤早期和高特异性定位、定量诊断及治疗都具有重要意义。近年来国内外对RGD肽的标记方法和α_vβ₃受体显像进行了研究。

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放射性核素标记RGD序列多肽与整合素αvβ3受体显像的研究进展

通讯作者: 张锦明, zhangjm301@yahoo.com.cn ;

Study progress of malignant tumor imaging of integrin αvβ3 expression with radioisotope labelled RGD peptides

Corresponding author: ZHANG Jin-min, zhangjm301@yahoo.com.cn ;

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放射性核素标记RGD序列多肽与整合素αvβ3受体显像的研究进展

通讯作者: 张锦明, zhangjm301@yahoo.com.cn;

English Abstract

Study progress of malignant tumor imaging of integrin αvβ3 expression with radioisotope labelled RGD peptides

Corresponding author: ZHANG Jin-min, zhangjm301@yahoo.com.cn

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放射性核素标记RGD序列多肽与整合素α_vβ₃受体显像的研究进展

Study progress of malignant tumor imaging of integrin α_vβ₃ expression with radioisotope labelled RGD peptides

放射性核素标记RGD序列多肽与整合素α_vβ₃受体显像的研究进展

Study progress of malignant tumor imaging of integrin α_vβ₃ expression with radioisotope labelled RGD peptides