低剂量福射的细胞遗传适应性反应机理研究现状

吴国清

吴国清

文章导航 > 国际放射医学核医学杂志 > 2002, 26 > 3: (127-130)

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低剂量福射的细胞遗传适应性反应机理研究现状

吴国清

400016 重庆, 重庆医科大学核医学教研室

作者简介: 吴国清(1973-),男,浙江衢州人,硕士研究生,主要从事肿瘤放射治疗研究。;

中图分类号: R811.5

The intrinsic mechanism of cytogenetic adaptive response to low dose radiation

WU Guo-qing

Department of nuclear medicine, Chongqing University of Medical Science, Chongqing 400016, China
CLC number: R811.5

摘要: 很多学者对LDR(低剂量辐射)可以在体内及体外培养的细胞中诱导出适应性反应的机理进行了深入的研究,发现适应性反应的诱导与很多因素有关,这些因素包括LDR诱导的DNA修复系统的激活、LDR诱导的基因和蛋白的作用、抗氧化物酶的作用、细胞信号转导以及与P53蛋白有关的细胞周期阻滞的影响等。
- 低剂量辐射 /
- 适应性反应 /
- DNA修复 /
- 细胞周期
Abstract: Low dose radiation (LDR) can induce adaptive response in vivo and cultured cells.This phenomenon has been confirmed for more than 10 years. After the discovery, numerous research works on its intrinsic mechanism have been carried out. It was reported that the adaptive response is related to many factors. These factors include the DNA repair system induced by LDR,the function of genes and proteins induced by LDR,the function of antioxidant enzyme,cel-luar signal transduction and cell-cycle delay relation to p53 and so on.
- low dose radiation /
- adaptive response /
- DNA repair /
- cell cycle
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低剂量福射的细胞遗传适应性反应机理研究现状

吴国清

作者简介:吴国清(1973-),男,浙江衢州人,硕士研究生,主要从事肿瘤放射治疗研究。

400016 重庆, 重庆医科大学核医学教研室

收稿日期: 2002-01-30

关键词:

摘要: 很多学者对LDR(低剂量辐射)可以在体内及体外培养的细胞中诱导出适应性反应的机理进行了深入的研究,发现适应性反应的诱导与很多因素有关,这些因素包括LDR诱导的DNA修复系统的激活、LDR诱导的基因和蛋白的作用、抗氧化物酶的作用、细胞信号转导以及与P53蛋白有关的细胞周期阻滞的影响等。