PET-CT在卵巢癌中的临床应用价值

董孟杰 林祥通 赵军

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PET-CT在卵巢癌中的临床应用价值

  • 中图分类号: R814.42;R817.4

The application of PET-CT in ovarian cancer

  • CLC number: R814.42;R817.4

  • 摘要: 卵巢癌是妇科较常见的恶性肿瘤及致死原因,正电子发射体层显像(PET)对于卵巢癌的诊断、分期、复发及疗效监测及预后方面优于常规的检测手段(CT、MRI及肿瘤标志物检查);PET-CT对指导手术有重要价值;特异性PET显像剂的研制已取得初步成果,124I-C6.5 diabody已经成功用于动物的PET-CT。
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    [2] Torizuka T, Kanno T, Futatsubashi M, et al. Imaging of gynecologic tumors:comparison of (11)C-choline PET with (18)F-FDG PET[J].J Nucl Med,2003, 44(7):1051-1056.
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    [4] Nishizawa S, Inubushi M, Okada H. Physiological 18F-FDG uptake in the ovaries and uterus of healthy female volunteers[J]. Eur J Nucl Med Mol Imaging, 2005, 32(5):549-556.
    [5] Torizuka T, Nobezawa S, Kanno T, et al. Ovarian cancer recurrence:role of whole-body positron emission tomography using2-[fluorine-18]-fluoro-2-deoxy-D-glucose[J]. Eur J Nucl Med Mol Imaging, 2002, 29(6):797-803.
    [6] Nakamoto Y, Saga T, Ishimori I, et al. Clinical value of positron emission tomography with FDG for recurrent ovarian cancer[J]. Am J Roentgenol, 2001, 176(6):1449-1454.
    [7] Menzel C, Dobert N, Hamscho N, et al. The influence of CA 125and CEA levels on the results of (18)F-deoxyglucose positron emission tomography in suspected recurrence of epithelial ovarian cancer[J]. Strahlenther Onkol, 2004, 180(8):497-501.
    [8] Havrilesky LJ, Kulasingam SL, Matchar DB, et al. FDG-PET for management of cervical and ovarian cancer[J]. Gynecol Oncol,2005, 97(1):183-191.
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    [13] Bristow RE, delCarmen MG, Pannu HK, et al. Clinically occult recurrent ovarian cancer:patient selection for secondary cytoreduc-tive surgery usingcombinedPET/CT[J]. GynecolOncol, 2003, 90(3):519-528.
    [14] Casey MJ, Gupta NC, Muths CK. Experience with positron emission tomography (PET) scans in patients with ovarian cancer[J]. Gynecol Oncol, 1994, 53(5):331-338.
    [15] Rose PG, Faulhaber P, Miraldi F, et al. Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma:correlation with second-look laparotomy[J]. Gynecol Oncol, 2001, 82(1):17-21.
    [16] Zimny M, Siggelkow W, Schroder W, et al. 2-[Fluorine-18]-fluoro2-deoxy-d-glucose positron emission tomography in the diagnosis of recurrent ovarian cancer[J]. Gynecol Oncol, 2001, 83(2):310-315.
    [17] Miller TR, Grigsby PW. Measurement oftumor volume by PET to evaluate prognosis in patients with advanced cervical cancer treat-ed by radiation therapy[J]. Int J Radiat Oncol Biol Phys, 2002, 53(2):353-359.
    [18] Barranger E, Kerrou K, Petegnief Y. Laparoscopic resection of occult metastasis using the combination of FDG-positron emission tomography/computed tomography image fusion with intraoperative probe guidance in a woman with recurrent ovarian cancer[J]. Gynecol Oncol, 2005, 96(1):241-244.
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  • 收稿日期:  2005-07-08

PET-CT在卵巢癌中的临床应用价值

  • 200040 上海, 复旦大学附属华山医院核医学科

摘要: 卵巢癌是妇科较常见的恶性肿瘤及致死原因,正电子发射体层显像(PET)对于卵巢癌的诊断、分期、复发及疗效监测及预后方面优于常规的检测手段(CT、MRI及肿瘤标志物检查);PET-CT对指导手术有重要价值;特异性PET显像剂的研制已取得初步成果,124I-C6.5 diabody已经成功用于动物的PET-CT。

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