放射治疗中肿瘤控制概率的影响因素
The influential factors of tumor control probability in radiotherapy
-
摘要: 可靠的肿瘤控制概率计算模型是对放射治疗方案进行准确评估的基础。所以,对肿瘤控制概率模型中所涉及的参数及对这些参数取值有影响的因素进行总结有利于提出更完善的计算模型。Abstract: The reliabie tumor control probability (TCP) model is fundamental to evaluate the effect of the protocol accurately in radiotherapy. In order to obtain the optimum TCP model, the parameters included in the model and the factors which can affect these parameters have been summarized.
-
Key words:
- tumor control probability /
- radiotherapy /
- clonogencell
-
[1] Skladowski K, Tarnawski R, Maciejewski B, et al. Clinical radiobiology of glottic T1 squamous cell carcinoma[J]. Int J Radiat Oncol Biol Phys, 1999, 43:101-109. [2] Buffa FM and Nahum AE. Monte Carlo dose calculations and radiobiological modelling:analysis of the effect of the statistical noise of the dose distribution on the probability of tumour control[J]. Phy Med Biol, 2000, 45: 3009-3023. [3] Willner J, Baier K, Pfreundner L, et al. Tumor volume and local control in primary radiotherapy of nasopharyngeal carcinoma[J]. Acta Oncolica, 1999, 38:1025-1030. [4] Buffa FM, Fenwick JD and Nahum AE. An analysis of relationship between radiosensitivity and volume effects in tumor control probability modeling[J]. Med Phys, 2000, 27:1258-1265. [5] Bentzen SM and Tucker SL. Quantifying the position and steepness of radiation dose-response curves[J]. Int J Radiat Biol, 1997, 71:531-542. [6] Britten RA, Evans AJ, Allalunis-Turner MJ, et al. Intratumoral heterogeneity as a confounding factor in clonogenic assays for tumour radioresponsiveness[J]. Racliother and Oncol, 1996, 39:145-153. [7] Laasonen A, Pyrhonen S, Kouri, et al. The effect of fractionated irradiation on cell kinetics[J]. Acta Oncologica, 1991, 30:51-56. [8] Urano M, Nishimura Y, Kuroda M, et al. Are hypoxic cells critical for the outcome of fractionated radiotherapy in a slow-growing mouse tumor[J]. Radiother and Oncol, 1998, 48:221-228. [9] Gatti RA. The inherited basis of human radiosensjtivity[J]. Acta Oncolgica, 2001, 40:702-711. [10] Eastham AM, Atkinson J and West CML. Relationships between clonogenic cell survival, DNA damage and chromosomal radiosensitivity in nine human cervix carcinoma cell lines[J]. Int J Radiat Biol, 2001, 77:295-302. [11] Sikpi MO and Wang Y. Ionizing radiation enhances doublestrand-break repair in rapamycin-treated ataxia telangiectasia lymphoblasts[J]. Int J Radiat Biol, 2000, 76:177-187. [12] Wilson GD. A new look at proliferation[J]. Acta Oncologica, 2001, 40:989-994. [13] Jones B and Dale RG. Mathematical models of tumour and normal tissue response[J]. Acta Oncologica, 1999, 38:883-893. [14] Budach W, Gioioso D, Taghian A, et al. Repopulation capacity during fractionated irradiation of squamous cell carcinomas and glioblastomas in vitro[J]. Int J Radiat Oncol Biol Phys, 1997, 39:743-750. [15] Fowler JF. Biological factors influencing optimum fractionat ion in radiation therapy[J]. Acta Oncologica, 2001, 40:712-717. [16] Baumann M, Petersen C, Schulz P, et al. Impact of overall treatment time on local control of slow growing human GL squamous cell carcinoma in nude mice treated by fractionat ed irradiation[J]. Radiother and Oncol, 1999, 50:107-111. [17] Baumann M, Hertz C, Baisch H, et al. Impact of overall treatment time of fractionated irradiation on local control of human FaDu squamous cell carcinoma in nude mice[J]. Radiother and Oncol, 1994, 32:137-143. [18] Petersen C, Zips D, Krause M, et al. Repopulation of FaDu human squamous carcinoma during fractionated radiotherapy correlates with reoxygenation[J]. Int J Radiat Oncol Biol Phys, 2001, 51:483-493. [19] Roberts SA and Hendry JH. The delay before onset of accelerated tumour cell repopulation during radiotherapy:a direct maximum-likelihood analysis of a collection of worldwide tumour-control data[J]. Radiother and Oncol, 1993, 29:69-74. [20] Thames HD, Ruifrok ACC, Milas L, et al. Accelerated repopulationduring fractionated irradiation of a murine ovarian carcinoma:downregulation of apoptosis as a possible mechanism[J]. Int J Radiat Oncol Biol Phys, 1996, 35:951-962. [21] Beck-Bornholdt HP, Omniczynski M, Theis E, et al. Influence of treatment time on the response of rat rhabdomyosarcoma R1H to fractionated irradiation[J]. Acta Oncologica, 1991, 30:57-63. [22] Roberts SA and Hendry JH. Time factors in larynx tumor radiotherapy:lag times and intertumor heterogeneity in clinical datasets from four centers[J]. Int J Radiat Oncol Biol Phys, 1999, 45:1247-1257. [23] Sanchez-Nieto B, Nahum AE and Dearnaley DP. Individualization of dose prescription based on normal-tissue dosevolume and radiosensitivity data[J]. Int J Radiat Oncol Biol Phys, 2001, 49:487-499.
点击查看大图
计量
- 文章访问数: 1366
- HTML全文浏览量: 89
- PDF下载量: 3