VEGF与肿瘤的放射治疗

刘英; 陈龙华; 巩湘浩; 吕国士

VEGF与肿瘤的放射治疗

刘英 , 陈龙华 , 巩湘浩 , 吕国士

文章导航 > 国际放射医学核医学杂志 > 2003, 27 > 4: (183-186)

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VEGF与肿瘤的放射治疗

1. 510515 广州, 第一军医大学南方医院放射肿瘤科;
2. 421001 衡阳, 湖南省衡阳市中心医院湖南;
3. 510515 广州, 第一军医大学南方医院影像中心

作者简介: 刘英(1974-),女,硕士研究生,主要从事肿瘤影像诊断与放射治疗的实验和临床研究;陈龙华(1952-),男,主任,教授,博士生导师,主要从事肿瘤影像诊断与放射治疗的基础和临床研究;巩湘浩(1972-),男,主治医生,主要从事肿瘤内科与放射治疗临床工作;吕国士(1972-),男,硕士研究生,主要从事CT、MRI影像诊断实验及临床研究工作。;

中图分类号: R817.5

VEGF and radiation sensibitity

Nanfang Hospital, First Militouy Medical University, Guangzhou 510515, China
CLC number: R817.5

摘要: 肿瘤的VEGF(血管内皮生长因子)表达与肿瘤的生长、侵袭、远处转移密切相关,它反映了接受放射治疗肿瘤的生物学和临床行为。回顾近年来的文献说明:(1)各种不同的肿瘤组织在放疗后均表现为VEGF水平上调。(2)肿瘤的高VEGF表达,提示该肿瘤对放射治疗不敏感,预示着疗效不佳。因此,通过拮抗VEGF表达,可以增强放疗疗效。测定VEGF含量可以评估肿瘤的新生血管生成,并据此对肿瘤进行分类,用于制定个性化放疗方案。
- 血管内皮生长因子 /
- 恶性肿瘤 /
- 放射治疗
Abstract: VEGF (vascular endothelial growth factor)is important for tumor growth,local invasion and the distant metastasis.It provides important information about the biology and the clinical behavior of tumors undergoing radiotherapy.This review summarizing the present study reports and suggests: (1)Irradiation can induce VEGF expression in diverse tumor cell types. (2)VEGF can be as a predictive factor of response to radiotherapy.VEGF increases in tumors will be resistant to radiation therapy.Anti-VEGF strategies can be used in combination with radiation therapy,and it can increase the anti-tumor effects of radiation therapy.A classification of tumors according to their VEGF level before therapy can be used into designed individual treatment planning.
- vascular endothe lial growth factor /
- malignant tumors /
- radiation therapy
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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VEGF与肿瘤的放射治疗

作者简介:刘英(1974-),女,硕士研究生,主要从事肿瘤影像诊断与放射治疗的实验和临床研究;陈龙华(1952-),男,主任,教授,博士生导师,主要从事肿瘤影像诊断与放射治疗的基础和临床研究;巩湘浩(1972-),男,主治医生,主要从事肿瘤内科与放射治疗临床工作;吕国士(1972-),男,硕士研究生,主要从事CT、MRI影像诊断实验及临床研究工作。

1. 510515 广州, 第一军医大学南方医院放射肿瘤科;
2. 421001 衡阳, 湖南省衡阳市中心医院湖南;
3. 510515 广州, 第一军医大学南方医院影像中心

收稿日期: 2003-03-31

关键词:

摘要: 肿瘤的VEGF(血管内皮生长因子)表达与肿瘤的生长、侵袭、远处转移密切相关,它反映了接受放射治疗肿瘤的生物学和临床行为。回顾近年来的文献说明:(1)各种不同的肿瘤组织在放疗后均表现为VEGF水平上调。(2)肿瘤的高VEGF表达,提示该肿瘤对放射治疗不敏感,预示着疗效不佳。因此,通过拮抗VEGF表达,可以增强放疗疗效。测定VEGF含量可以评估肿瘤的新生血管生成,并据此对肿瘤进行分类,用于制定个性化放疗方案。